Peptide record

TPDB05048

Vasoactive intestina Vasoactive intestinal peptide Antibacterial Anticancer Antifungal Antiparasitic Antiviral Blood-Brain Barrier Cell-penetrating Peptides Neuropeptide Toxicity standard

28 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB05048

Peptide_Name

Vasoactive intestina Vasoactive intestinal peptide

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Blood-Brain Barrier Cell-penetrating Peptides Neuropeptide Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides Neuroactive peptides

Database_Source

AntiBP3 dbAMP Peptipedia AFP-GFuse Antifungipept CAFPdb i2APP AI4AVP B3Pred BBPpredict CPPsite3.0 ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 28-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.

Sequence

HSDAVFTDNYTRLRKQMAVKKYLNSILN

FASTA

>TPDB05048|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral;Blood-Brain Barrier;Cell-penetrating Peptides;Neuropeptide;Toxicity|length=28
HSDAVFTDNYTRLRKQMAVKKYLNSILN

Formula C147H237N43O43S1

Absent Amino Acids CEGPW

Common Amino Acids NLK

Mass 3326.82

PI 10.22

Basic Residues 6

Acidic Residues 2

Hydrophobic Residues 12

Net Charge +3

Boman Index 4.96

Hydrophobicity -0.639

Aliphatic Index 83.57

Half Life

Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour

Extinction Coefficient Cystines 2980

Absorbance 280nm 89.57

Polar Residues 10

number

Amino Acid Distribution

A: 2 R: 2 N: 3 D: 2 C: 0 E: 0 Q: 1 G: 0 H: 1 I: 1 L: 3 K: 3 M: 1 F: 1 P: 0 S: 2 T: 2 W: 0 Y: 2 V: 2

Length

Formula

C147H237N43O43S1

Mass

3326.82

10.22

Net Charge

Boman Index

4.96

Hydrophobicity

-0.639

Conformation

Linear

Peptide_Length

Similarity

Peptide_Sequence_3Letter

His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn

SMILES

CCC(C)C(NC(=O)C(CO)NC(=O)C(CC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(CC1=CC=C(O)C=C1)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(NC(=O)C(C)NC(=O)C(CCSC)NC(=O)C(CCC(N)=O)NC(=O)C(CCCCN)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(N)=N)NC(=O)C(NC(=O)C(CC1=CC=C(O)C=C1)NC(=O)C(CC(N)=O)NC(=O)C(CC(O)=O)NC(=O)C(NC(=O)C(CC1=CC=CC=C1)NC(=O)C(NC(=O)C(C)NC(=O)C(CC(O)=O)NC(=O)C(CO)NC(=O)C(N)CC1=CN=CN1)C(C)C)C(C)O)C(C)O)C(C)C)C(=O)NC(CC(C)C)C(=O)NC(CC(N)=O)C(N)=O

Evidence 1 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.0004 mL/(g x min)

Assay & Model

Animal Model Origin/Source

Response Unidirectional influx rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin human,bovine,mouse,rat,porcine

In Vivo Mode of Delivery Intravenous

Transport Type non saturable

Label Direct iodination

Evidence 2 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.00028 ml/g

Assay & Model

Animal Model Origin/Source

Response Initial distribution volume

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin human,bovine,mouse,rat,porcine

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

Evidence 3 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.00216 mL/(g x min)

Assay & Model

Animal Model Origin/Source

Response Unidirectional flux rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin human,bovine,mouse,rat,porcine

In Vivo Mode of Delivery in situ brain perfusion

Transport Type non saturable

Label Direct iodination

Evidence 4 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 86.6 %/g

Assay & Model

In Vitro Method HPLC

Animal Model Origin/Source

Response % injected dose

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin human,bovine,mouse,rat,porcine

Label Direct iodination

Evidence 5 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 69.8 %/g

Assay & Model

In Vitro Method HPLC

Animal Model Origin/Source

Response % injected dose

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin human,bovine,mouse,rat,porcine

Label Direct iodination

Evidence 6 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 72.2 %/g

Assay & Model

In Vitro Method HPLC

Animal Model Origin/Source

Response % injected dose

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin human,bovine,mouse,rat,porcine

Label Direct iodination

Evidence 7 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result -2.19

Assay & Model

In Vitro Method Shake Flask

Animal Model Origin/Source

Response Log P

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin human,bovine,mouse,rat,porcine

Label Direct iodination

Evidence 8 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Pituitary adenylate cyclase-activating polypeptide type I receptor

Receptor Organisms Bos taurus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Bos taurus

Family Glucagon

Receptor Lengths 513

Receptor Ligands NP04401 NP04415 NP04424 NP04450 NP04376 NP04463

Evidence 9 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Canis lupus familiaris

Family Glucagon

Evidence 10 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Capra hircus

Family Glucagon

Evidence 11 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal polypeptide receptor 2

Receptor Organisms Homo sapiens Homo sapiens

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Homo sapiens

Family Glucagon

Receptor Lengths 457 438

Receptor Ligands NP04418 NP04427 NP04470 NP04418 NP04427 NP04470

Evidence 12 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Macaca mulatta

Family Glucagon

Evidence 13 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal polypeptide receptor 2

Receptor Organisms Mus musculus Mus musculus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Mus musculus

Family Glucagon

Receptor Lengths 459 437

Receptor Ligands NP04473 NP04419 NP04428 NP04473

Evidence 14 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Vasoactive intestinal polypeptide receptor 1

Receptor Organisms Sus scrofa

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Sus scrofa

Family Glucagon

Receptor Lengths 458

Receptor Ligands NP04476

Evidence 15 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Oryctolagus cuniculus

Family Glucagon

Evidence 16 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal polypeptide receptor 2

Receptor Organisms Rattus norvegicus Rattus norvegicus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Rattus norvegicus

Family Glucagon

Receptor Lengths 459 437

Receptor Ligands NP04478 NP04422 NP04431 NP04478

Evidence 17 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Ovis aries

Family Glucagon

Evidence 18 Activity

Activity

Activity Endpoint 10% Cell death

Detail Source Activity Toxicity

Activity Measurement 100 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

10% Cell death | 100 | µg/mL | target cell: Human pulp fibroblasts

Target

Target Cell Human pulp fibroblasts

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Antimicrobial activity of neuropeptides against a range of micro-organisms from skin, oral, respiratory and gastrointestinal tract sites. | J Neuroimmunol | 2008

Family

Glucagon

In_Vivo_Mode_of_Delivery

Intravenous in situ brain perfusion

Receptor_Lengths

513 457 438 459 437 458

Receptor_Ligands

NP04401 NP04415 NP04424 NP04450 NP04376 NP04463 NP04418 NP04427 NP04470 NP04473 NP04419 NP04428 NP04476 NP04478 NP04422 NP04431