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Peptide record

TPDB05039

Antibacterial Anticancer Antidiabetic Antifungal Antiparasitic Hemolysis Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB05039
Antibacterial Anticancer Antidiabetic Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cardiometabolic peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP pep-lab Peptipedia Antifungipept CAFPdb APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 24-aa standard natural multi-activity (Antibacterial, Anticancer, Antidiabetic, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLPLLAGLAANFLPKIFCKITRKC
Physicochemical Analysis
C128H209N31O27S2
DEQHMSWYV
L
2678.38
10.32
4
0
13
+4
-2.55
0.950
126.25
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
125
4.67
4
Residue Composition
number
3
A
1
R
1
N
0
D
2
C
0
E
0
Q
1
G
0
H
2
I
5
L
3
K
0
M
3
F
2
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 1 N: 1 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 5 K: 3 M: 0 F: 3 P: 2 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
24
C128H209N31O27S2
2678.38
10.32
+4
-2.55
0.950
Evidence Records 10 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
inhibition zone assay (lethal concentration LC: minimal concnetration for inhibition, MIC-like): Active against E. coli D21 (LC 1.8 uM), B. megaterium BmII, S. aureus Cowan 1 (LC 0.4-0.6 uM), P. aeruginosa ATCC15692 (LC 30.6 uM), C. albicans, and S. cerevisiae (LC 3.8-4.7 uM). In addition, this peptide promotes insulin secretion in acute 20-min incubations with glucose responsive BRIN-BD11 cells ( Marenah L et al., 2006 ), thereby of interest for type 2 diabetes (T2D).
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
inhibition zone assay (lethal concentration LC: minimal concnetration for inhibition, MIC-like): Active against E. coli D21 (LC 1.8 uM), B. megaterium BmII, S. aureus Cowan 1 (LC 0.4-0.6 uM), P. aeruginosa ATCC15692 (LC 30.6 uM), C. albicans, and S. cerevisiae (LC 3.8-4.7 uM). In addition, this peptide promotes insulin secretion in acute 20-min incubations with glucose responsive BRIN-BD11 cells ( Marenah L et al., 2006 ), thereby of interest for type 2 diabetes (T2D).
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

DRAMP

Other

inhibition zone assay (lethal concentration LC: minimal concnetration for inhibition, MIC-like): Active against E. coli D21 (LC 1.8 uM), B. megaterium BmII, S. aureus Cowan 1 (LC 0.4-0.6 uM), P. aeruginosa ATCC15692 (LC 30.6 uM), C. albicans, and S. cerevisiae (LC 3.8-4.7 uM). In addition, this peptide promotes insulin secretion in acute 20-min incubations with glucose responsive BRIN-BD11 cells ( Marenah L et al., 2006 ), thereby of interest for type 2 diabetes (T2D).
Evidence 4 Activity

Activity

LC50
Hemolysis
0.5 µM
[Ref.8163497] LC50=0.5 µM against human red blood cell.

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
FEBS Lett. 1993 Jun 14 324(2):159-161.##J Biol Chem. 1994 Apr 22 269(16):11956-11961.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 5 Activity

Activity

100% Hemolysis
Toxicity
0.5 µM
Hemolytic Cytotoxic
100% Hemolysis | 0.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Novel antimicrobial peptides from skin secretion of the European frog Rana esculenta | FEBS Lett | 1993
Evidence 6 Activity

Activity

100% Hemolysis
Toxicity
0.7 µM
Hemolytic Cytotoxic
100% Hemolysis | 0.7 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Structure-function studies on the amphibian peptide brevinin 1E: translocating the cationic segment from the C-terminal end to a central position favors selective antibacterial activity. | J Pept Res | 2001
Evidence 7 Activity

Activity

50% Hemolysis
Toxicity
1.1 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 1.1 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Structure-activity analysis of brevinin 1E amide, an antimicrobial peptide from Rana esculenta. | Biochim Biophys Acta | 1998
Evidence 8 Activity

Activity

50% Hemolysis
Toxicity
1.6 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 1.6 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Structure-activity analysis of brevinin 1E amide, an antimicrobial peptide from Rana esculenta. | Biochim Biophys Acta | 1998
Evidence 9 Activity

Activity

LC50
Toxicity
0.5 µM
Hemolytic
Hemolytic_activity: [Ref.8163497] LC50=0.5 µM against human red blood cell.

Target

erythrocytes

Source & Reference

NA
DRAMP
FEBS Lett. 1993 Jun 14 324(2):159-161.##J Biol Chem. 1994 Apr 22 269(16):11956-11961.
Evidence 10 Hemolysis

Activity

0.5 µM
LC50
[Ref.8163497] LC50=0.5 µM against human red blood cell.
Hemolysis

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
FEBS Lett. 1993 Jun 14 324(2):159-161.##J Biol Chem. 1994 Apr 22 269(16):11956-11961.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.