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Peptide record

TPDB05034

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB05034
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia AntiCP 2.0 dbACP iACP-DRLF pep-lab Antifungipept APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 30-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AntiCP 2.0, and other sources, with an available 3D structural model.
Sequence
GLPVCGETCFGGTCNTPGCSCETWPVCSRN
Physicochemical Analysis
C125H192N36O43S6
ADQHIKMY
C
3079.47
4.26
1
2
5
-1
3.07
-0.020
32.33
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5875
190.78
14
Residue Composition
number
0
A
1
R
2
N
0
D
6
C
2
E
0
Q
5
G
0
H
0
I
1
L
0
K
0
M
1
F
3
P
2
S
4
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 1 N: 2 D: 0 C: 6 E: 2 Q: 0 G: 5 H: 0 I: 0 L: 1 K: 0 M: 0 F: 1 P: 3 S: 2 T: 4 W: 1 Y: 0 V: 2
Chemical Descriptors
30
C125H192N36O43S6
3079.47
4.26
-1
3.07
-0.020
Evidence Records 4 records
Evidence 1 Activity

Activity

HD50
Hemolysis
7.52 µM
[Ref.20580652] HD50=7.52µM against human type O red blood cells.

Target

human type O red blood cells

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
J Nat Prod. 1999 Feb 62(2):283-286.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
7.52 µM
Hemolytic Cytotoxic
50% Hemolysis | 7.52 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Isolation and characterization of cytotoxic cyclotides from Viola tricolor. | Peptides | 2010
Evidence 3 Activity

Activity

HD50
Toxicity
7.52 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.20580652] HD50=7.52µM against human type O red blood cells. | Cytotoxicity: [Ref.20580652] Cytotoxicity: U251(IC50=44.70µg/mL), MDA-MB-231(IC50>10µg/mL), A549(IC50>10µg/mL), DU145(IC50>10µg/mL), BEL-7402(IC50>10µg/mL).

Target

erythrocytes

Source & Reference

NA
DRAMP
J Nat Prod. 1999 Feb 62(2):283-286.
Evidence 4 Hemolysis

Activity

7.52 µM
HD50
[Ref.20580652] HD50=7.52µM against human type O red blood cells.
Hemolysis

Target

human type O red blood cells

Source & Reference

APD_complete HemoPI PD_Hemolysis
J Nat Prod. 1999 Feb 62(2):283-286.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.