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Peptide record

TPDB05030

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Cell-penetrating Peptides Hemolysis Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB05030
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Cell-penetrating Peptides Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb AI4AVP dbAMP 3.0 DRAVP 2.0 CPPsite3.0 APD_complete HemoPI PD_Hemolysis ToxinPred 3.0
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GMASKAGAIAGKIAKVALKAL
Physicochemical Analysis
C88H161N25O23S1
RNDCEQHFPTWY
A
1969.46
11.00
4
0
13
+4
1.03
0.843
121.43
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
7
A
0
R
0
N
0
D
0
C
0
E
0
Q
3
G
0
H
2
I
2
L
4
K
1
M
0
F
0
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 7 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 2 L: 2 K: 4 M: 1 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
21
C88H161N25O23S1
1969.46
11.00
+4
1.03
0.843
Evidence Records 133 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6-25 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Activity was demonstrated in 1988 (see ref). Active against E. coli ATCC 25922 (MIC 6-25 uM), P.aeruginosa ATCC 27883 (MIC 200-500 ug/ml), S. aureus ATCC 25923 or MRSA (MIC 25-50 uM)
Evidence 2 Activity

Activity

MIC
Antibacterial
200-500 µg/mL

Target

P.aeruginosa ATCC 27883

Source & Reference

dbAMP DRAMP

Other

vity was demonstrated in 1988 (see ref). Active against E. coli ATCC 25922 (MIC 6-25 uM), P.aeruginosa ATCC 27883 (MIC 200-500 ug/ml), S. aureus ATCC 25923 or MRSA (MIC 25-50 uM)c, S. pyogenes ATCC 19615 (MIC 10-50 ug/ml),
Evidence 3 Activity

Activity

MIC
Antibacterial
25-50 µM

Target

Staphylococcus aureus ATCC 25923 or MRSA

Source & Reference

dbAMP DRAMP

Other

ve against E. coli ATCC 25922 (MIC 6-25 uM), P.aeruginosa ATCC 27883 (MIC 200-500 ug/ml), S. aureus ATCC 25923 or MRSA (MIC 25-50 uM)c, S. pyogenes ATCC 19615 (MIC 10-50 ug/ml), S. cerevisiae ATCC A3180, and C.albicans (MIC
Evidence 4 Activity

Activity

MIC
Antibacterial
10-50 µg/mL

Target

Streptococcus pyogenes ATCC 19615

Source & Reference

dbAMP DRAMP

Other

.aeruginosa ATCC 27883 (MIC 200-500 ug/ml), S. aureus ATCC 25923 or MRSA (MIC 25-50 uM)c, S. pyogenes ATCC 19615 (MIC 10-50 ug/ml), S. cerevisiae ATCC A3180, and C.albicans (MIC 100-200 ug/ml). protozoan P. caudatum (min
Evidence 5 Activity

Activity

MIC
Antibacterial
100-200 µg/mL

Target

C.albicans

Source & Reference

dbAMP DRAMP

Other

(MIC 25-50 uM)c, S. pyogenes ATCC 19615 (MIC 10-50 ug/ml), S. cerevisiae ATCC A3180, and C.albicans (MIC 100-200 ug/ml). protozoan P. caudatum (minimal disruptive conc MDC 5 ug/ml), A. castellani (MDC 2 ug/ml)
Evidence 6 Activity

Activity

MIC
Antibacterial
0.6-1.2 µM

Target

A. viridans

Source & Reference

dbAMP DRAMP

Other

/ml), A. castellani (MDC 2 ug/ml), and T. pyriformis (MDC 20 ug/ml). Active against Gram+ A. viridans (MIC 0.6-1.2 uM), M. luteus (MIC 0.3-0.6 uM), B. megaterium (MIC 1.3-2.6 uM), B. subtilis (MIC 0.6-1.3 uM)
Evidence 7 Activity

Activity

MIC
Antibacterial
0.3-0.6 µM

Target

M. luteus

Source & Reference

dbAMP DRAMP

Other

ml), and T. pyriformis (MDC 20 ug/ml). Active against Gram+ A. viridans (MIC 0.6-1.2 uM), M. luteus (MIC 0.3-0.6 uM), B. megaterium (MIC 1.3-2.6 uM), B. subtilis (MIC 0.6-1.3 uM), S. aureus (MIC 1.3-2.6 uM)
Evidence 8 Activity

Activity

MIC
Antibacterial
1.3-2.6 µM

Target

B. megaterium

Source & Reference

dbAMP DRAMP

Other

20 ug/ml). Active against Gram+ A. viridans (MIC 0.6-1.2 uM), M. luteus (MIC 0.3-0.6 uM), B. megaterium (MIC 1.3-2.6 uM), B. subtilis (MIC 0.6-1.3 uM), S. aureus (MIC 1.3-2.6 uM), P. acidolactici (MIC 1.3-2.6 u
Evidence 9 Activity

Activity

MIC
Antibacterial
0.6-1.3 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

A. viridans (MIC 0.6-1.2 uM), M. luteus (MIC 0.3-0.6 uM), B. megaterium (MIC 1.3-2.6 uM), B. subtilis (MIC 0.6-1.3 uM), S. aureus (MIC 1.3-2.6 uM), P. acidolactici (MIC 1.3-2.6 uM), Gram- E. coli (MIC 1.3-2.6
Evidence 10 Activity

Activity

MIC
Antibacterial
1.3-2.6 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

M. luteus (MIC 0.3-0.6 uM), B. megaterium (MIC 1.3-2.6 uM), B. subtilis (MIC 0.6-1.3 uM), S. aureus (MIC 1.3-2.6 uM), P. acidolactici (MIC 1.3-2.6 uM), Gram- E. coli (MIC 1.3-2.6 uM), S. typhimuriumn (MIC 5
Evidence 11 Activity

Activity

MIC
Antibacterial
1.3-2.6 µM

Target

P. acidolactici

Source & Reference

dbAMP DRAMP

Other

B. megaterium (MIC 1.3-2.6 uM), B. subtilis (MIC 0.6-1.3 uM), S. aureus (MIC 1.3-2.6 uM), P. acidolactici (MIC 1.3-2.6 uM), Gram- E. coli (MIC 1.3-2.6 uM), S. typhimuriumn (MIC 5.2-52 uM), K pneumoniae (MIC 1.3-2
Evidence 12 Activity

Activity

MIC
Antibacterial
1.3-2.6 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

lis (MIC 0.6-1.3 uM), S. aureus (MIC 1.3-2.6 uM), P. acidolactici (MIC 1.3-2.6 uM), Gram- E. coli (MIC 1.3-2.6 uM), S. typhimuriumn (MIC 5.2-52 uM), K pneumoniae (MIC 1.3-2.6 uM), E. cloacae (MIC 1.3-2.6
Evidence 13 Activity

Activity

MIC
Antibacterial
5.2-52 µM

Target

S. typhimuriumn

Source & Reference

dbAMP DRAMP

Other

ureus (MIC 1.3-2.6 uM), P. acidolactici (MIC 1.3-2.6 uM), Gram- E. coli (MIC 1.3-2.6 uM), S. typhimuriumn (MIC 5.2-52 uM), K pneumoniae (MIC 1.3-2.6 uM), E. cloacae (MIC 1.3-2.6 uM), E. carotovora (MIC 1.3-2.6 u
Evidence 14 Activity

Activity

MIC
Antibacterial
1.3-2.6 µM

Target

Enterobacter cloacae

Source & Reference

dbAMP DRAMP

Other

E. coli (MIC 1.3-2.6 uM), S. typhimuriumn (MIC 5.2-52 uM), K pneumoniae (MIC 1.3-2.6 uM), E. cloacae (MIC 1.3-2.6 uM), E. carotovora (MIC 1.3-2.6 uM), P. aeruginosa (MIC 5.2-52 uM) (see ref for Thanatin). Ac
Evidence 15 Activity

Activity

MIC
Antibacterial
1.3-2.6 µM

Target

E. carotovora

Source & Reference

dbAMP DRAMP

Other

typhimuriumn (MIC 5.2-52 uM), K pneumoniae (MIC 1.3-2.6 uM), E. cloacae (MIC 1.3-2.6 uM), E. carotovora (MIC 1.3-2.6 uM), P. aeruginosa (MIC 5.2-52 uM) (see ref for Thanatin). Active against B. dendrobatidis (T
Evidence 16 Activity

Activity

MIC
Antibacterial
5.2-52 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

pneumoniae (MIC 1.3-2.6 uM), E. cloacae (MIC 1.3-2.6 uM), E. carotovora (MIC 1.3-2.6 uM), P. aeruginosa (MIC 5.2-52 uM) (see ref for Thanatin). Active against B. dendrobatidis (Table 1, Rollins-Smith, BBA 2009
Evidence 17 Activity

Activity

MIC
Antibacterial
2.3-4.6 µM

Target

B. cereus

Source & Reference

dbAMP DRAMP

Other

ndrobatidis (Table 1, Rollins-Smith, BBA 2009 1788:1593-1599). ALso active against Gram+ B. cereus (MIC 2.3-4.6 uM), B. thuringiensis (MIC 4.6-46 uM), C. michiganensis (MIC 1.15-2.3 uM), Gram- P. cepacia,
Evidence 18 Activity

Activity

MIC
Antibacterial
4.6-46 µM

Target

B. thuringiensis

Source & Reference

dbAMP DRAMP

Other

s-Smith, BBA 2009 1788:1593-1599). ALso active against Gram+ B. cereus (MIC 2.3-4.6 uM), B. thuringiensis (MIC 4.6-46 uM), C. michiganensis (MIC 1.15-2.3 uM), Gram- P. cepacia, P. syringae, P. syringae pv. syrin
Evidence 19 Activity

Activity

MIC
Antibacterial
1.15-2.3 µM

Target

C. michiganensis

Source & Reference

dbAMP DRAMP

Other

. ALso active against Gram+ B. cereus (MIC 2.3-4.6 uM), B. thuringiensis (MIC 4.6-46 uM), C. michiganensis (MIC 1.15-2.3 uM), Gram- P. cepacia, P. syringae, P. syringae pv. syringae, P. syringae phaseoli (MIC 1.15-
Evidence 20 Activity

Activity

MIC
Antibacterial
1.15-2.3 µM

Target

P. syringae phaseoli

Source & Reference

dbAMP DRAMP

Other

michiganensis (MIC 1.15-2.3 uM), Gram- P. cepacia, P. syringae, P. syringae pv. syringae, P. syringae phaseoli (MIC 1.15-2.3 uM), P. pisi (MIC 0.6-1.15 uM), P-maculicola, P-valerianella (MIC >30 uM), X. campestris pv.
Evidence 21 Activity

Activity

MIC
Antibacterial
0.6-1.15 µM

Target

P. pisi

Source & Reference

dbAMP DRAMP

Other

. cepacia, P. syringae, P. syringae pv. syringae, P. syringae phaseoli (MIC 1.15-2.3 uM), P. pisi (MIC 0.6-1.15 uM), P-maculicola, P-valerianella (MIC >30 uM), X. campestris pv. oryzae (MIC 4.6-46 uM), X.
Evidence 22 Activity

Activity

MIC
Antibacterial
4.6-46 µM

Target

v. oryzae

Source & Reference

dbAMP DRAMP

Other

uM), P. pisi (MIC 0.6-1.15 uM), P-maculicola, P-valerianella (MIC >30 uM), X. campestris pv. oryzae (MIC 4.6-46 uM), X. campestris pv. campestris (MIC 0.3-0.6 uM), X. vesicatoria 687.3, and X. vesicatoria
Evidence 23 Activity

Activity

MIC
Antibacterial
0.3-0.6 µM

Target

v. campestris

Source & Reference

dbAMP DRAMP

Other

la, P-valerianella (MIC >30 uM), X. campestris pv. oryzae (MIC 4.6-46 uM), X. campestris pv. campestris (MIC 0.3-0.6 uM), X. vesicatoria 687.3, and X. vesicatoria B229RI (MIC 0.6-1.15 uM) ( Ehret-Sabatier et al
Evidence 24 Activity

Activity

MIC
Antibacterial
0.6-1.15 µM

Target

X. vesicatoria B229RI

Source & Reference

dbAMP DRAMP

Other

(MIC 4.6-46 uM), X. campestris pv. campestris (MIC 0.3-0.6 uM), X. vesicatoria 687.3, and X. vesicatoria B229RI (MIC 0.6-1.15 uM) ( Ehret-Sabatier et al., 1996 ). Fungi: Active against fungi C.albicans 315 or B311 (MIC
Evidence 25 Activity

Activity

MIC
Antibacterial
125-500 µg/mL

Target

C.albicans 315 or B311

Source & Reference

dbAMP DRAMP

Other

ria B229RI (MIC 0.6-1.15 uM) ( Ehret-Sabatier et al., 1996 ). Fungi: Active against fungi C.albicans 315 or B311 (MIC 125-500 ug/ml), C.glabrata 359 (MIC 500 ug/ml), C.krusei 355 (MIC 125 ug/ml), C. neoformans 316 (MIC 62.
Evidence 26 Activity

Activity

MIC
Antibacterial
500 µg/mL

Target

C.glabrata 359

Source & Reference

dbAMP DRAMP

Other

r et al., 1996 ). Fungi: Active against fungi C.albicans 315 or B311 (MIC 125-500 ug/ml), C.glabrata 359 (MIC 500 ug/ml), C.krusei 355 (MIC 125 ug/ml), C. neoformans 316 (MIC 62.5 ug/ml), and A.fumigatus X 8072
Evidence 27 Activity

Activity

MIC
Antibacterial
125 µg/mL

Target

C.krusei 355

Source & Reference

dbAMP DRAMP

Other

against fungi C.albicans 315 or B311 (MIC 125-500 ug/ml), C.glabrata 359 (MIC 500 ug/ml), C.krusei 355 (MIC 125 ug/ml), C. neoformans 316 (MIC 62.5 ug/ml), and A.fumigatus X 807219 (MIC 125 ug/ml) ( van't Hof
Evidence 28 Activity

Activity

MIC
Antibacterial
62.5 µg/mL

Target

C. neoformans 316

Source & Reference

dbAMP DRAMP

Other

r B311 (MIC 125-500 ug/ml), C.glabrata 359 (MIC 500 ug/ml), C.krusei 355 (MIC 125 ug/ml), C. neoformans 316 (MIC 62.5 ug/ml), and A.fumigatus X 807219 (MIC 125 ug/ml) ( van't Hof et al., 2000 ). Antimalarial: P. fa
Evidence 29 Activity

Activity

MIC
Antibacterial
125 µg/mL

Target

A.fumigatus X 807219

Source & Reference

dbAMP DRAMP

Other

59 (MIC 500 ug/ml), C.krusei 355 (MIC 125 ug/ml), C. neoformans 316 (MIC 62.5 ug/ml), and A.fumigatus X 807219 (MIC 125 ug/ml) ( van't Hof et al., 2000 ). Antimalarial: P. falciparium (IC50 <50 uM) (see AP4787).
Evidence 30 Activity

Activity

IC50
Antibacterial
<50 µM

Target

P. falciparium

Source & Reference

dbAMP DRAMP

Other

g/ml), and A.fumigatus X 807219 (MIC 125 ug/ml) ( van't Hof et al., 2000 ). Antimalarial: P. falciparium (IC50 <50 uM) (see AP4787).
Evidence 31 Activity

Activity

MIC
Antifungal
6-25 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Activity was demonstrated in 1988 (see ref). Active against E. coli ATCC 25922 (MIC 6-25 uM), P.aeruginosa ATCC 27883 (MIC 200-500 ug/ml), S. aureus ATCC 25923 or MRSA (MIC 25-50 uM)
Evidence 32 Activity

Activity

MIC
Antifungal
200-500 µg/mL

Target

P.aeruginosa ATCC 27883

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

vity was demonstrated in 1988 (see ref). Active against E. coli ATCC 25922 (MIC 6-25 uM), P.aeruginosa ATCC 27883 (MIC 200-500 ug/ml), S. aureus ATCC 25923 or MRSA (MIC 25-50 uM)c, S. pyogenes ATCC 19615 (MIC 10-50 ug/ml),
Evidence 33 Activity

Activity

MIC
Antifungal
25-50 µM

Target

Staphylococcus aureus ATCC 25923 or MRSA

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ve against E. coli ATCC 25922 (MIC 6-25 uM), P.aeruginosa ATCC 27883 (MIC 200-500 ug/ml), S. aureus ATCC 25923 or MRSA (MIC 25-50 uM)c, S. pyogenes ATCC 19615 (MIC 10-50 ug/ml), S. cerevisiae ATCC A3180, and C.albicans (MIC
Evidence 34 Activity

Activity

MIC
Antifungal
10-50 µg/mL

Target

Streptococcus pyogenes ATCC 19615

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

.aeruginosa ATCC 27883 (MIC 200-500 ug/ml), S. aureus ATCC 25923 or MRSA (MIC 25-50 uM)c, S. pyogenes ATCC 19615 (MIC 10-50 ug/ml), S. cerevisiae ATCC A3180, and C.albicans (MIC 100-200 ug/ml). protozoan P. caudatum (min
Evidence 35 Activity

Activity

MIC
Antifungal
100-200 µg/mL

Target

C.albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

(MIC 25-50 uM)c, S. pyogenes ATCC 19615 (MIC 10-50 ug/ml), S. cerevisiae ATCC A3180, and C.albicans (MIC 100-200 ug/ml). protozoan P. caudatum (minimal disruptive conc MDC 5 ug/ml), A. castellani (MDC 2 ug/ml)
Evidence 36 Activity

Activity

MIC
Antifungal
0.6-1.2 µM

Target

A. viridans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

/ml), A. castellani (MDC 2 ug/ml), and T. pyriformis (MDC 20 ug/ml). Active against Gram+ A. viridans (MIC 0.6-1.2 uM), M. luteus (MIC 0.3-0.6 uM), B. megaterium (MIC 1.3-2.6 uM), B. subtilis (MIC 0.6-1.3 uM)
Evidence 37 Activity

Activity

MIC
Antifungal
0.3-0.6 µM

Target

M. luteus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ml), and T. pyriformis (MDC 20 ug/ml). Active against Gram+ A. viridans (MIC 0.6-1.2 uM), M. luteus (MIC 0.3-0.6 uM), B. megaterium (MIC 1.3-2.6 uM), B. subtilis (MIC 0.6-1.3 uM), S. aureus (MIC 1.3-2.6 uM)
Evidence 38 Activity

Activity

MIC
Antifungal
1.3-2.6 µM

Target

B. megaterium

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

20 ug/ml). Active against Gram+ A. viridans (MIC 0.6-1.2 uM), M. luteus (MIC 0.3-0.6 uM), B. megaterium (MIC 1.3-2.6 uM), B. subtilis (MIC 0.6-1.3 uM), S. aureus (MIC 1.3-2.6 uM), P. acidolactici (MIC 1.3-2.6 u
Evidence 39 Activity

Activity

MIC
Antifungal
0.6-1.3 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

A. viridans (MIC 0.6-1.2 uM), M. luteus (MIC 0.3-0.6 uM), B. megaterium (MIC 1.3-2.6 uM), B. subtilis (MIC 0.6-1.3 uM), S. aureus (MIC 1.3-2.6 uM), P. acidolactici (MIC 1.3-2.6 uM), Gram- E. coli (MIC 1.3-2.6
Evidence 40 Activity

Activity

MIC
Antifungal
1.3-2.6 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

M. luteus (MIC 0.3-0.6 uM), B. megaterium (MIC 1.3-2.6 uM), B. subtilis (MIC 0.6-1.3 uM), S. aureus (MIC 1.3-2.6 uM), P. acidolactici (MIC 1.3-2.6 uM), Gram- E. coli (MIC 1.3-2.6 uM), S. typhimuriumn (MIC 5
Evidence 41 Activity

Activity

MIC
Antifungal
1.3-2.6 µM

Target

P. acidolactici

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

B. megaterium (MIC 1.3-2.6 uM), B. subtilis (MIC 0.6-1.3 uM), S. aureus (MIC 1.3-2.6 uM), P. acidolactici (MIC 1.3-2.6 uM), Gram- E. coli (MIC 1.3-2.6 uM), S. typhimuriumn (MIC 5.2-52 uM), K pneumoniae (MIC 1.3-2
Evidence 42 Activity

Activity

MIC
Antifungal
1.3-2.6 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

lis (MIC 0.6-1.3 uM), S. aureus (MIC 1.3-2.6 uM), P. acidolactici (MIC 1.3-2.6 uM), Gram- E. coli (MIC 1.3-2.6 uM), S. typhimuriumn (MIC 5.2-52 uM), K pneumoniae (MIC 1.3-2.6 uM), E. cloacae (MIC 1.3-2.6
Evidence 43 Activity

Activity

MIC
Antifungal
5.2-52 µM

Target

S. typhimuriumn

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ureus (MIC 1.3-2.6 uM), P. acidolactici (MIC 1.3-2.6 uM), Gram- E. coli (MIC 1.3-2.6 uM), S. typhimuriumn (MIC 5.2-52 uM), K pneumoniae (MIC 1.3-2.6 uM), E. cloacae (MIC 1.3-2.6 uM), E. carotovora (MIC 1.3-2.6 u
Evidence 44 Activity

Activity

MIC
Antifungal
1.3-2.6 µM

Target

Enterobacter cloacae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

E. coli (MIC 1.3-2.6 uM), S. typhimuriumn (MIC 5.2-52 uM), K pneumoniae (MIC 1.3-2.6 uM), E. cloacae (MIC 1.3-2.6 uM), E. carotovora (MIC 1.3-2.6 uM), P. aeruginosa (MIC 5.2-52 uM) (see ref for Thanatin). Ac
Evidence 45 Activity

Activity

MIC
Antifungal
1.3-2.6 µM

Target

E. carotovora

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

typhimuriumn (MIC 5.2-52 uM), K pneumoniae (MIC 1.3-2.6 uM), E. cloacae (MIC 1.3-2.6 uM), E. carotovora (MIC 1.3-2.6 uM), P. aeruginosa (MIC 5.2-52 uM) (see ref for Thanatin). Active against B. dendrobatidis (T
Evidence 46 Activity

Activity

MIC
Antifungal
5.2-52 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

pneumoniae (MIC 1.3-2.6 uM), E. cloacae (MIC 1.3-2.6 uM), E. carotovora (MIC 1.3-2.6 uM), P. aeruginosa (MIC 5.2-52 uM) (see ref for Thanatin). Active against B. dendrobatidis (Table 1, Rollins-Smith, BBA 2009
Evidence 47 Activity

Activity

MIC
Antifungal
2.3-4.6 µM

Target

B. cereus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ndrobatidis (Table 1, Rollins-Smith, BBA 2009 1788:1593-1599). ALso active against Gram+ B. cereus (MIC 2.3-4.6 uM), B. thuringiensis (MIC 4.6-46 uM), C. michiganensis (MIC 1.15-2.3 uM), Gram- P. cepacia,
Evidence 48 Activity

Activity

MIC
Antifungal
4.6-46 µM

Target

B. thuringiensis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

s-Smith, BBA 2009 1788:1593-1599). ALso active against Gram+ B. cereus (MIC 2.3-4.6 uM), B. thuringiensis (MIC 4.6-46 uM), C. michiganensis (MIC 1.15-2.3 uM), Gram- P. cepacia, P. syringae, P. syringae pv. syrin
Evidence 49 Activity

Activity

MIC
Antifungal
1.15-2.3 µM

Target

C. michiganensis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

. ALso active against Gram+ B. cereus (MIC 2.3-4.6 uM), B. thuringiensis (MIC 4.6-46 uM), C. michiganensis (MIC 1.15-2.3 uM), Gram- P. cepacia, P. syringae, P. syringae pv. syringae, P. syringae phaseoli (MIC 1.15-
Evidence 50 Activity

Activity

MIC
Antifungal
1.15-2.3 µM

Target

P. syringae phaseoli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

michiganensis (MIC 1.15-2.3 uM), Gram- P. cepacia, P. syringae, P. syringae pv. syringae, P. syringae phaseoli (MIC 1.15-2.3 uM), P. pisi (MIC 0.6-1.15 uM), P-maculicola, P-valerianella (MIC >30 uM), X. campestris pv.
Evidence 51 Activity

Activity

MIC
Antifungal
0.6-1.15 µM

Target

P. pisi

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

. cepacia, P. syringae, P. syringae pv. syringae, P. syringae phaseoli (MIC 1.15-2.3 uM), P. pisi (MIC 0.6-1.15 uM), P-maculicola, P-valerianella (MIC >30 uM), X. campestris pv. oryzae (MIC 4.6-46 uM), X.
Evidence 52 Activity

Activity

MIC
Antifungal
4.6-46 µM

Target

v. oryzae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

uM), P. pisi (MIC 0.6-1.15 uM), P-maculicola, P-valerianella (MIC >30 uM), X. campestris pv. oryzae (MIC 4.6-46 uM), X. campestris pv. campestris (MIC 0.3-0.6 uM), X. vesicatoria 687.3, and X. vesicatoria
Evidence 53 Activity

Activity

MIC
Antifungal
0.3-0.6 µM

Target

v. campestris

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

la, P-valerianella (MIC >30 uM), X. campestris pv. oryzae (MIC 4.6-46 uM), X. campestris pv. campestris (MIC 0.3-0.6 uM), X. vesicatoria 687.3, and X. vesicatoria B229RI (MIC 0.6-1.15 uM) ( Ehret-Sabatier et al
Evidence 54 Activity

Activity

MIC
Antifungal
0.6-1.15 µM

Target

X. vesicatoria B229RI

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

(MIC 4.6-46 uM), X. campestris pv. campestris (MIC 0.3-0.6 uM), X. vesicatoria 687.3, and X. vesicatoria B229RI (MIC 0.6-1.15 uM) ( Ehret-Sabatier et al., 1996 ). Fungi: Active against fungi C.albicans 315 or B311 (MIC
Evidence 55 Activity

Activity

MIC
Antifungal
125-500 µg/mL

Target

C.albicans 315 or B311

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ria B229RI (MIC 0.6-1.15 uM) ( Ehret-Sabatier et al., 1996 ). Fungi: Active against fungi C.albicans 315 or B311 (MIC 125-500 ug/ml), C.glabrata 359 (MIC 500 ug/ml), C.krusei 355 (MIC 125 ug/ml), C. neoformans 316 (MIC 62.
Evidence 56 Activity

Activity

MIC
Antifungal
500 µg/mL

Target

C.glabrata 359

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

r et al., 1996 ). Fungi: Active against fungi C.albicans 315 or B311 (MIC 125-500 ug/ml), C.glabrata 359 (MIC 500 ug/ml), C.krusei 355 (MIC 125 ug/ml), C. neoformans 316 (MIC 62.5 ug/ml), and A.fumigatus X 8072
Evidence 57 Activity

Activity

MIC
Antifungal
125 µg/mL

Target

C.krusei 355

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

against fungi C.albicans 315 or B311 (MIC 125-500 ug/ml), C.glabrata 359 (MIC 500 ug/ml), C.krusei 355 (MIC 125 ug/ml), C. neoformans 316 (MIC 62.5 ug/ml), and A.fumigatus X 807219 (MIC 125 ug/ml) ( van't Hof
Evidence 58 Activity

Activity

MIC
Antifungal
62.5 µg/mL

Target

C. neoformans 316

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

r B311 (MIC 125-500 ug/ml), C.glabrata 359 (MIC 500 ug/ml), C.krusei 355 (MIC 125 ug/ml), C. neoformans 316 (MIC 62.5 ug/ml), and A.fumigatus X 807219 (MIC 125 ug/ml) ( van't Hof et al., 2000 ). Antimalarial: P. fa
Evidence 59 Activity

Activity

MIC
Antifungal
125 µg/mL

Target

A.fumigatus X 807219

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

59 (MIC 500 ug/ml), C.krusei 355 (MIC 125 ug/ml), C. neoformans 316 (MIC 62.5 ug/ml), and A.fumigatus X 807219 (MIC 125 ug/ml) ( van't Hof et al., 2000 ). Antimalarial: P. falciparium (IC50 <50 uM) (see AP4787).
Evidence 60 Activity

Activity

IC50
Antifungal
<50 µM

Target

P. falciparium

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

g/ml), and A.fumigatus X 807219 (MIC 125 ug/ml) ( van't Hof et al., 2000 ). Antimalarial: P. falciparium (IC50 <50 uM) (see AP4787).
Evidence 61 Activity

Activity

MIC
Antiparasitic
6-25 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
Activity was demonstrated in 1988 (see ref). Active against E. coli ATCC 25922 (MIC 6-25 uM), P.aeruginosa ATCC 27883 (MIC 200-500 ug/ml), S. aureus ATCC 25923 or MRSA (MIC 25-50 uM)
Evidence 62 Activity

Activity

MIC
Antiparasitic
200-500 µg/mL

Target

P.aeruginosa ATCC 27883

Source & Reference

dbAMP 3.0 DRAMP

Other

vity was demonstrated in 1988 (see ref). Active against E. coli ATCC 25922 (MIC 6-25 uM), P.aeruginosa ATCC 27883 (MIC 200-500 ug/ml), S. aureus ATCC 25923 or MRSA (MIC 25-50 uM)c, S. pyogenes ATCC 19615 (MIC 10-50 ug/ml),
Evidence 63 Activity

Activity

MIC
Antiparasitic
25-50 µM

Target

Staphylococcus aureus ATCC 25923 or MRSA

Source & Reference

dbAMP 3.0 DRAMP

Other

ve against E. coli ATCC 25922 (MIC 6-25 uM), P.aeruginosa ATCC 27883 (MIC 200-500 ug/ml), S. aureus ATCC 25923 or MRSA (MIC 25-50 uM)c, S. pyogenes ATCC 19615 (MIC 10-50 ug/ml), S. cerevisiae ATCC A3180, and C.albicans (MIC
Evidence 64 Activity

Activity

MIC
Antiparasitic
10-50 µg/mL

Target

Streptococcus pyogenes ATCC 19615

Source & Reference

dbAMP 3.0 DRAMP

Other

.aeruginosa ATCC 27883 (MIC 200-500 ug/ml), S. aureus ATCC 25923 or MRSA (MIC 25-50 uM)c, S. pyogenes ATCC 19615 (MIC 10-50 ug/ml), S. cerevisiae ATCC A3180, and C.albicans (MIC 100-200 ug/ml). protozoan P. caudatum (min
Evidence 65 Activity

Activity

MIC
Antiparasitic
100-200 µg/mL

Target

C.albicans

Source & Reference

dbAMP 3.0 DRAMP

Other

(MIC 25-50 uM)c, S. pyogenes ATCC 19615 (MIC 10-50 ug/ml), S. cerevisiae ATCC A3180, and C.albicans (MIC 100-200 ug/ml). protozoan P. caudatum (minimal disruptive conc MDC 5 ug/ml), A. castellani (MDC 2 ug/ml)
Evidence 66 Activity

Activity

MIC
Antiparasitic
0.6-1.2 µM

Target

A. viridans

Source & Reference

dbAMP 3.0 DRAMP

Other

/ml), A. castellani (MDC 2 ug/ml), and T. pyriformis (MDC 20 ug/ml). Active against Gram+ A. viridans (MIC 0.6-1.2 uM), M. luteus (MIC 0.3-0.6 uM), B. megaterium (MIC 1.3-2.6 uM), B. subtilis (MIC 0.6-1.3 uM)
Evidence 67 Activity

Activity

MIC
Antiparasitic
0.3-0.6 µM

Target

M. luteus

Source & Reference

dbAMP 3.0 DRAMP

Other

ml), and T. pyriformis (MDC 20 ug/ml). Active against Gram+ A. viridans (MIC 0.6-1.2 uM), M. luteus (MIC 0.3-0.6 uM), B. megaterium (MIC 1.3-2.6 uM), B. subtilis (MIC 0.6-1.3 uM), S. aureus (MIC 1.3-2.6 uM)
Evidence 68 Activity

Activity

MIC
Antiparasitic
1.3-2.6 µM

Target

B. megaterium

Source & Reference

dbAMP 3.0 DRAMP

Other

20 ug/ml). Active against Gram+ A. viridans (MIC 0.6-1.2 uM), M. luteus (MIC 0.3-0.6 uM), B. megaterium (MIC 1.3-2.6 uM), B. subtilis (MIC 0.6-1.3 uM), S. aureus (MIC 1.3-2.6 uM), P. acidolactici (MIC 1.3-2.6 u
Evidence 69 Activity

Activity

MIC
Antiparasitic
0.6-1.3 µM

Target

B. subtilis

Source & Reference

dbAMP 3.0 DRAMP

Other

A. viridans (MIC 0.6-1.2 uM), M. luteus (MIC 0.3-0.6 uM), B. megaterium (MIC 1.3-2.6 uM), B. subtilis (MIC 0.6-1.3 uM), S. aureus (MIC 1.3-2.6 uM), P. acidolactici (MIC 1.3-2.6 uM), Gram- E. coli (MIC 1.3-2.6
Evidence 70 Activity

Activity

MIC
Antiparasitic
1.3-2.6 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP 3.0 DRAMP

Other

M. luteus (MIC 0.3-0.6 uM), B. megaterium (MIC 1.3-2.6 uM), B. subtilis (MIC 0.6-1.3 uM), S. aureus (MIC 1.3-2.6 uM), P. acidolactici (MIC 1.3-2.6 uM), Gram- E. coli (MIC 1.3-2.6 uM), S. typhimuriumn (MIC 5
Evidence 71 Activity

Activity

MIC
Antiparasitic
1.3-2.6 µM

Target

P. acidolactici

Source & Reference

dbAMP 3.0 DRAMP

Other

B. megaterium (MIC 1.3-2.6 uM), B. subtilis (MIC 0.6-1.3 uM), S. aureus (MIC 1.3-2.6 uM), P. acidolactici (MIC 1.3-2.6 uM), Gram- E. coli (MIC 1.3-2.6 uM), S. typhimuriumn (MIC 5.2-52 uM), K pneumoniae (MIC 1.3-2
Evidence 72 Activity

Activity

MIC
Antiparasitic
1.3-2.6 µM

Target

Escherichia coli

Source & Reference

dbAMP 3.0 DRAMP

Other

lis (MIC 0.6-1.3 uM), S. aureus (MIC 1.3-2.6 uM), P. acidolactici (MIC 1.3-2.6 uM), Gram- E. coli (MIC 1.3-2.6 uM), S. typhimuriumn (MIC 5.2-52 uM), K pneumoniae (MIC 1.3-2.6 uM), E. cloacae (MIC 1.3-2.6
Evidence 73 Activity

Activity

MIC
Antiparasitic
5.2-52 µM

Target

S. typhimuriumn

Source & Reference

dbAMP 3.0 DRAMP

Other

ureus (MIC 1.3-2.6 uM), P. acidolactici (MIC 1.3-2.6 uM), Gram- E. coli (MIC 1.3-2.6 uM), S. typhimuriumn (MIC 5.2-52 uM), K pneumoniae (MIC 1.3-2.6 uM), E. cloacae (MIC 1.3-2.6 uM), E. carotovora (MIC 1.3-2.6 u
Evidence 74 Activity

Activity

MIC
Antiparasitic
1.3-2.6 µM

Target

Enterobacter cloacae

Source & Reference

dbAMP 3.0 DRAMP

Other

E. coli (MIC 1.3-2.6 uM), S. typhimuriumn (MIC 5.2-52 uM), K pneumoniae (MIC 1.3-2.6 uM), E. cloacae (MIC 1.3-2.6 uM), E. carotovora (MIC 1.3-2.6 uM), P. aeruginosa (MIC 5.2-52 uM) (see ref for Thanatin). Ac
Evidence 75 Activity

Activity

MIC
Antiparasitic
1.3-2.6 µM

Target

E. carotovora

Source & Reference

dbAMP 3.0 DRAMP

Other

typhimuriumn (MIC 5.2-52 uM), K pneumoniae (MIC 1.3-2.6 uM), E. cloacae (MIC 1.3-2.6 uM), E. carotovora (MIC 1.3-2.6 uM), P. aeruginosa (MIC 5.2-52 uM) (see ref for Thanatin). Active against B. dendrobatidis (T
Evidence 76 Activity

Activity

MIC
Antiparasitic
5.2-52 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP 3.0 DRAMP

Other

pneumoniae (MIC 1.3-2.6 uM), E. cloacae (MIC 1.3-2.6 uM), E. carotovora (MIC 1.3-2.6 uM), P. aeruginosa (MIC 5.2-52 uM) (see ref for Thanatin). Active against B. dendrobatidis (Table 1, Rollins-Smith, BBA 2009
Evidence 77 Activity

Activity

MIC
Antiparasitic
2.3-4.6 µM

Target

B. cereus

Source & Reference

dbAMP 3.0 DRAMP

Other

ndrobatidis (Table 1, Rollins-Smith, BBA 2009 1788:1593-1599). ALso active against Gram+ B. cereus (MIC 2.3-4.6 uM), B. thuringiensis (MIC 4.6-46 uM), C. michiganensis (MIC 1.15-2.3 uM), Gram- P. cepacia,
Evidence 78 Activity

Activity

MIC
Antiparasitic
4.6-46 µM

Target

B. thuringiensis

Source & Reference

dbAMP 3.0 DRAMP

Other

s-Smith, BBA 2009 1788:1593-1599). ALso active against Gram+ B. cereus (MIC 2.3-4.6 uM), B. thuringiensis (MIC 4.6-46 uM), C. michiganensis (MIC 1.15-2.3 uM), Gram- P. cepacia, P. syringae, P. syringae pv. syrin
Evidence 79 Activity

Activity

MIC
Antiparasitic
1.15-2.3 µM

Target

C. michiganensis

Source & Reference

dbAMP 3.0 DRAMP

Other

. ALso active against Gram+ B. cereus (MIC 2.3-4.6 uM), B. thuringiensis (MIC 4.6-46 uM), C. michiganensis (MIC 1.15-2.3 uM), Gram- P. cepacia, P. syringae, P. syringae pv. syringae, P. syringae phaseoli (MIC 1.15-
Evidence 80 Activity

Activity

MIC
Antiparasitic
1.15-2.3 µM

Target

P. syringae phaseoli

Source & Reference

dbAMP 3.0 DRAMP

Other

michiganensis (MIC 1.15-2.3 uM), Gram- P. cepacia, P. syringae, P. syringae pv. syringae, P. syringae phaseoli (MIC 1.15-2.3 uM), P. pisi (MIC 0.6-1.15 uM), P-maculicola, P-valerianella (MIC >30 uM), X. campestris pv.
Evidence 81 Activity

Activity

MIC
Antiparasitic
0.6-1.15 µM

Target

P. pisi

Source & Reference

dbAMP 3.0 DRAMP

Other

. cepacia, P. syringae, P. syringae pv. syringae, P. syringae phaseoli (MIC 1.15-2.3 uM), P. pisi (MIC 0.6-1.15 uM), P-maculicola, P-valerianella (MIC >30 uM), X. campestris pv. oryzae (MIC 4.6-46 uM), X.
Evidence 82 Activity

Activity

MIC
Antiparasitic
4.6-46 µM

Target

v. oryzae

Source & Reference

dbAMP 3.0 DRAMP

Other

uM), P. pisi (MIC 0.6-1.15 uM), P-maculicola, P-valerianella (MIC >30 uM), X. campestris pv. oryzae (MIC 4.6-46 uM), X. campestris pv. campestris (MIC 0.3-0.6 uM), X. vesicatoria 687.3, and X. vesicatoria
Evidence 83 Activity

Activity

MIC
Antiparasitic
0.3-0.6 µM

Target

v. campestris

Source & Reference

dbAMP 3.0 DRAMP

Other

la, P-valerianella (MIC >30 uM), X. campestris pv. oryzae (MIC 4.6-46 uM), X. campestris pv. campestris (MIC 0.3-0.6 uM), X. vesicatoria 687.3, and X. vesicatoria B229RI (MIC 0.6-1.15 uM) ( Ehret-Sabatier et al
Evidence 84 Activity

Activity

MIC
Antiparasitic
0.6-1.15 µM

Target

X. vesicatoria B229RI

Source & Reference

dbAMP 3.0 DRAMP

Other

(MIC 4.6-46 uM), X. campestris pv. campestris (MIC 0.3-0.6 uM), X. vesicatoria 687.3, and X. vesicatoria B229RI (MIC 0.6-1.15 uM) ( Ehret-Sabatier et al., 1996 ). Fungi: Active against fungi C.albicans 315 or B311 (MIC
Evidence 85 Activity

Activity

MIC
Antiparasitic
125-500 µg/mL

Target

C.albicans 315 or B311

Source & Reference

dbAMP 3.0 DRAMP

Other

ria B229RI (MIC 0.6-1.15 uM) ( Ehret-Sabatier et al., 1996 ). Fungi: Active against fungi C.albicans 315 or B311 (MIC 125-500 ug/ml), C.glabrata 359 (MIC 500 ug/ml), C.krusei 355 (MIC 125 ug/ml), C. neoformans 316 (MIC 62.
Evidence 86 Activity

Activity

MIC
Antiparasitic
500 µg/mL

Target

C.glabrata 359

Source & Reference

dbAMP 3.0 DRAMP

Other

r et al., 1996 ). Fungi: Active against fungi C.albicans 315 or B311 (MIC 125-500 ug/ml), C.glabrata 359 (MIC 500 ug/ml), C.krusei 355 (MIC 125 ug/ml), C. neoformans 316 (MIC 62.5 ug/ml), and A.fumigatus X 8072
Evidence 87 Activity

Activity

MIC
Antiparasitic
125 µg/mL

Target

C.krusei 355

Source & Reference

dbAMP 3.0 DRAMP

Other

against fungi C.albicans 315 or B311 (MIC 125-500 ug/ml), C.glabrata 359 (MIC 500 ug/ml), C.krusei 355 (MIC 125 ug/ml), C. neoformans 316 (MIC 62.5 ug/ml), and A.fumigatus X 807219 (MIC 125 ug/ml) ( van't Hof
Evidence 88 Activity

Activity

MIC
Antiparasitic
62.5 µg/mL

Target

C. neoformans 316

Source & Reference

dbAMP 3.0 DRAMP

Other

r B311 (MIC 125-500 ug/ml), C.glabrata 359 (MIC 500 ug/ml), C.krusei 355 (MIC 125 ug/ml), C. neoformans 316 (MIC 62.5 ug/ml), and A.fumigatus X 807219 (MIC 125 ug/ml) ( van't Hof et al., 2000 ). Antimalarial: P. fa
Evidence 89 Activity

Activity

MIC
Antiparasitic
125 µg/mL

Target

A.fumigatus X 807219

Source & Reference

dbAMP 3.0 DRAMP

Other

59 (MIC 500 ug/ml), C.krusei 355 (MIC 125 ug/ml), C. neoformans 316 (MIC 62.5 ug/ml), and A.fumigatus X 807219 (MIC 125 ug/ml) ( van't Hof et al., 2000 ). Antimalarial: P. falciparium (IC50 <50 uM) (see AP4787).
Evidence 90 Activity

Activity

IC50
Antiparasitic
<50 µM

Target

P. falciparium

Source & Reference

dbAMP 3.0 DRAMP

Other

g/ml), and A.fumigatus X 807219 (MIC 125 ug/ml) ( van't Hof et al., 2000 ). Antimalarial: P. falciparium (IC50 <50 uM) (see AP4787).
Evidence 91 Activity

Activity

MIC
Antiviral
6-25 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.
Activity was demonstrated in 1988 (see ref). Active against E. coli ATCC 25922 (MIC 6-25 uM), P.aeruginosa ATCC 27883 (MIC 200-500 ug/ml), S. aureus ATCC 25923 or MRSA (MIC 25-50 uM)
Evidence 92 Activity

Activity

MIC
Antiviral
200-500 µg/mL

Target

P.aeruginosa ATCC 27883

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

vity was demonstrated in 1988 (see ref). Active against E. coli ATCC 25922 (MIC 6-25 uM), P.aeruginosa ATCC 27883 (MIC 200-500 ug/ml), S. aureus ATCC 25923 or MRSA (MIC 25-50 uM)c, S. pyogenes ATCC 19615 (MIC 10-50 ug/ml),
Evidence 93 Activity

Activity

MIC
Antiviral
25-50 µM

Target

Staphylococcus aureus ATCC 25923 or MRSA

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

ve against E. coli ATCC 25922 (MIC 6-25 uM), P.aeruginosa ATCC 27883 (MIC 200-500 ug/ml), S. aureus ATCC 25923 or MRSA (MIC 25-50 uM)c, S. pyogenes ATCC 19615 (MIC 10-50 ug/ml), S. cerevisiae ATCC A3180, and C.albicans (MIC
Evidence 94 Activity

Activity

MIC
Antiviral
10-50 µg/mL

Target

Streptococcus pyogenes ATCC 19615

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

.aeruginosa ATCC 27883 (MIC 200-500 ug/ml), S. aureus ATCC 25923 or MRSA (MIC 25-50 uM)c, S. pyogenes ATCC 19615 (MIC 10-50 ug/ml), S. cerevisiae ATCC A3180, and C.albicans (MIC 100-200 ug/ml). protozoan P. caudatum (min
Evidence 95 Activity

Activity

MIC
Antiviral
100-200 µg/mL

Target

C.albicans

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

(MIC 25-50 uM)c, S. pyogenes ATCC 19615 (MIC 10-50 ug/ml), S. cerevisiae ATCC A3180, and C.albicans (MIC 100-200 ug/ml). protozoan P. caudatum (minimal disruptive conc MDC 5 ug/ml), A. castellani (MDC 2 ug/ml)
Evidence 96 Activity

Activity

MIC
Antiviral
0.6-1.2 µM

Target

A. viridans

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

/ml), A. castellani (MDC 2 ug/ml), and T. pyriformis (MDC 20 ug/ml). Active against Gram+ A. viridans (MIC 0.6-1.2 uM), M. luteus (MIC 0.3-0.6 uM), B. megaterium (MIC 1.3-2.6 uM), B. subtilis (MIC 0.6-1.3 uM)
Evidence 97 Activity

Activity

MIC
Antiviral
0.3-0.6 µM

Target

M. luteus

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

ml), and T. pyriformis (MDC 20 ug/ml). Active against Gram+ A. viridans (MIC 0.6-1.2 uM), M. luteus (MIC 0.3-0.6 uM), B. megaterium (MIC 1.3-2.6 uM), B. subtilis (MIC 0.6-1.3 uM), S. aureus (MIC 1.3-2.6 uM)
Evidence 98 Activity

Activity

MIC
Antiviral
1.3-2.6 µM

Target

B. megaterium

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

20 ug/ml). Active against Gram+ A. viridans (MIC 0.6-1.2 uM), M. luteus (MIC 0.3-0.6 uM), B. megaterium (MIC 1.3-2.6 uM), B. subtilis (MIC 0.6-1.3 uM), S. aureus (MIC 1.3-2.6 uM), P. acidolactici (MIC 1.3-2.6 u
Evidence 99 Activity

Activity

MIC
Antiviral
0.6-1.3 µM

Target

B. subtilis

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

A. viridans (MIC 0.6-1.2 uM), M. luteus (MIC 0.3-0.6 uM), B. megaterium (MIC 1.3-2.6 uM), B. subtilis (MIC 0.6-1.3 uM), S. aureus (MIC 1.3-2.6 uM), P. acidolactici (MIC 1.3-2.6 uM), Gram- E. coli (MIC 1.3-2.6
Evidence 100 Activity

Activity

MIC
Antiviral
1.3-2.6 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

M. luteus (MIC 0.3-0.6 uM), B. megaterium (MIC 1.3-2.6 uM), B. subtilis (MIC 0.6-1.3 uM), S. aureus (MIC 1.3-2.6 uM), P. acidolactici (MIC 1.3-2.6 uM), Gram- E. coli (MIC 1.3-2.6 uM), S. typhimuriumn (MIC 5
Evidence 101 Activity

Activity

MIC
Antiviral
1.3-2.6 µM

Target

P. acidolactici

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

B. megaterium (MIC 1.3-2.6 uM), B. subtilis (MIC 0.6-1.3 uM), S. aureus (MIC 1.3-2.6 uM), P. acidolactici (MIC 1.3-2.6 uM), Gram- E. coli (MIC 1.3-2.6 uM), S. typhimuriumn (MIC 5.2-52 uM), K pneumoniae (MIC 1.3-2
Evidence 102 Activity

Activity

MIC
Antiviral
1.3-2.6 µM

Target

Escherichia coli

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

lis (MIC 0.6-1.3 uM), S. aureus (MIC 1.3-2.6 uM), P. acidolactici (MIC 1.3-2.6 uM), Gram- E. coli (MIC 1.3-2.6 uM), S. typhimuriumn (MIC 5.2-52 uM), K pneumoniae (MIC 1.3-2.6 uM), E. cloacae (MIC 1.3-2.6
Evidence 103 Activity

Activity

MIC
Antiviral
5.2-52 µM

Target

S. typhimuriumn

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

ureus (MIC 1.3-2.6 uM), P. acidolactici (MIC 1.3-2.6 uM), Gram- E. coli (MIC 1.3-2.6 uM), S. typhimuriumn (MIC 5.2-52 uM), K pneumoniae (MIC 1.3-2.6 uM), E. cloacae (MIC 1.3-2.6 uM), E. carotovora (MIC 1.3-2.6 u
Evidence 104 Activity

Activity

MIC
Antiviral
1.3-2.6 µM

Target

Enterobacter cloacae

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

E. coli (MIC 1.3-2.6 uM), S. typhimuriumn (MIC 5.2-52 uM), K pneumoniae (MIC 1.3-2.6 uM), E. cloacae (MIC 1.3-2.6 uM), E. carotovora (MIC 1.3-2.6 uM), P. aeruginosa (MIC 5.2-52 uM) (see ref for Thanatin). Ac
Evidence 105 Activity

Activity

MIC
Antiviral
1.3-2.6 µM

Target

E. carotovora

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

typhimuriumn (MIC 5.2-52 uM), K pneumoniae (MIC 1.3-2.6 uM), E. cloacae (MIC 1.3-2.6 uM), E. carotovora (MIC 1.3-2.6 uM), P. aeruginosa (MIC 5.2-52 uM) (see ref for Thanatin). Active against B. dendrobatidis (T
Evidence 106 Activity

Activity

MIC
Antiviral
5.2-52 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

pneumoniae (MIC 1.3-2.6 uM), E. cloacae (MIC 1.3-2.6 uM), E. carotovora (MIC 1.3-2.6 uM), P. aeruginosa (MIC 5.2-52 uM) (see ref for Thanatin). Active against B. dendrobatidis (Table 1, Rollins-Smith, BBA 2009
Evidence 107 Activity

Activity

MIC
Antiviral
2.3-4.6 µM

Target

B. cereus

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

ndrobatidis (Table 1, Rollins-Smith, BBA 2009 1788:1593-1599). ALso active against Gram+ B. cereus (MIC 2.3-4.6 uM), B. thuringiensis (MIC 4.6-46 uM), C. michiganensis (MIC 1.15-2.3 uM), Gram- P. cepacia,
Evidence 108 Activity

Activity

MIC
Antiviral
4.6-46 µM

Target

B. thuringiensis

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

s-Smith, BBA 2009 1788:1593-1599). ALso active against Gram+ B. cereus (MIC 2.3-4.6 uM), B. thuringiensis (MIC 4.6-46 uM), C. michiganensis (MIC 1.15-2.3 uM), Gram- P. cepacia, P. syringae, P. syringae pv. syrin
Evidence 109 Activity

Activity

MIC
Antiviral
1.15-2.3 µM

Target

C. michiganensis

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

. ALso active against Gram+ B. cereus (MIC 2.3-4.6 uM), B. thuringiensis (MIC 4.6-46 uM), C. michiganensis (MIC 1.15-2.3 uM), Gram- P. cepacia, P. syringae, P. syringae pv. syringae, P. syringae phaseoli (MIC 1.15-
Evidence 110 Activity

Activity

MIC
Antiviral
1.15-2.3 µM

Target

P. syringae phaseoli

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

michiganensis (MIC 1.15-2.3 uM), Gram- P. cepacia, P. syringae, P. syringae pv. syringae, P. syringae phaseoli (MIC 1.15-2.3 uM), P. pisi (MIC 0.6-1.15 uM), P-maculicola, P-valerianella (MIC >30 uM), X. campestris pv.
Evidence 111 Activity

Activity

MIC
Antiviral
0.6-1.15 µM

Target

P. pisi

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

. cepacia, P. syringae, P. syringae pv. syringae, P. syringae phaseoli (MIC 1.15-2.3 uM), P. pisi (MIC 0.6-1.15 uM), P-maculicola, P-valerianella (MIC >30 uM), X. campestris pv. oryzae (MIC 4.6-46 uM), X.
Evidence 112 Activity

Activity

MIC
Antiviral
4.6-46 µM

Target

v. oryzae

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

uM), P. pisi (MIC 0.6-1.15 uM), P-maculicola, P-valerianella (MIC >30 uM), X. campestris pv. oryzae (MIC 4.6-46 uM), X. campestris pv. campestris (MIC 0.3-0.6 uM), X. vesicatoria 687.3, and X. vesicatoria
Evidence 113 Activity

Activity

MIC
Antiviral
0.3-0.6 µM

Target

v. campestris

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

la, P-valerianella (MIC >30 uM), X. campestris pv. oryzae (MIC 4.6-46 uM), X. campestris pv. campestris (MIC 0.3-0.6 uM), X. vesicatoria 687.3, and X. vesicatoria B229RI (MIC 0.6-1.15 uM) ( Ehret-Sabatier et al
Evidence 114 Activity

Activity

MIC
Antiviral
0.6-1.15 µM

Target

X. vesicatoria B229RI

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

(MIC 4.6-46 uM), X. campestris pv. campestris (MIC 0.3-0.6 uM), X. vesicatoria 687.3, and X. vesicatoria B229RI (MIC 0.6-1.15 uM) ( Ehret-Sabatier et al., 1996 ). Fungi: Active against fungi C.albicans 315 or B311 (MIC
Evidence 115 Activity

Activity

MIC
Antiviral
125-500 µg/mL

Target

C.albicans 315 or B311

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

ria B229RI (MIC 0.6-1.15 uM) ( Ehret-Sabatier et al., 1996 ). Fungi: Active against fungi C.albicans 315 or B311 (MIC 125-500 ug/ml), C.glabrata 359 (MIC 500 ug/ml), C.krusei 355 (MIC 125 ug/ml), C. neoformans 316 (MIC 62.
Evidence 116 Activity

Activity

MIC
Antiviral
500 µg/mL

Target

C.glabrata 359

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

r et al., 1996 ). Fungi: Active against fungi C.albicans 315 or B311 (MIC 125-500 ug/ml), C.glabrata 359 (MIC 500 ug/ml), C.krusei 355 (MIC 125 ug/ml), C. neoformans 316 (MIC 62.5 ug/ml), and A.fumigatus X 8072
Evidence 117 Activity

Activity

MIC
Antiviral
125 µg/mL

Target

C.krusei 355

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

against fungi C.albicans 315 or B311 (MIC 125-500 ug/ml), C.glabrata 359 (MIC 500 ug/ml), C.krusei 355 (MIC 125 ug/ml), C. neoformans 316 (MIC 62.5 ug/ml), and A.fumigatus X 807219 (MIC 125 ug/ml) ( van't Hof
Evidence 118 Activity

Activity

MIC
Antiviral
62.5 µg/mL

Target

C. neoformans 316

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

r B311 (MIC 125-500 ug/ml), C.glabrata 359 (MIC 500 ug/ml), C.krusei 355 (MIC 125 ug/ml), C. neoformans 316 (MIC 62.5 ug/ml), and A.fumigatus X 807219 (MIC 125 ug/ml) ( van't Hof et al., 2000 ). Antimalarial: P. fa
Evidence 119 Activity

Activity

MIC
Antiviral
125 µg/mL

Target

A.fumigatus X 807219

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

59 (MIC 500 ug/ml), C.krusei 355 (MIC 125 ug/ml), C. neoformans 316 (MIC 62.5 ug/ml), and A.fumigatus X 807219 (MIC 125 ug/ml) ( van't Hof et al., 2000 ). Antimalarial: P. falciparium (IC50 <50 uM) (see AP4787).
Evidence 120 Activity

Activity

IC50
Antiviral
<50 µM

Target

P. falciparium

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

g/ml), and A.fumigatus X 807219 (MIC 125 ug/ml) ( van't Hof et al., 2000 ). Antimalarial: P. falciparium (IC50 <50 uM) (see AP4787).
Evidence 121 Activity

Activity

7% Hemolysis
Toxicity
32-128 µg/mL
Hemolytic Cytotoxic
7% Hemolysis | 32-128 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Influence of C-terminal amidation on the antimicrobial and hemolytic activities of cationic a-helical peptides | Pure Appl Chem | 2007
Evidence 122 Activity

Activity

10% Hemolysis
Toxicity
512-1024 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 512-1024 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Influence of C-terminal amidation on the antimicrobial and hemolytic activities of cationic a-helical peptides | Pure Appl Chem | 2007
Evidence 123 Activity

Activity

1% Hemolysis
Toxicity
500 µg/mL
Hemolytic Cytotoxic
1% Hemolysis | 500 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A novel linear amphipathic beta-sheet cationic antimicrobial peptide with enhanced selectivity for bacterial lipids | J Biol Chem | 2001
Evidence 124 Activity

Activity

50% Hemolysis
Toxicity
0.6±0.1 µM
Hemolytic Cytotoxic
50% Hemolysis | 0.6±0.1 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A critical comparison of the hemolytic and fungicidal activities of cationic antimicrobial peptides | FEBS Lett | 1999
Evidence 125 Activity

Activity

50% Hemolysis
Toxicity
>102 µM
Hemolytic Cytotoxic
50% Hemolysis | >102 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A critical comparison of the hemolytic and fungicidal activities of cationic antimicrobial peptides | FEBS Lett | 1999
Evidence 126 Activity

Activity

50% Cell death
Toxicity
>50.8 µM
Cytotoxic
50% Cell death | >50.8 | µM | target cell: CEM-SS cells

Target

CEM-SS cells

Source & Reference

NA
DBAASP
Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database | Antimicrob Agents Chemother | 2010
Evidence 127 Activity

Activity

2% Hemolysis
Toxicity
32 µg/mL
Hemolytic Cytotoxic
2% Hemolysis | 32 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Influence of C-terminal amidation on the antimicrobial and hemolytic activities of cationic a-helical peptides | Pure Appl Chem | 2007
Evidence 128 Activity

Activity

13% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
13% Hemolysis | 128 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Influence of C-terminal amidation on the antimicrobial and hemolytic activities of cationic a-helical peptides | Pure Appl Chem | 2007
Evidence 129 Activity

Activity

24% Hemolysis
Toxicity
512 µg/mL
Hemolytic Cytotoxic
24% Hemolysis | 512 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Influence of C-terminal amidation on the antimicrobial and hemolytic activities of cationic a-helical peptides | Pure Appl Chem | 2007
Evidence 130 Activity

Activity

61% Hemolysis
Toxicity
1024 µg/mL
Hemolytic Cytotoxic
61% Hemolysis | 1024 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Influence of C-terminal amidation on the antimicrobial and hemolytic activities of cationic a-helical peptides | Pure Appl Chem | 2007
Evidence 131 Activity

Activity

Toxicity
Hemolytic
NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
QSAR Reveals Decreased Lipophilicity of Polar Residues Determines the Selectivity of Antimicrobial Peptide Activity. | ACS Omega | 2024
Evidence 132 Activity

Activity

25% Cytotoxicity
Toxicity
256 µg/mL
Cytotoxic
25% Cytotoxicity | 256 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
QSAR Reveals Decreased Lipophilicity of Polar Residues Determines the Selectivity of Antimicrobial Peptide Activity. | ACS Omega | 2024
Evidence 133 Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.