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Peptide record

TPDB05027

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard

13 amino acids

3D PDB MODEL

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TPDB ID TPDB05027

Activity

Antibacterial Anticancer Antifungal Antiparasitic Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

INWKGIAAMKKLL

FASTA

>TPDB05027|Antibacterial;Anticancer;Antifungal;Antiparasitic;Toxicity|length=13
INWKGIAAMKKLL

Formula C70H120N18O15S1

Absent Amino Acids RDCEQHFPSTYV

Common Amino Acids K

Mass 1485.89

PI 10.84

Basic Residues 3

Acidic Residues 0

Hydrophobic Residues 8

Net Charge +3

Boman Index -0.76

Hydrophobicity 0.431

Aliphatic Index 135.38

Half Life

Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 370.15

Polar Residues 1

number

Amino Acid Distribution

A: 2 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 2 K: 3 M: 1 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0

Length

Formula

C70H120N18O15S1

Mass

1485.89

10.84

Net Charge

Boman Index

-0.76

Hydrophobicity

0.431

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 15 µg/mL

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against E. coli ATCC25922 (MIC 15 ug/ml), S. aureus ATCC2592 (MIC 3.7 uM), and C. albicans ATCC2002 (MIC 7.5 ug/ml).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.7 µM

Target

Target Organism Staphylococcus aureus ATCC2592

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E. coli ATCC25922 (MIC 15 ug/ml), S. aureus ATCC2592 (MIC 3.7 uM), and C. albicans ATCC2002 (MIC 7.5 ug/ml).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 7.5 µg/mL

Target

Target Organism Candida albicans ATCC2002

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E. coli ATCC25922 (MIC 15 ug/ml), S. aureus ATCC2592 (MIC 3.7 uM), and C. albicans ATCC2002 (MIC 7.5 ug/ml).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 15 µg/mL

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against E. coli ATCC25922 (MIC 15 ug/ml), S. aureus ATCC2592 (MIC 3.7 uM), and C. albicans ATCC2002 (MIC 7.5 ug/ml).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 3.7 µM

Target

Target Organism Staphylococcus aureus ATCC2592

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli ATCC25922 (MIC 15 ug/ml), S. aureus ATCC2592 (MIC 3.7 uM), and C. albicans ATCC2002 (MIC 7.5 ug/ml).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 7.5 µg/mL

Target

Target Organism Candida albicans ATCC2002

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli ATCC25922 (MIC 15 ug/ml), S. aureus ATCC2592 (MIC 3.7 uM), and C. albicans ATCC2002 (MIC 7.5 ug/ml).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 15 µg/mL

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against E. coli ATCC25922 (MIC 15 ug/ml), S. aureus ATCC2592 (MIC 3.7 uM), and C. albicans ATCC2002 (MIC 7.5 ug/ml).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 3.7 µM

Target

Target Organism Staphylococcus aureus ATCC2592

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against E. coli ATCC25922 (MIC 15 ug/ml), S. aureus ATCC2592 (MIC 3.7 uM), and C. albicans ATCC2002 (MIC 7.5 ug/ml).

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 7.5 µg/mL

Target

Target Organism Candida albicans ATCC2002

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against E. coli ATCC25922 (MIC 15 ug/ml), S. aureus ATCC2592 (MIC 3.7 uM), and C. albicans ATCC2002 (MIC 7.5 ug/ml).

Evidence 10 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.16330062]Little hemolytic activity at 50 µg/ml against rabbit red blood cells

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Toxicon. 2006 Feb 47(2):249-53. Epub 2005 Dec 5. Peptides. 2006 Dec 27(12):3053-7. Epub 2006 Oct 13.