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Peptide record

TPDB05021

Brevinin-2DYd Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
33 amino acids
Basic Information
3D PDB MODEL
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TPDB05021
Brevinin-2DYd
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia CancerPPD 2.0 Antifp Antifungipept ToxinPred 3.0
standard
No
A 33-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GIFDVVKGVLKGVGKNVAGSLLEQLKCKLSGGC
Physicochemical Analysis
C147H254N40O42S2
RHMPTWY
G
3318.00
9.65
5
2
13
+3
4.99
0.491
117.88
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
3.77
6
Residue Composition
number
1
A
0
R
1
N
1
D
2
C
1
E
1
Q
7
G
0
H
1
I
5
L
5
K
0
M
1
F
0
P
2
S
0
T
0
W
0
Y
5
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 1 C: 2 E: 1 Q: 1 G: 7 H: 0 I: 1 L: 5 K: 5 M: 0 F: 1 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 5
Chemical Descriptors
33
C147H254N40O42S2
3318.00
9.65
+3
4.99
0.491
Free
L
Linear
Free
Anticancer
Rana dybowskii
Evidence Records 6 records
Evidence 1 Activity

Activity

IC50
IC50 = 2.975 µg/ml
Anticancer
2.975 µg/mL

Target

Lung Cancer
A-549
Lung

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2021

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

IC50
IC50 = 25.74 µg/ml
Anticancer
25.74 µg/mL

Target

Breast Cancer
MCF-7
Breast

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2021
Evidence 3 Activity

Activity

IC50
IC50 = 19.69 µg/ml
Anticancer
19.69 µg/mL

Target

Cervical Cancer
HeLa
Cervix

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2021
Evidence 4 Activity

Activity

IC50
IC50 = 8.05 µg/ml
Anticancer
8.05 µg/mL

Target

Colon Cancer
LoVo
Colon

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2021
Evidence 5 Activity

Activity

IC50
Toxicity
5.832 µM
Cytotoxic
IC50 | 5.832 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Prediction of Anticancer Peptides with High Efficacy and Low Toxicity by Hybrid Model Based on 3D Structure of Peptides. | Int J Mol Sci | 2021
Evidence 6 Activity

Activity

<10% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
<10% Hemolysis | 64 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Prediction of Anticancer Peptides with High Efficacy and Low Toxicity by Hybrid Model Based on 3D Structure of Peptides. | Int J Mol Sci | 2021