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Peptide record

TPDB05005

Antibacterial Anticancer Antifungal Antiparasitic Cell-penetrating Peptides Hemolysis Toxicity standard

12 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB05005

Activity

Antibacterial Anticancer Antifungal Antiparasitic Cell-penetrating Peptides Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia CancerPPD 2.0 Antifungipept CAFPdb CellPPD-MOD CPPsite3.0 PerseuCPP APD_complete PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 12-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

ILGTILGLLKGL

FASTA

>TPDB05005|Antibacterial;Anticancer;Antifungal;Antiparasitic;Cell-penetrating Peptides;Hemolysis;Toxicity|length=12
ILGTILGLLKGL

Formula C58H107N13O14

Absent Amino Acids ARNDCEQHMFPSWYV

Common Amino Acids L

Mass 1210.57

PI 10.10

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 7

Net Charge +1

Boman Index -2.26

Hydrophobicity 1.850

Aliphatic Index 227.50

Half Life

Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 2 L: 5 K: 1 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 0

Length

Formula

C58H107N13O14

Mass

1210.57

10.10

Net Charge

Boman Index

-2.26

Hydrophobicity

1.850

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 20-64 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against E. coli (MIC 20-64 uM), P. aeruginosa (MIC 1 uM), S. epidermidis (MIC 8 uM), B. subtilis (MIC 4 uM), and S. aure

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E. coli (MIC 20-64 uM), P. aeruginosa (MIC 1 uM), S. epidermidis (MIC 8 uM), B. subtilis (MIC 4 uM), and S. aureus (MIC 8-10 uM) (ref. see

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µM

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E. coli (MIC 20-64 uM), P. aeruginosa (MIC 1 uM), S. epidermidis (MIC 8 uM), B. subtilis (MIC 4 uM), and S. aureus (MIC 8-10 uM) (ref. see AP1640).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

tive against E. coli (MIC 20-64 uM), P. aeruginosa (MIC 1 uM), S. epidermidis (MIC 8 uM), B. subtilis (MIC 4 uM), and S. aureus (MIC 8-10 uM) (ref. see AP1640).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8-10 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

-64 uM), P. aeruginosa (MIC 1 uM), S. epidermidis (MIC 8 uM), B. subtilis (MIC 4 uM), and S. aureus (MIC 8-10 uM) (ref. see AP1640).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 20-64 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against E. coli (MIC 20-64 uM), P. aeruginosa (MIC 1 uM), S. epidermidis (MIC 8 uM), B. subtilis (MIC 4 uM), and S. aure

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli (MIC 20-64 uM), P. aeruginosa (MIC 1 uM), S. epidermidis (MIC 8 uM), B. subtilis (MIC 4 uM), and S. aureus (MIC 8-10 uM) (ref. see

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8 µM

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli (MIC 20-64 uM), P. aeruginosa (MIC 1 uM), S. epidermidis (MIC 8 uM), B. subtilis (MIC 4 uM), and S. aureus (MIC 8-10 uM) (ref. see AP1640).

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µM

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

tive against E. coli (MIC 20-64 uM), P. aeruginosa (MIC 1 uM), S. epidermidis (MIC 8 uM), B. subtilis (MIC 4 uM), and S. aureus (MIC 8-10 uM) (ref. see AP1640).

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8-10 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

-64 uM), P. aeruginosa (MIC 1 uM), S. epidermidis (MIC 8 uM), B. subtilis (MIC 4 uM), and S. aureus (MIC 8-10 uM) (ref. see AP1640).

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 20-64 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against E. coli (MIC 20-64 uM), P. aeruginosa (MIC 1 uM), S. epidermidis (MIC 8 uM), B. subtilis (MIC 4 uM), and S. aure

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against E. coli (MIC 20-64 uM), P. aeruginosa (MIC 1 uM), S. epidermidis (MIC 8 uM), B. subtilis (MIC 4 uM), and S. aureus (MIC 8-10 uM) (ref. see

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 8 µM

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against E. coli (MIC 20-64 uM), P. aeruginosa (MIC 1 uM), S. epidermidis (MIC 8 uM), B. subtilis (MIC 4 uM), and S. aureus (MIC 8-10 uM) (ref. see AP1640).

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 4 µM

Target

Target Organism B. subtilis

Source & Reference

Database Source DRAMP

Other

Evidence Text

tive against E. coli (MIC 20-64 uM), P. aeruginosa (MIC 1 uM), S. epidermidis (MIC 8 uM), B. subtilis (MIC 4 uM), and S. aureus (MIC 8-10 uM) (ref. see AP1640).

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 8-10 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source DRAMP

Other

Evidence Text

-64 uM), P. aeruginosa (MIC 1 uM), S. epidermidis (MIC 8 uM), B. subtilis (MIC 4 uM), and S. aureus (MIC 8-10 uM) (ref. see AP1640).

Evidence 16 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 80 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 80 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Protonectin (1-6): a novel chemotactic peptide from the venom of the social wasp Agelaia pallipes pallipes. | Toxicon | 2010

Evidence 17 Activity

Activity

Activity Endpoint ED50

Detail Source Activity Toxicity

Activity Measurement 80 µM

Toxicity Type Cytotoxic

Toxicity Raw

ED50 | 80 | µM | target cell: Rat mast cells

Target

Target Cell Rat mast cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Protonectin (1-6): a novel chemotactic peptide from the venom of the social wasp Agelaia pallipes pallipes. | Toxicon | 2010

Evidence 18 Activity

Activity

Activity Endpoint 70% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 64 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

70% Hemolysis | 64 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Antimicrobial activity and stability of protonectin with D-amino acid substitutions. | J Pept Sci | 2017

Evidence 19 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement >64 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | >64 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Antimicrobial and Anticancer Properties of Synthetic Peptides Derived from the Wasp Parachartergus fraternus. | Chembiochem | 2020

Evidence 20 Activity

Activity

Activity Endpoint 50% Cell death

Detail Source Activity Toxicity

Activity Measurement 18.3±1.2 µM

Toxicity Type Cytotoxic

Toxicity Raw

50% Cell death | 18.3±1.2 | µM | target cell: Human keratinocytes HaCat

Target

Target Cell Human keratinocytes HaCat

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Antimicrobial and Anticancer Properties of Synthetic Peptides Derived from the Wasp Parachartergus fraternus. | Chembiochem | 2020

Evidence 21 Activity

Activity

Activity Endpoint 50% Cell death

Detail Source Activity Toxicity

Activity Measurement 11.7±0.4 µM

Toxicity Type Cytotoxic

Toxicity Raw

50% Cell death | 11.7±0.4 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Target Cell Human embryonic kidney HEK293 cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Antimicrobial and Anticancer Properties of Synthetic Peptides Derived from the Wasp Parachartergus fraternus. | Chembiochem | 2020

Evidence 22 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 40 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 40 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Protonectin (1-6): a novel chemotactic peptide from the venom of the social wasp Agelaia pallipes pallipes. | Toxicon | 2010

Evidence 23 Activity

Activity

Activity Endpoint ED50

Detail Source Activity Toxicity

Activity Measurement 35 µM

Toxicity Type Cytotoxic

Toxicity Raw

ED50 | 35 | µM | target cell: Rat mast cells

Target

Target Cell Rat mast cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Protonectin (1-6): a novel chemotactic peptide from the venom of the social wasp Agelaia pallipes pallipes. | Toxicon | 2010

Evidence 24 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.15052574]Non-hemolytic activity against rat red blood cell

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Toxicon. 2004 Jul 44(1):67-74.##Rapid Commun Mass Spectrom. 2004 18(6):636-642.

Evidence 25 Hemolysis

Source & Reference

source APD_complete PD_Hemolysis

Database Source APD_complete PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation.