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Peptide record

TPDB04997

Antibacterial Anticancer Antidiabetic Antifungal Antiparasitic Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB04997
Antibacterial Anticancer Antidiabetic Antifungal Antiparasitic Toxicity
Anti-infective peptides Cardiometabolic peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia Antifungipept CAFPdb ToxinPred 3.0
standard
No
A 22-aa standard natural multi-activity (Antibacterial, Anticancer, Antidiabetic, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GMASKAGSVLGKVAKVALKAAL
Physicochemical Analysis
C92H168N26O25S1
RNDCEQHIFPTWY
A
2070.57
11.00
4
0
13
+4
1.53
0.832
120.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
6
A
0
R
0
N
0
D
0
C
0
E
0
Q
3
G
0
H
0
I
3
L
4
K
1
M
0
F
0
P
2
S
0
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 6 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 0 L: 3 K: 4 M: 1 F: 0 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 3
Chemical Descriptors
22
C92H168N26O25S1
2070.57
11.00
+4
1.53
0.832
Evidence Records 5 records
Evidence 1 Activity

Activity

MIC
Antibacterial
50 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against E. coli (25 uM) and S. aureus (MIC 50 uM). Beta-cells without cytotoxicity at concentrations up to 3 uM. The peptide can bind to LP
Evidence 2 Activity

Activity

MIC
Antifungal
50 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against E. coli (25 uM) and S. aureus (MIC 50 uM). Beta-cells without cytotoxicity at concentrations up to 3 uM. The peptide can bind to LP
Evidence 3 Activity

Activity

MIC
Antiparasitic
50 µM

Target

Staphylococcus aureus

Source & Reference

NA

Other

Active against E. coli (25 uM) and S. aureus (MIC 50 uM). Beta-cells without cytotoxicity at concentrations up to 3 uM. The peptide can bind to LP
Evidence 4 Activity

Activity

50% Hemolysis
Toxicity
>500 µM
Hemolytic Cytotoxic
50% Hemolysis | >500 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Host-defense peptides with therapeutic potential from skin secretions of frogs from the family pipidae. | Pharmaceuticals (Basel) | 2014
Evidence 5 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human oral fibroblasts

Target

Human oral fibroblasts

Source & Reference

NA
DBAASP
Antimicrobial and immunomodulatory properties of PGLa-AM1, CPF-AM1, and magainin-AM1: potent activity against oral pathogens. | Regul Pept | 2014