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Peptide record

TPDB04993

Antibacterial Anticancer Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB04993
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CancerPPD 2.0 ToxinPred 3.0
standard
No
A 29-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.
Sequence
GLPTCGETCFKGKCYTPGCSCSYPICKKD
Physicochemical Analysis
C131H205N33O41S6
ARNQHMWV
C
3090.63
8.01
4
2
5
+2
3.96
-0.317
26.90
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
3355
108.55
13
Residue Composition
number
0
A
0
R
0
N
1
D
6
C
1
E
0
Q
4
G
0
H
1
I
1
L
4
K
0
M
1
F
3
P
2
S
3
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 1 C: 6 E: 1 Q: 0 G: 4 H: 0 I: 1 L: 1 K: 4 M: 0 F: 1 P: 3 S: 2 T: 3 W: 0 Y: 2 V: 0
Chemical Descriptors
29
C131H205N33O41S6
3090.63
8.01
+2
3.96
-0.317
Evidence Records 3 records
Evidence 1 Activity

Activity

CC50
Toxicity
3.13±0.16 µM
Cytotoxic
CC50 | 3.13±0.16 | µM | target cell: Human foreskin fibroblasts (HFF)

Target

Human foreskin fibroblasts (HFF)

Source & Reference

NA
DBAASP
Lysine-rich Cyclotides: A New Subclass of Circular Knotted Proteins from Violaceae. | ACS Chem Biol | 2015
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
>64 µM
Hemolytic Cytotoxic
50% Hemolysis | >64 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Lysine-rich Cyclotides: A New Subclass of Circular Knotted Proteins from Violaceae. | ACS Chem Biol | 2015
Evidence 3 Activity

Activity

% Hemolysis
Toxicity
50 %
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: 50% Hemolysis>64µM | Cytotoxicity: HFF-1: CC50=3.13±0.16µM

Target

erythrocytes

Source & Reference

NA
DRAMP
ACS Chem Biol. 2015 Nov 20 10(11):2491-500.