Back to search

Peptide record

TPDB04991

Antibacterial Anticancer Hemolysis Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB04991
Antibacterial Anticancer Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia SATPdb HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Anticancer, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, SATPdb, and other sources, with an available 3D structural model.
Sequence
GWKDWFRKAKKVGKTVGGLALNHYL
Physicochemical Analysis
C136H210N38O31
CEQIMPS
K
2873.40
10.76
7
1
11
+5
0.90
-0.536
78.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
12490
434.68
3
Residue Composition
number
2
A
1
R
1
N
1
D
0
C
0
E
0
Q
4
G
1
H
0
I
3
L
5
K
0
M
1
F
0
P
0
S
1
T
2
W
1
Y
2
V
Amino Acid Distribution
A: 2 R: 1 N: 1 D: 1 C: 0 E: 0 Q: 0 G: 4 H: 1 I: 0 L: 3 K: 5 M: 0 F: 1 P: 0 S: 0 T: 1 W: 2 Y: 1 V: 2
Chemical Descriptors
25
C136H210N38O31
2873.40
10.76
+5
0.90
-0.536
Evidence Records 4 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>256 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >256 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents. | Dis Model Mech | 2011
Evidence 2 Activity

Activity

>10% Killing
Toxicity
5 µM
Cytotoxic
>10% Killing | 5 | µM | target cell: Zebrafish embryos

Target

Zebrafish embryos

Source & Reference

NA
DBAASP
The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents. | Dis Model Mech | 2011
Evidence 3 Activity

Activity

% Hemolysis
Toxicity
50 %
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: 50% Hemolysis>256 µg/ml | Cytotoxicity: Zebrafish embryos: >10% Killing=5 µg/ml (4, 28, 52hpf embryo)

Target

erythrocytes

Source & Reference

NA
DRAMP
Dis Model Mech. 2011 Sep 4(5):622-33.
Evidence 4 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis