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Peptide record

TPDB04985

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
33 amino acids
Basic Information
3D PDB MODEL
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TPDB04985
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb dbAMP 3.0 APD_complete APD_hemolytic PD_Hemolysis ToxinPred 3.0
standard
No
A 33-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GLWSKIKAAGKEAAKAAAKAAGKAALNAVSEAV
Physicochemical Analysis
C140H239N41O41
RDCQHMFPTY
A
3152.69
10.54
6
2
19
+4
5.34
0.191
92.42
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
174.45
3
Residue Composition
number
13
A
0
R
1
N
0
D
0
C
2
E
0
Q
3
G
0
H
1
I
2
L
6
K
0
M
0
F
0
P
2
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 13 R: 0 N: 1 D: 0 C: 0 E: 2 Q: 0 G: 3 H: 0 I: 1 L: 2 K: 6 M: 0 F: 0 P: 0 S: 2 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
33
C140H239N41O41
3152.69
10.54
+4
5.34
0.191
Evidence Records 14 records
Evidence 1 Activity

Activity

MIC
Antibacterial
>19 µM

Target

Enterococcus faecalis

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E.faecalis (MIC>19 uM), P. aeruginosa (MIC 2.4 uM), E. coli (MIC 0.6 uM), S. aureus (MIC 4.7 uM). Hemolysis > 32
Evidence 2 Activity

Activity

MIC
Antibacterial
2.4 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

Active against E.faecalis (MIC>19 uM), P. aeruginosa (MIC 2.4 uM), E. coli (MIC 0.6 uM), S. aureus (MIC 4.7 uM). Hemolysis > 32 uM. Also provided by Erik M
Evidence 3 Activity

Activity

MIC
Antibacterial
0.6 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Active against E.faecalis (MIC>19 uM), P. aeruginosa (MIC 2.4 uM), E. coli (MIC 0.6 uM), S. aureus (MIC 4.7 uM). Hemolysis > 32 uM. Also provided by Erik Martin.
Evidence 4 Activity

Activity

MIC
Antibacterial
4.7 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Active against E.faecalis (MIC>19 uM), P. aeruginosa (MIC 2.4 uM), E. coli (MIC 0.6 uM), S. aureus (MIC 4.7 uM). Hemolysis > 32 uM. Also provided by Erik Martin.
Evidence 5 Activity

Activity

MIC
Antifungal
>19 µM

Target

Enterococcus faecalis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E.faecalis (MIC>19 uM), P. aeruginosa (MIC 2.4 uM), E. coli (MIC 0.6 uM), S. aureus (MIC 4.7 uM). Hemolysis > 32
Evidence 6 Activity

Activity

MIC
Antifungal
2.4 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E.faecalis (MIC>19 uM), P. aeruginosa (MIC 2.4 uM), E. coli (MIC 0.6 uM), S. aureus (MIC 4.7 uM). Hemolysis > 32 uM. Also provided by Erik M
Evidence 7 Activity

Activity

MIC
Antifungal
0.6 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E.faecalis (MIC>19 uM), P. aeruginosa (MIC 2.4 uM), E. coli (MIC 0.6 uM), S. aureus (MIC 4.7 uM). Hemolysis > 32 uM. Also provided by Erik Martin.
Evidence 8 Activity

Activity

MIC
Antifungal
4.7 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E.faecalis (MIC>19 uM), P. aeruginosa (MIC 2.4 uM), E. coli (MIC 0.6 uM), S. aureus (MIC 4.7 uM). Hemolysis > 32 uM. Also provided by Erik Martin.
Evidence 9 Activity

Activity

MIC
Antiparasitic
>19 µM

Target

Enterococcus faecalis

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
Active against E.faecalis (MIC>19 uM), P. aeruginosa (MIC 2.4 uM), E. coli (MIC 0.6 uM), S. aureus (MIC 4.7 uM). Hemolysis > 32
Evidence 10 Activity

Activity

MIC
Antiparasitic
2.4 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against E.faecalis (MIC>19 uM), P. aeruginosa (MIC 2.4 uM), E. coli (MIC 0.6 uM), S. aureus (MIC 4.7 uM). Hemolysis > 32 uM. Also provided by Erik M
Evidence 11 Activity

Activity

MIC
Antiparasitic
0.6 µM

Target

Escherichia coli

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against E.faecalis (MIC>19 uM), P. aeruginosa (MIC 2.4 uM), E. coli (MIC 0.6 uM), S. aureus (MIC 4.7 uM). Hemolysis > 32 uM. Also provided by Erik Martin.
Evidence 12 Activity

Activity

MIC
Antiparasitic
4.7 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against E.faecalis (MIC>19 uM), P. aeruginosa (MIC 2.4 uM), E. coli (MIC 0.6 uM), S. aureus (MIC 4.7 uM). Hemolysis > 32 uM. Also provided by Erik Martin.
Evidence 13 Activity

Activity

100% Hemolysis
Toxicity
>32.0 µM
Hemolytic Cytotoxic
100% Hemolysis | >32.0 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial peptides from the Brazilian frog Phyllomedusa distincta. | Peptides | 1999
Evidence 14 Hemolysis

Source & Reference

APD_complete APD_hemolytic PD_Hemolysis
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.