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Peptide record

TPDB04984

Antibacterial Antifungal Hemolysis Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB04984
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb DRAMP dbAMP APD_complete PD_Hemolysis ToxinPred 3.0
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
FIGMIPGLIGGLISAIK
Physicochemical Analysis
C81H138N18O19S1
RNDCEQHTWYV
I
1700.16
10.10
1
0
10
+1
-2.59
1.688
166.47
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
4
G
0
H
5
I
2
L
1
K
1
M
1
F
1
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 0 I: 5 L: 2 K: 1 M: 1 F: 1 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
17
C81H138N18O19S1
1700.16
10.10
+1
-2.59
1.688
Evidence Records 18 records
Evidence 1 Activity

Activity

MIC
Antibacterial
5-10 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
DRAMP antibacterial activity supported by MIC records against bacterial target organisms. dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S. aureus (MIC 5-10 uM), B. subtilis (MIC 2.5-5 uM), C. albicans SC5314 (MIC 25 uM), C. tropicalis ATCC 750 (MIC
Evidence 2 Activity

Activity

MIC
Antibacterial
2.5-5 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

Active against S. aureus (MIC 5-10 uM), B. subtilis (MIC 2.5-5 uM), C. albicans SC5314 (MIC 25 uM), C. tropicalis ATCC 750 (MIC 12.5 uM), C. parapsilosis AT
Evidence 3 Activity

Activity

MIC
Antibacterial
25 µM

Target

Candida albicans SC5314

Source & Reference

dbAMP DRAMP

Other

Active against S. aureus (MIC 5-10 uM), B. subtilis (MIC 2.5-5 uM), C. albicans SC5314 (MIC 25 uM), C. tropicalis ATCC 750 (MIC 12.5 uM), C. parapsilosis ATCC 22019 (MIC 100 uM), C. neofor
Evidence 4 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

C. tropicalis ATCC 750

Source & Reference

dbAMP DRAMP

Other

inst S. aureus (MIC 5-10 uM), B. subtilis (MIC 2.5-5 uM), C. albicans SC5314 (MIC 25 uM), C. tropicalis ATCC 750 (MIC 12.5 uM), C. parapsilosis ATCC 22019 (MIC 100 uM), C. neoformans H99 serotype A (MIC 100 uM), and
Evidence 5 Activity

Activity

MIC
Antibacterial
100 µM

Target

C. parapsilosis ATCC 22019

Source & Reference

dbAMP DRAMP

Other

lis (MIC 2.5-5 uM), C. albicans SC5314 (MIC 25 uM), C. tropicalis ATCC 750 (MIC 12.5 uM), C. parapsilosis ATCC 22019 (MIC 100 uM), C. neoformans H99 serotype A (MIC 100 uM), and C. neoformans B3501 serotype D (MIC 25 uM
Evidence 6 Activity

Activity

MIC
Antibacterial
100 µM

Target

C. neoformans H99 serotype A

Source & Reference

dbAMP DRAMP

Other

IC 25 uM), C. tropicalis ATCC 750 (MIC 12.5 uM), C. parapsilosis ATCC 22019 (MIC 100 uM), C. neoformans H99 serotype A (MIC 100 uM), and C. neoformans B3501 serotype D (MIC 25 uM). inactive: E.coli (MIC>200 uM). updated 7
Evidence 7 Activity

Activity

MIC
Antibacterial
25 µM

Target

C. neoformans B3501 serotype D

Source & Reference

dbAMP DRAMP

Other

, C. parapsilosis ATCC 22019 (MIC 100 uM), C. neoformans H99 serotype A (MIC 100 uM), and C. neoformans B3501 serotype D (MIC 25 uM). inactive: E.coli (MIC>200 uM). updated 7/2021
Evidence 8 Activity

Activity

MIC
Antibacterial
>200 µM

Target

E.coli

Source & Reference

dbAMP DRAMP

Other

ns H99 serotype A (MIC 100 uM), and C. neoformans B3501 serotype D (MIC 25 uM). inactive: E.coli (MIC>200 uM). updated 7/2021
Evidence 9 Activity

Activity

MIC
Antifungal
5-10 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
DRAMP antifungal activity supported by activity records against fungal target organisms. dbAMP classified under the Anti-fungal function class.
Active against S. aureus (MIC 5-10 uM), B. subtilis (MIC 2.5-5 uM), C. albicans SC5314 (MIC 25 uM), C. tropicalis ATCC 750 (MIC
Evidence 10 Activity

Activity

MIC
Antifungal
2.5-5 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against S. aureus (MIC 5-10 uM), B. subtilis (MIC 2.5-5 uM), C. albicans SC5314 (MIC 25 uM), C. tropicalis ATCC 750 (MIC 12.5 uM), C. parapsilosis AT
Evidence 11 Activity

Activity

MIC
Antifungal
25 µM

Target

Candida albicans SC5314

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against S. aureus (MIC 5-10 uM), B. subtilis (MIC 2.5-5 uM), C. albicans SC5314 (MIC 25 uM), C. tropicalis ATCC 750 (MIC 12.5 uM), C. parapsilosis ATCC 22019 (MIC 100 uM), C. neofor
Evidence 12 Activity

Activity

MIC
Antifungal
12.5 µM

Target

C. tropicalis ATCC 750

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

inst S. aureus (MIC 5-10 uM), B. subtilis (MIC 2.5-5 uM), C. albicans SC5314 (MIC 25 uM), C. tropicalis ATCC 750 (MIC 12.5 uM), C. parapsilosis ATCC 22019 (MIC 100 uM), C. neoformans H99 serotype A (MIC 100 uM), and
Evidence 13 Activity

Activity

MIC
Antifungal
100 µM

Target

C. parapsilosis ATCC 22019

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

lis (MIC 2.5-5 uM), C. albicans SC5314 (MIC 25 uM), C. tropicalis ATCC 750 (MIC 12.5 uM), C. parapsilosis ATCC 22019 (MIC 100 uM), C. neoformans H99 serotype A (MIC 100 uM), and C. neoformans B3501 serotype D (MIC 25 uM
Evidence 14 Activity

Activity

MIC
Antifungal
100 µM

Target

C. neoformans H99 serotype A

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

IC 25 uM), C. tropicalis ATCC 750 (MIC 12.5 uM), C. parapsilosis ATCC 22019 (MIC 100 uM), C. neoformans H99 serotype A (MIC 100 uM), and C. neoformans B3501 serotype D (MIC 25 uM). inactive: E.coli (MIC>200 uM). updated 7
Evidence 15 Activity

Activity

MIC
Antifungal
25 µM

Target

C. neoformans B3501 serotype D

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

, C. parapsilosis ATCC 22019 (MIC 100 uM), C. neoformans H99 serotype A (MIC 100 uM), and C. neoformans B3501 serotype D (MIC 25 uM). inactive: E.coli (MIC>200 uM). updated 7/2021
Evidence 16 Activity

Activity

MIC
Antifungal
>200 µM

Target

E.coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ns H99 serotype A (MIC 100 uM), and C. neoformans B3501 serotype D (MIC 25 uM). inactive: E.coli (MIC>200 uM). updated 7/2021
Evidence 17 Activity

Activity

50% Hemolysis
Toxicity
>30 µM
Hemolytic Cytotoxic
50% Hemolysis | >30 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Complete de novo sequencing of antimicrobial peptides in the venom of the scorpion Isometrus maculatus. | Toxicon | 2017
Evidence 18 Hemolysis

Source & Reference

APD_complete PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.