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Peptide record

TPDB04976

DRS B3 Antibacterial Anticancer Antifungal Antiparasitic standard

28 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB04976

Peptide_Name

DRS B3

Activity

Antibacterial Anticancer Antifungal Antiparasitic

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF Antifungipept

Sequence_Type

standard

Has_Modification No

Description A 28-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

ALWKNMLKGIGKLAGQAALGAVKTLVGA

FASTA

>TPDB04976|Antibacterial;Anticancer;Antifungal;Antiparasitic|length=28
ALWKNMLKGIGKLAGQAALGAVKTLVGA

Formula C127H219N35O32S1

Absent Amino Acids RDCEHFPSY

Common Amino Acids A

Mass 2780.41

PI 11.00

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 16

Net Charge +4

Boman Index -0.92

Hydrophobicity 0.657

Aliphatic Index 125.71

Half Life

Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 197.81

Polar Residues 3

number

Amino Acid Distribution

A: 6 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 1 G: 5 H: 0 I: 1 L: 5 K: 4 M: 1 F: 0 P: 0 S: 0 T: 1 W: 1 Y: 0 V: 2

Length

Formula

C127H219N35O32S1

Mass

2780.41

11.00

Net Charge

Boman Index

-0.92

Hydrophobicity

0.657

C_terminal_Modification

Free

Chirality

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Antimicrobial

Origin

Dermaseptins B

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.3 µM

Target

Target Organism Staphylococcus aureus ATCC 25923

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Strongly active against S. aureus ATCC 25923 (MIC 1.3 uM), P. aeruginosa CIP A22 (MIC 2.3 uM), P. aeruginosa ATCC 27853 (MIC 5.0 uM) and E. coli AT

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2.3 µM

Target

Target Organism Pseudomonas aeruginosa CIP A22

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Strongly active against S. aureus ATCC 25923 (MIC 1.3 uM), P. aeruginosa CIP A22 (MIC 2.3 uM), P. aeruginosa ATCC 27853 (MIC 5.0 uM) and E. coli ATCC 25922 (MIC 2.6 uM). Updated 4/201

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 5.0 µM

Target

Target Organism Pseudomonas aeruginosa ATCC 27853

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

gly active against S. aureus ATCC 25923 (MIC 1.3 uM), P. aeruginosa CIP A22 (MIC 2.3 uM), P. aeruginosa ATCC 27853 (MIC 5.0 uM) and E. coli ATCC 25922 (MIC 2.6 uM). Updated 4/2019, seq 5/2020 7/2021

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2.6 µM

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

IC 1.3 uM), P. aeruginosa CIP A22 (MIC 2.3 uM), P. aeruginosa ATCC 27853 (MIC 5.0 uM) and E. coli ATCC 25922 (MIC 2.6 uM). Updated 4/2019, seq 5/2020 7/2021

Evidence 5 Activity

Activity

Activity Endpoint Cytotoxicity

Activity Raw

Cytotoxicity =12 µM

Detail Source Activity Anticancer

Target

Cancer Type Breast Cancer

Cell Line MCF-7

Tissue Affected Breast

Assay & Model

Assay Thymidine Incorporation assay

Testing Time 6-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 1998

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.3 µM

Target

Target Organism Staphylococcus aureus ATCC 25923

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Strongly active against S. aureus ATCC 25923 (MIC 1.3 uM), P. aeruginosa CIP A22 (MIC 2.3 uM), P. aeruginosa ATCC 27853 (MIC 5.0 uM) and E. coli AT

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2.3 µM

Target

Target Organism Pseudomonas aeruginosa CIP A22

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Strongly active against S. aureus ATCC 25923 (MIC 1.3 uM), P. aeruginosa CIP A22 (MIC 2.3 uM), P. aeruginosa ATCC 27853 (MIC 5.0 uM) and E. coli ATCC 25922 (MIC 2.6 uM). Updated 4/201

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 5.0 µM

Target

Target Organism Pseudomonas aeruginosa ATCC 27853

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

gly active against S. aureus ATCC 25923 (MIC 1.3 uM), P. aeruginosa CIP A22 (MIC 2.3 uM), P. aeruginosa ATCC 27853 (MIC 5.0 uM) and E. coli ATCC 25922 (MIC 2.6 uM). Updated 4/2019, seq 5/2020 7/2021

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2.6 µM

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

IC 1.3 uM), P. aeruginosa CIP A22 (MIC 2.3 uM), P. aeruginosa ATCC 27853 (MIC 5.0 uM) and E. coli ATCC 25922 (MIC 2.6 uM). Updated 4/2019, seq 5/2020 7/2021

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.3 µM

Target

Target Organism Staphylococcus aureus ATCC 25923

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Strongly active against S. aureus ATCC 25923 (MIC 1.3 uM), P. aeruginosa CIP A22 (MIC 2.3 uM), P. aeruginosa ATCC 27853 (MIC 5.0 uM) and E. coli AT

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 2.3 µM

Target

Target Organism Pseudomonas aeruginosa CIP A22

Source & Reference

Database Source DRAMP

Other

Evidence Text

Strongly active against S. aureus ATCC 25923 (MIC 1.3 uM), P. aeruginosa CIP A22 (MIC 2.3 uM), P. aeruginosa ATCC 27853 (MIC 5.0 uM) and E. coli ATCC 25922 (MIC 2.6 uM). Updated 4/201

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 5.0 µM

Target

Target Organism Pseudomonas aeruginosa ATCC 27853

Source & Reference

Database Source DRAMP

Other

Evidence Text

gly active against S. aureus ATCC 25923 (MIC 1.3 uM), P. aeruginosa CIP A22 (MIC 2.3 uM), P. aeruginosa ATCC 27853 (MIC 5.0 uM) and E. coli ATCC 25922 (MIC 2.6 uM). Updated 4/2019, seq 5/2020 7/2021

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 2.6 µM

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source DRAMP

Other

Evidence Text

IC 1.3 uM), P. aeruginosa CIP A22 (MIC 2.3 uM), P. aeruginosa ATCC 27853 (MIC 5.0 uM) and E. coli ATCC 25922 (MIC 2.6 uM). Updated 4/2019, seq 5/2020 7/2021