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Peptide record

TPDB04971

Adrenocorticotropic Corticotropin Antibacterial Blood-Brain Barrier Neuropeptide standard
39 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB04971
Adrenocorticotropic Corticotropin
Antibacterial Blood-Brain Barrier Neuropeptide
Anti-infective peptides Delivery and barrier-penetrating peptides Neuroactive peptides
AntiBP3 Peptipedia BBPpredict
standard
No
A 39-aa standard natural multi-activity (Antibacterial, Blood-Brain Barrier, and Neuropeptide) peptide sequence curated from AntiBP3, Peptipedia, and BBPpredict, with an available 3D structural model.
Sequence
SYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEF
Physicochemical Analysis
C207H308N56O58S1
CQIT
E
4541.12
9.41
8
6
14
+1
13.11
-0.979
40.00
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
8480
186.74
6
Residue Composition
number
3
A
3
R
1
N
1
D
0
C
5
E
0
Q
3
G
1
H
0
I
1
L
4
K
1
M
3
F
4
P
3
S
0
T
1
W
2
Y
3
V
Amino Acid Distribution
A: 3 R: 3 N: 1 D: 1 C: 0 E: 5 Q: 0 G: 3 H: 1 I: 0 L: 1 K: 4 M: 1 F: 3 P: 4 S: 3 T: 0 W: 1 Y: 2 V: 3
Chemical Descriptors
39
C207H308N56O58S1
4541.12
9.41
+1
13.11
-0.979
Linear
Similarity
Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe
CC(C)CC(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C2CCCN2C(=O)C (CC3=CC=CC=C3)NC(=O)C(C)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C(CO)NC(=O)C (CCC(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)CNC(=O)C(CC(= O)N)NC(=O)C4CCCN4C(=O)C(CC5=CC=C(C=C5)O)NC(=O)C(C(C)C)NC(=O)C(CCCCN)NC(= O)C(C(C)C)NC(=O)C6CCCN6C(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C (CCCCN)NC(=O)C(CCCCN)NC(=O)CNC(=O)C(C(C)C)NC(=O)C7CCCN7C(=O)C(CCCCN)NC(= O)CNC(=O)C(CC8=CNC9=CC=CC=C98)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC1=CC=CC=C1)NC (=O)C(CC1=CN=CN1)NC(=O)C(CCC(=O)O)NC(=O)C(CCSC)NC(=O)C(CO)NC(=O)C(CC1= CC=C(C=C1)O)NC(=O)C(CO)N
Evidence Records 8 records
Evidence 1 Activity

Activity

MIC
Antibacterial
50 µM

Target

Pseudomonas aeruginosa PA14

Source & Reference

NA

Other

Active against E-coli ATCC11775 (MIC >50 uM), P-aeruginosa PA01 (MIC >50 uM), P. aeruginosa PA14 (MIC 50 uM), S. aureus ATCC12600 (MIC 50 uM), K-pneumoniae ATCC133883 (MIC >50 uM), A-baumannii ATCC1
Evidence 2 Activity

Activity

MIC
Antibacterial
50 µM

Target

Staphylococcus aureus ATCC12600

Source & Reference

NA

Other

i ATCC11775 (MIC >50 uM), P-aeruginosa PA01 (MIC >50 uM), P. aeruginosa PA14 (MIC 50 uM), S. aureus ATCC12600 (MIC 50 uM), K-pneumoniae ATCC133883 (MIC >50 uM), A-baumannii ATCC19606 (MIC >50 uM), A-muciniphila
Evidence 3 Activity

Activity

Blood-Brain Barrier

Assay & Model

Origin/Source

Source & Reference

NA
B3Pdb

Other

human
Evidence 4 Activity

Activity

Neuropeptide

Source & Reference

NA
NeuroPepV2

Other

Balaenoptera borealis
POMC
Evidence 5 Activity

Activity

Neuropeptide

Source & Reference

NA
NeuroPepV2

Other

Balaenoptera physalus
POMC
Evidence 6 Activity

Activity

Neuropeptide

Target

Adrenocorticotropic hormone receptor Melanocortin receptor 3 Melanocortin receptor 4 Melanocortin receptor 5 Melanocyte-stimulating hormone receptor
Homo sapiens Homo sapiens Homo sapiens Homo sapiens Homo sapiens

Source & Reference

NA
NeuroPepV2

Other

Homo sapiens
POMC
297 323 332 325 317
NP08981 NP08981 NP09084 NP09109 NP09136 NP09173 NP08981 NP09084 NP09109 NP09136 NP09173 NP08981 NP09084 NP09109 NP09136 NP09173 NP08981 NP09084 NP09109 NP09136 NP09173 NP09034 NP09035
Evidence 7 Activity

Activity

Neuropeptide

Target

Melanocyte-stimulating hormone receptor
Macaca nemestrina

Source & Reference

NA
NeuroPepV2

Other

Macaca nemestrina
POMC
317
NP09138 NP08985 NP09088 NP09113
Evidence 8 Activity

Activity

Neuropeptide

Source & Reference

NA
NeuroPepV2

Other

Neovison vison
POMC
Additional Detail Fields 3 fields
POMC
297 323 332 325 317
NP08981 NP09084 NP09109 NP09136 NP09173 NP09034 NP09035 NP09138 NP08985 NP09088 NP09113