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Peptide record

TPDB04967

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB04967
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF pep-lab Antifungipept AI4AVP dbAMP 3.0 DRAVP 2.0 ToxinPred 3.0
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GLFSVLGAVAKHVLPHVVPVIAEKL
Physicochemical Analysis
C124H205N31O29
RNDCQMTWY
V
2594.18
9.88
4
1
15
+1
3.20
1.224
159.60
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
3
A
0
R
0
N
0
D
0
C
1
E
0
Q
2
G
2
H
1
I
4
L
2
K
0
M
1
F
2
P
1
S
0
T
0
W
0
Y
6
V
Amino Acid Distribution
A: 3 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 2 H: 2 I: 1 L: 4 K: 2 M: 0 F: 1 P: 2 S: 1 T: 0 W: 0 Y: 0 V: 6
Chemical Descriptors
25
C124H205N31O29
2594.18
9.88
+1
3.20
1.224
Evidence Records 38 records
Evidence 1 Activity

Activity

MIC
Antibacterial
100 µg/mL

Target

B. cereus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Activity against B. cereus (MIC 100 ug/ml), E.coli (MIC> 100 ug/ml), L. lactis (MIC 3 uM), L. innocua (MIC 50 ug/ml), M. luteus (MIC
Evidence 2 Activity

Activity

MIC
Antibacterial
3 µM

Target

L. lactis

Source & Reference

dbAMP DRAMP

Other

Activity against B. cereus (MIC 100 ug/ml), E.coli (MIC> 100 ug/ml), L. lactis (MIC 3 uM), L. innocua (MIC 50 ug/ml), M. luteus (MIC 25 ug/ml), S. aureus ATCC 25923 or 29213 (MIC
Evidence 3 Activity

Activity

MIC
Antibacterial
50 µg/mL

Target

L. innocua

Source & Reference

dbAMP DRAMP

Other

ctivity against B. cereus (MIC 100 ug/ml), E.coli (MIC> 100 ug/ml), L. lactis (MIC 3 uM), L. innocua (MIC 50 ug/ml), M. luteus (MIC 25 ug/ml), S. aureus ATCC 25923 or 29213 (MIC 6-12.5 ug/ml, S. epidermidi
Evidence 4 Activity

Activity

MIC
Antibacterial
25 µg/mL

Target

M. luteus

Source & Reference

dbAMP DRAMP

Other

MIC 100 ug/ml), E.coli (MIC> 100 ug/ml), L. lactis (MIC 3 uM), L. innocua (MIC 50 ug/ml), M. luteus (MIC 25 ug/ml), S. aureus ATCC 25923 or 29213 (MIC 6-12.5 ug/ml, S. epidermidis (MIC 12.5 ug/ml), S. ube
Evidence 5 Activity

Activity

MIC
Antibacterial
12.5 µg/mL

Target

Staphylococcus epidermidis

Source & Reference

dbAMP DRAMP

Other

MIC 50 ug/ml), M. luteus (MIC 25 ug/ml), S. aureus ATCC 25923 or 29213 (MIC 6-12.5 ug/ml, S. epidermidis (MIC 12.5 ug/ml), S. uberis (MIC 25 ug/ml), E.clocae (MIC >100 ug/ml), P. multocida (MIC 25 ug/ml), and P.
Evidence 6 Activity

Activity

MIC
Antibacterial
25 µg/mL

Target

S. uberis

Source & Reference

dbAMP DRAMP

Other

ug/ml), S. aureus ATCC 25923 or 29213 (MIC 6-12.5 ug/ml, S. epidermidis (MIC 12.5 ug/ml), S. uberis (MIC 25 ug/ml), E.clocae (MIC >100 ug/ml), P. multocida (MIC 25 ug/ml), and P. haemolytica (MIC 50 ug/ml
Evidence 7 Activity

Activity

MIC
Antibacterial
>100 µg/mL

Target

E.clocae

Source & Reference

dbAMP DRAMP

Other

23 or 29213 (MIC 6-12.5 ug/ml, S. epidermidis (MIC 12.5 ug/ml), S. uberis (MIC 25 ug/ml), E.clocae (MIC >100 ug/ml), P. multocida (MIC 25 ug/ml), and P. haemolytica (MIC 50 ug/ml) (same ref as AP2008). It
Evidence 8 Activity

Activity

MIC
Antibacterial
25 µg/mL

Target

P. multocida

Source & Reference

dbAMP DRAMP

Other

ml, S. epidermidis (MIC 12.5 ug/ml), S. uberis (MIC 25 ug/ml), E.clocae (MIC >100 ug/ml), P. multocida (MIC 25 ug/ml), and P. haemolytica (MIC 50 ug/ml) (same ref as AP2008). It contains two amphipathic heli
Evidence 9 Activity

Activity

MIC
Antibacterial
50 µg/mL

Target

P. haemolytica

Source & Reference

dbAMP DRAMP

Other

l), S. uberis (MIC 25 ug/ml), E.clocae (MIC >100 ug/ml), P. multocida (MIC 25 ug/ml), and P. haemolytica (MIC 50 ug/ml) (same ref as AP2008). It contains two amphipathic helices separated by a region of less-d
Evidence 10 Activity

Activity

MIC
Antifungal
100 µg/mL

Target

B. cereus

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Activity against B. cereus (MIC 100 ug/ml), E.coli (MIC> 100 ug/ml), L. lactis (MIC 3 uM), L. innocua (MIC 50 ug/ml), M. luteus (MIC
Evidence 11 Activity

Activity

MIC
Antifungal
3 µM

Target

L. lactis

Source & Reference

dbAMP DRAMP Antifungipept

Other

Activity against B. cereus (MIC 100 ug/ml), E.coli (MIC> 100 ug/ml), L. lactis (MIC 3 uM), L. innocua (MIC 50 ug/ml), M. luteus (MIC 25 ug/ml), S. aureus ATCC 25923 or 29213 (MIC
Evidence 12 Activity

Activity

MIC
Antifungal
50 µg/mL

Target

L. innocua

Source & Reference

dbAMP DRAMP Antifungipept

Other

ctivity against B. cereus (MIC 100 ug/ml), E.coli (MIC> 100 ug/ml), L. lactis (MIC 3 uM), L. innocua (MIC 50 ug/ml), M. luteus (MIC 25 ug/ml), S. aureus ATCC 25923 or 29213 (MIC 6-12.5 ug/ml, S. epidermidi
Evidence 13 Activity

Activity

MIC
Antifungal
25 µg/mL

Target

M. luteus

Source & Reference

dbAMP DRAMP Antifungipept

Other

MIC 100 ug/ml), E.coli (MIC> 100 ug/ml), L. lactis (MIC 3 uM), L. innocua (MIC 50 ug/ml), M. luteus (MIC 25 ug/ml), S. aureus ATCC 25923 or 29213 (MIC 6-12.5 ug/ml, S. epidermidis (MIC 12.5 ug/ml), S. ube
Evidence 14 Activity

Activity

MIC
Antifungal
12.5 µg/mL

Target

Staphylococcus epidermidis

Source & Reference

dbAMP DRAMP Antifungipept

Other

MIC 50 ug/ml), M. luteus (MIC 25 ug/ml), S. aureus ATCC 25923 or 29213 (MIC 6-12.5 ug/ml, S. epidermidis (MIC 12.5 ug/ml), S. uberis (MIC 25 ug/ml), E.clocae (MIC >100 ug/ml), P. multocida (MIC 25 ug/ml), and P.
Evidence 15 Activity

Activity

MIC
Antifungal
25 µg/mL

Target

S. uberis

Source & Reference

dbAMP DRAMP Antifungipept

Other

ug/ml), S. aureus ATCC 25923 or 29213 (MIC 6-12.5 ug/ml, S. epidermidis (MIC 12.5 ug/ml), S. uberis (MIC 25 ug/ml), E.clocae (MIC >100 ug/ml), P. multocida (MIC 25 ug/ml), and P. haemolytica (MIC 50 ug/ml
Evidence 16 Activity

Activity

MIC
Antifungal
>100 µg/mL

Target

E.clocae

Source & Reference

dbAMP DRAMP Antifungipept

Other

23 or 29213 (MIC 6-12.5 ug/ml, S. epidermidis (MIC 12.5 ug/ml), S. uberis (MIC 25 ug/ml), E.clocae (MIC >100 ug/ml), P. multocida (MIC 25 ug/ml), and P. haemolytica (MIC 50 ug/ml) (same ref as AP2008). It
Evidence 17 Activity

Activity

MIC
Antifungal
25 µg/mL

Target

P. multocida

Source & Reference

dbAMP DRAMP Antifungipept

Other

ml, S. epidermidis (MIC 12.5 ug/ml), S. uberis (MIC 25 ug/ml), E.clocae (MIC >100 ug/ml), P. multocida (MIC 25 ug/ml), and P. haemolytica (MIC 50 ug/ml) (same ref as AP2008). It contains two amphipathic heli
Evidence 18 Activity

Activity

MIC
Antifungal
50 µg/mL

Target

P. haemolytica

Source & Reference

dbAMP DRAMP Antifungipept

Other

l), S. uberis (MIC 25 ug/ml), E.clocae (MIC >100 ug/ml), P. multocida (MIC 25 ug/ml), and P. haemolytica (MIC 50 ug/ml) (same ref as AP2008). It contains two amphipathic helices separated by a region of less-d
Evidence 19 Activity

Activity

MIC
Antiparasitic
100 µg/mL

Target

B. cereus

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
Activity against B. cereus (MIC 100 ug/ml), E.coli (MIC> 100 ug/ml), L. lactis (MIC 3 uM), L. innocua (MIC 50 ug/ml), M. luteus (MIC
Evidence 20 Activity

Activity

MIC
Antiparasitic
3 µM

Target

L. lactis

Source & Reference

dbAMP 3.0 DRAMP

Other

Activity against B. cereus (MIC 100 ug/ml), E.coli (MIC> 100 ug/ml), L. lactis (MIC 3 uM), L. innocua (MIC 50 ug/ml), M. luteus (MIC 25 ug/ml), S. aureus ATCC 25923 or 29213 (MIC
Evidence 21 Activity

Activity

MIC
Antiparasitic
50 µg/mL

Target

L. innocua

Source & Reference

dbAMP 3.0 DRAMP

Other

ctivity against B. cereus (MIC 100 ug/ml), E.coli (MIC> 100 ug/ml), L. lactis (MIC 3 uM), L. innocua (MIC 50 ug/ml), M. luteus (MIC 25 ug/ml), S. aureus ATCC 25923 or 29213 (MIC 6-12.5 ug/ml, S. epidermidi
Evidence 22 Activity

Activity

MIC
Antiparasitic
25 µg/mL

Target

M. luteus

Source & Reference

dbAMP 3.0 DRAMP

Other

MIC 100 ug/ml), E.coli (MIC> 100 ug/ml), L. lactis (MIC 3 uM), L. innocua (MIC 50 ug/ml), M. luteus (MIC 25 ug/ml), S. aureus ATCC 25923 or 29213 (MIC 6-12.5 ug/ml, S. epidermidis (MIC 12.5 ug/ml), S. ube
Evidence 23 Activity

Activity

MIC
Antiparasitic
12.5 µg/mL

Target

Staphylococcus epidermidis

Source & Reference

dbAMP 3.0 DRAMP

Other

MIC 50 ug/ml), M. luteus (MIC 25 ug/ml), S. aureus ATCC 25923 or 29213 (MIC 6-12.5 ug/ml, S. epidermidis (MIC 12.5 ug/ml), S. uberis (MIC 25 ug/ml), E.clocae (MIC >100 ug/ml), P. multocida (MIC 25 ug/ml), and P.
Evidence 24 Activity

Activity

MIC
Antiparasitic
25 µg/mL

Target

S. uberis

Source & Reference

dbAMP 3.0 DRAMP

Other

ug/ml), S. aureus ATCC 25923 or 29213 (MIC 6-12.5 ug/ml, S. epidermidis (MIC 12.5 ug/ml), S. uberis (MIC 25 ug/ml), E.clocae (MIC >100 ug/ml), P. multocida (MIC 25 ug/ml), and P. haemolytica (MIC 50 ug/ml
Evidence 25 Activity

Activity

MIC
Antiparasitic
>100 µg/mL

Target

E.clocae

Source & Reference

dbAMP 3.0 DRAMP

Other

23 or 29213 (MIC 6-12.5 ug/ml, S. epidermidis (MIC 12.5 ug/ml), S. uberis (MIC 25 ug/ml), E.clocae (MIC >100 ug/ml), P. multocida (MIC 25 ug/ml), and P. haemolytica (MIC 50 ug/ml) (same ref as AP2008). It
Evidence 26 Activity

Activity

MIC
Antiparasitic
25 µg/mL

Target

P. multocida

Source & Reference

dbAMP 3.0 DRAMP

Other

ml, S. epidermidis (MIC 12.5 ug/ml), S. uberis (MIC 25 ug/ml), E.clocae (MIC >100 ug/ml), P. multocida (MIC 25 ug/ml), and P. haemolytica (MIC 50 ug/ml) (same ref as AP2008). It contains two amphipathic heli
Evidence 27 Activity

Activity

MIC
Antiparasitic
50 µg/mL

Target

P. haemolytica

Source & Reference

dbAMP 3.0 DRAMP

Other

l), S. uberis (MIC 25 ug/ml), E.clocae (MIC >100 ug/ml), P. multocida (MIC 25 ug/ml), and P. haemolytica (MIC 50 ug/ml) (same ref as AP2008). It contains two amphipathic helices separated by a region of less-d
Evidence 28 Activity

Activity

MIC
Antiviral
100 µg/mL

Target

B. cereus

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.
Activity against B. cereus (MIC 100 ug/ml), E.coli (MIC> 100 ug/ml), L. lactis (MIC 3 uM), L. innocua (MIC 50 ug/ml), M. luteus (MIC
Evidence 29 Activity

Activity

MIC
Antiviral
3 µM

Target

L. lactis

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Activity against B. cereus (MIC 100 ug/ml), E.coli (MIC> 100 ug/ml), L. lactis (MIC 3 uM), L. innocua (MIC 50 ug/ml), M. luteus (MIC 25 ug/ml), S. aureus ATCC 25923 or 29213 (MIC
Evidence 30 Activity

Activity

MIC
Antiviral
50 µg/mL

Target

L. innocua

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

ctivity against B. cereus (MIC 100 ug/ml), E.coli (MIC> 100 ug/ml), L. lactis (MIC 3 uM), L. innocua (MIC 50 ug/ml), M. luteus (MIC 25 ug/ml), S. aureus ATCC 25923 or 29213 (MIC 6-12.5 ug/ml, S. epidermidi
Evidence 31 Activity

Activity

MIC
Antiviral
25 µg/mL

Target

M. luteus

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

MIC 100 ug/ml), E.coli (MIC> 100 ug/ml), L. lactis (MIC 3 uM), L. innocua (MIC 50 ug/ml), M. luteus (MIC 25 ug/ml), S. aureus ATCC 25923 or 29213 (MIC 6-12.5 ug/ml, S. epidermidis (MIC 12.5 ug/ml), S. ube
Evidence 32 Activity

Activity

MIC
Antiviral
12.5 µg/mL

Target

Staphylococcus epidermidis

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

MIC 50 ug/ml), M. luteus (MIC 25 ug/ml), S. aureus ATCC 25923 or 29213 (MIC 6-12.5 ug/ml, S. epidermidis (MIC 12.5 ug/ml), S. uberis (MIC 25 ug/ml), E.clocae (MIC >100 ug/ml), P. multocida (MIC 25 ug/ml), and P.
Evidence 33 Activity

Activity

MIC
Antiviral
25 µg/mL

Target

S. uberis

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

ug/ml), S. aureus ATCC 25923 or 29213 (MIC 6-12.5 ug/ml, S. epidermidis (MIC 12.5 ug/ml), S. uberis (MIC 25 ug/ml), E.clocae (MIC >100 ug/ml), P. multocida (MIC 25 ug/ml), and P. haemolytica (MIC 50 ug/ml
Evidence 34 Activity

Activity

MIC
Antiviral
>100 µg/mL

Target

E.clocae

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

23 or 29213 (MIC 6-12.5 ug/ml, S. epidermidis (MIC 12.5 ug/ml), S. uberis (MIC 25 ug/ml), E.clocae (MIC >100 ug/ml), P. multocida (MIC 25 ug/ml), and P. haemolytica (MIC 50 ug/ml) (same ref as AP2008). It
Evidence 35 Activity

Activity

MIC
Antiviral
25 µg/mL

Target

P. multocida

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

ml, S. epidermidis (MIC 12.5 ug/ml), S. uberis (MIC 25 ug/ml), E.clocae (MIC >100 ug/ml), P. multocida (MIC 25 ug/ml), and P. haemolytica (MIC 50 ug/ml) (same ref as AP2008). It contains two amphipathic heli
Evidence 36 Activity

Activity

MIC
Antiviral
50 µg/mL

Target

P. haemolytica

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

l), S. uberis (MIC 25 ug/ml), E.clocae (MIC >100 ug/ml), P. multocida (MIC 25 ug/ml), and P. haemolytica (MIC 50 ug/ml) (same ref as AP2008). It contains two amphipathic helices separated by a region of less-d
Evidence 37 Activity

Activity

50% Cell death
Toxicity
10 µM
Cytotoxic
50% Cell death | 10 | µM | target cell: Human endocervical cells End1/E6E7

Target

Human endocervical cells End1/E6E7

Source & Reference

NA
DBAASP
Inhibition of HIV Infection by Caerin 1 Antimicrobial Peptides | Peptides | 2015
Evidence 38 Activity

Activity

Toxicity
Cytotoxic
Cytotoxicity: [Ref.26026377]Human endocervical cells End1/E6E7:50% cell death at 10 µM.

Source & Reference

NA
DRAMP
Peptides. 2015 Sep 71:296-303. ##J Pept Sci. 1997 May-Jun 3(3):181-185.##Rapid Commun Mass Spectrom. 1997 11(9):997-1000.##J Pept Res. 1998 Feb 51(2):121-126.