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Peptide record

TPDB04965

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB04965
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb i2APP ToxinPred 3.0
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLIGMTHGLICLISRKC
Physicochemical Analysis
C85H145N23O20S3
ANDEQPWYV
IL
1905.41
9.15
3
0
8
+2
-1.40
1.218
137.65
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
125
6.56
4
Residue Composition
number
0
A
1
R
0
N
0
D
2
C
0
E
0
Q
2
G
1
H
3
I
3
L
1
K
1
M
1
F
0
P
1
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 2 H: 1 I: 3 L: 3 K: 1 M: 1 F: 1 P: 0 S: 1 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
17
C85H145N23O20S3
1905.41
9.15
+2
-1.40
1.218
Evidence Records 23 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6.6 µM

Target

M. luteus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against M. luteus (MIC 6.6 uM), S. aureus (MIC 13.1 uM), B. subtilis (MIC 26.3 uM), S. epidermidis (MIC 31.5 uM), S.dyse
Evidence 2 Activity

Activity

MIC
Antibacterial
13.1 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Active against M. luteus (MIC 6.6 uM), S. aureus (MIC 13.1 uM), B. subtilis (MIC 26.3 uM), S. epidermidis (MIC 31.5 uM), S.dysenteriae (MIC >100 ug/ml),
Evidence 3 Activity

Activity

MIC
Antibacterial
26.3 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

Active against M. luteus (MIC 6.6 uM), S. aureus (MIC 13.1 uM), B. subtilis (MIC 26.3 uM), S. epidermidis (MIC 31.5 uM), S.dysenteriae (MIC >100 ug/ml), E.coli (MIC >100 ug/mml),
Evidence 4 Activity

Activity

MIC
Antibacterial
31.5 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP DRAMP

Other

ctive against M. luteus (MIC 6.6 uM), S. aureus (MIC 13.1 uM), B. subtilis (MIC 26.3 uM), S. epidermidis (MIC 31.5 uM), S.dysenteriae (MIC >100 ug/ml), E.coli (MIC >100 ug/mml), K.pneumoniae (MIC > 100 ug/ml)
Evidence 5 Activity

Activity

MIC
Antibacterial
>100 µg/mL

Target

S.dysenteriae

Source & Reference

dbAMP DRAMP

Other

.6 uM), S. aureus (MIC 13.1 uM), B. subtilis (MIC 26.3 uM), S. epidermidis (MIC 31.5 uM), S.dysenteriae (MIC >100 ug/ml), E.coli (MIC >100 ug/mml), K.pneumoniae (MIC > 100 ug/ml), P.mirabilis (MIC> 100 ug/ml),
Evidence 6 Activity

Activity

MIC
Antibacterial
>100 µg/mL

Target

P.aeruginosa

Source & Reference

dbAMP DRAMP

Other

, E.coli (MIC >100 ug/mml), K.pneumoniae (MIC > 100 ug/ml), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml), and C.albicans (MIC >100 ug/ml).
Evidence 7 Activity

Activity

MIC
Antibacterial
>100 µg/mL

Target

C.albicans

Source & Reference

dbAMP DRAMP

Other

moniae (MIC > 100 ug/ml), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml), and C.albicans (MIC >100 ug/ml).
Evidence 8 Activity

Activity

MIC
Antifungal
6.6 µM

Target

M. luteus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against M. luteus (MIC 6.6 uM), S. aureus (MIC 13.1 uM), B. subtilis (MIC 26.3 uM), S. epidermidis (MIC 31.5 uM), S.dyse
Evidence 9 Activity

Activity

MIC
Antifungal
13.1 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against M. luteus (MIC 6.6 uM), S. aureus (MIC 13.1 uM), B. subtilis (MIC 26.3 uM), S. epidermidis (MIC 31.5 uM), S.dysenteriae (MIC >100 ug/ml),
Evidence 10 Activity

Activity

MIC
Antifungal
26.3 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against M. luteus (MIC 6.6 uM), S. aureus (MIC 13.1 uM), B. subtilis (MIC 26.3 uM), S. epidermidis (MIC 31.5 uM), S.dysenteriae (MIC >100 ug/ml), E.coli (MIC >100 ug/mml),
Evidence 11 Activity

Activity

MIC
Antifungal
31.5 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ctive against M. luteus (MIC 6.6 uM), S. aureus (MIC 13.1 uM), B. subtilis (MIC 26.3 uM), S. epidermidis (MIC 31.5 uM), S.dysenteriae (MIC >100 ug/ml), E.coli (MIC >100 ug/mml), K.pneumoniae (MIC > 100 ug/ml)
Evidence 12 Activity

Activity

MIC
Antifungal
>100 µg/mL

Target

S.dysenteriae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

.6 uM), S. aureus (MIC 13.1 uM), B. subtilis (MIC 26.3 uM), S. epidermidis (MIC 31.5 uM), S.dysenteriae (MIC >100 ug/ml), E.coli (MIC >100 ug/mml), K.pneumoniae (MIC > 100 ug/ml), P.mirabilis (MIC> 100 ug/ml),
Evidence 13 Activity

Activity

MIC
Antifungal
>100 µg/mL

Target

P.aeruginosa

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

, E.coli (MIC >100 ug/mml), K.pneumoniae (MIC > 100 ug/ml), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml), and C.albicans (MIC >100 ug/ml).
Evidence 14 Activity

Activity

MIC
Antifungal
>100 µg/mL

Target

C.albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

moniae (MIC > 100 ug/ml), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml), and C.albicans (MIC >100 ug/ml).
Evidence 15 Activity

Activity

MIC
Antiparasitic
6.6 µM

Target

M. luteus

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against M. luteus (MIC 6.6 uM), S. aureus (MIC 13.1 uM), B. subtilis (MIC 26.3 uM), S. epidermidis (MIC 31.5 uM), S.dyse
Evidence 16 Activity

Activity

MIC
Antiparasitic
13.1 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Active against M. luteus (MIC 6.6 uM), S. aureus (MIC 13.1 uM), B. subtilis (MIC 26.3 uM), S. epidermidis (MIC 31.5 uM), S.dysenteriae (MIC >100 ug/ml),
Evidence 17 Activity

Activity

MIC
Antiparasitic
26.3 µM

Target

B. subtilis

Source & Reference

DRAMP

Other

Active against M. luteus (MIC 6.6 uM), S. aureus (MIC 13.1 uM), B. subtilis (MIC 26.3 uM), S. epidermidis (MIC 31.5 uM), S.dysenteriae (MIC >100 ug/ml), E.coli (MIC >100 ug/mml),
Evidence 18 Activity

Activity

MIC
Antiparasitic
31.5 µM

Target

Staphylococcus epidermidis

Source & Reference

DRAMP

Other

ctive against M. luteus (MIC 6.6 uM), S. aureus (MIC 13.1 uM), B. subtilis (MIC 26.3 uM), S. epidermidis (MIC 31.5 uM), S.dysenteriae (MIC >100 ug/ml), E.coli (MIC >100 ug/mml), K.pneumoniae (MIC > 100 ug/ml)
Evidence 19 Activity

Activity

MIC
Antiparasitic
>100 µg/mL

Target

S.dysenteriae

Source & Reference

DRAMP

Other

.6 uM), S. aureus (MIC 13.1 uM), B. subtilis (MIC 26.3 uM), S. epidermidis (MIC 31.5 uM), S.dysenteriae (MIC >100 ug/ml), E.coli (MIC >100 ug/mml), K.pneumoniae (MIC > 100 ug/ml), P.mirabilis (MIC> 100 ug/ml),
Evidence 20 Activity

Activity

MIC
Antiparasitic
>100 µg/mL

Target

P.aeruginosa

Source & Reference

DRAMP

Other

, E.coli (MIC >100 ug/mml), K.pneumoniae (MIC > 100 ug/ml), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml), and C.albicans (MIC >100 ug/ml).
Evidence 21 Activity

Activity

MIC
Antiparasitic
>100 µg/mL

Target

C.albicans

Source & Reference

DRAMP

Other

moniae (MIC > 100 ug/ml), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml), and C.albicans (MIC >100 ug/ml).
Evidence 22 Activity

Activity

1% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
1% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Purification and characterization of antimicrobial peptides from the skin secretion of Rana dybowskii. | Peptides | 2007
Evidence 23 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref:17698251] It has 0.99% hemolytic activity at 100 µg/ml against huamn red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides 2007 28: 1532-1539.