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Peptide record

TPDB04953

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
34 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB04953
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF Antifungipept dbAMP 3.0 i2APP APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 34-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GCASRCKAKCAGRRCKGWASASFRGRCYCKCFRC
Physicochemical Analysis
C154H251N57O39S8
NDEQHILMPTV
C
3781.53
10.02
10
0
9
+10
1.43
-0.418
14.71
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
7490
198.07
12
Residue Composition
number
5
A
6
R
0
N
0
D
8
C
0
E
0
Q
4
G
0
H
0
I
0
L
4
K
0
M
2
F
0
P
3
S
0
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 5 R: 6 N: 0 D: 0 C: 8 E: 0 Q: 0 G: 4 H: 0 I: 0 L: 0 K: 4 M: 0 F: 2 P: 0 S: 3 T: 0 W: 1 Y: 1 V: 0
Chemical Descriptors
34
C154H251N57O39S8
3781.53
10.02
+10
1.43
-0.418
Evidence Records 43 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.6-1.2 µM

Target

M. luteus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against Gram+ M. luteus (MIC 0.6-1.2 uM), A. viridans (MIC 0.6-1.2 uM), B. megaterium (MIC 0.6-1.2 uM), E. faecalis (MIC 2.5-5 uM)
Evidence 2 Activity

Activity

MIC
Antibacterial
0.6-1.2 µM

Target

A. viridans

Source & Reference

dbAMP DRAMP

Other

Active against Gram+ M. luteus (MIC 0.6-1.2 uM), A. viridans (MIC 0.6-1.2 uM), B. megaterium (MIC 0.6-1.2 uM), E. faecalis (MIC 2.5-5 uM), S. aureus (MIC 5-10 uM), Gra
Evidence 3 Activity

Activity

MIC
Antibacterial
0.6-1.2 µM

Target

B. megaterium

Source & Reference

dbAMP DRAMP

Other

Active against Gram+ M. luteus (MIC 0.6-1.2 uM), A. viridans (MIC 0.6-1.2 uM), B. megaterium (MIC 0.6-1.2 uM), E. faecalis (MIC 2.5-5 uM), S. aureus (MIC 5-10 uM), Gram- E. coli D31 (MIC 2.5-5 uM), E
Evidence 4 Activity

Activity

MIC
Antibacterial
2.5-5 µM

Target

Enterococcus faecalis

Source & Reference

dbAMP DRAMP

Other

M. luteus (MIC 0.6-1.2 uM), A. viridans (MIC 0.6-1.2 uM), B. megaterium (MIC 0.6-1.2 uM), E. faecalis (MIC 2.5-5 uM), S. aureus (MIC 5-10 uM), Gram- E. coli D31 (MIC 2.5-5 uM), E. coli D22 (MIC 5-10 uM), E-
Evidence 5 Activity

Activity

MIC
Antibacterial
5-10 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

A. viridans (MIC 0.6-1.2 uM), B. megaterium (MIC 0.6-1.2 uM), E. faecalis (MIC 2.5-5 uM), S. aureus (MIC 5-10 uM), Gram- E. coli D31 (MIC 2.5-5 uM), E. coli D22 (MIC 5-10 uM), E-coli 1106 (MIC >10 uM), S
Evidence 6 Activity

Activity

MIC
Antibacterial
2.5-5 µM

Target

Escherichia coli D31

Source & Reference

dbAMP DRAMP

Other

. megaterium (MIC 0.6-1.2 uM), E. faecalis (MIC 2.5-5 uM), S. aureus (MIC 5-10 uM), Gram- E. coli D31 (MIC 2.5-5 uM), E. coli D22 (MIC 5-10 uM), E-coli 1106 (MIC >10 uM), S-typhimurium (MIC >10 uM), A. carr
Evidence 7 Activity

Activity

MIC
Antibacterial
5-10 µM

Target

Escherichia coli D22

Source & Reference

dbAMP DRAMP

Other

), E. faecalis (MIC 2.5-5 uM), S. aureus (MIC 5-10 uM), Gram- E. coli D31 (MIC 2.5-5 uM), E. coli D22 (MIC 5-10 uM), E-coli 1106 (MIC >10 uM), S-typhimurium (MIC >10 uM), A. carrageenovora (MIC 2.5-5 uM),
Evidence 8 Activity

Activity

MIC
Antibacterial
2.5-5 µM

Target

A. carrageenovora

Source & Reference

dbAMP DRAMP

Other

5-5 uM), E. coli D22 (MIC 5-10 uM), E-coli 1106 (MIC >10 uM), S-typhimurium (MIC >10 uM), A. carrageenovora (MIC 2.5-5 uM), P. alginovora (MIC 2.5-5 uM), C. drobachiensis (MIC 2.5-5 uM). UPdated 7/2021
Evidence 9 Activity

Activity

MIC
Antibacterial
2.5-5 µM

Target

P. alginovora

Source & Reference

dbAMP DRAMP

Other

, E-coli 1106 (MIC >10 uM), S-typhimurium (MIC >10 uM), A. carrageenovora (MIC 2.5-5 uM), P. alginovora (MIC 2.5-5 uM), C. drobachiensis (MIC 2.5-5 uM). UPdated 7/2021
Evidence 10 Activity

Activity

MIC
Antibacterial
2.5-5 µM

Target

C. drobachiensis

Source & Reference

dbAMP DRAMP

Other

typhimurium (MIC >10 uM), A. carrageenovora (MIC 2.5-5 uM), P. alginovora (MIC 2.5-5 uM), C. drobachiensis (MIC 2.5-5 uM). UPdated 7/2021
Evidence 11 Activity

Activity

MIC
Antifungal
0.6-1.2 µM

Target

M. luteus

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against Gram+ M. luteus (MIC 0.6-1.2 uM), A. viridans (MIC 0.6-1.2 uM), B. megaterium (MIC 0.6-1.2 uM), E. faecalis (MIC 2.5-5 uM)
Evidence 12 Activity

Activity

MIC
Antifungal
0.6-1.2 µM

Target

A. viridans

Source & Reference

dbAMP DRAMP Antifungipept

Other

Active against Gram+ M. luteus (MIC 0.6-1.2 uM), A. viridans (MIC 0.6-1.2 uM), B. megaterium (MIC 0.6-1.2 uM), E. faecalis (MIC 2.5-5 uM), S. aureus (MIC 5-10 uM), Gra
Evidence 13 Activity

Activity

MIC
Antifungal
0.6-1.2 µM

Target

B. megaterium

Source & Reference

dbAMP DRAMP Antifungipept

Other

Active against Gram+ M. luteus (MIC 0.6-1.2 uM), A. viridans (MIC 0.6-1.2 uM), B. megaterium (MIC 0.6-1.2 uM), E. faecalis (MIC 2.5-5 uM), S. aureus (MIC 5-10 uM), Gram- E. coli D31 (MIC 2.5-5 uM), E
Evidence 14 Activity

Activity

MIC
Antifungal
2.5-5 µM

Target

Enterococcus faecalis

Source & Reference

dbAMP DRAMP Antifungipept

Other

M. luteus (MIC 0.6-1.2 uM), A. viridans (MIC 0.6-1.2 uM), B. megaterium (MIC 0.6-1.2 uM), E. faecalis (MIC 2.5-5 uM), S. aureus (MIC 5-10 uM), Gram- E. coli D31 (MIC 2.5-5 uM), E. coli D22 (MIC 5-10 uM), E-
Evidence 15 Activity

Activity

MIC
Antifungal
5-10 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP Antifungipept

Other

A. viridans (MIC 0.6-1.2 uM), B. megaterium (MIC 0.6-1.2 uM), E. faecalis (MIC 2.5-5 uM), S. aureus (MIC 5-10 uM), Gram- E. coli D31 (MIC 2.5-5 uM), E. coli D22 (MIC 5-10 uM), E-coli 1106 (MIC >10 uM), S
Evidence 16 Activity

Activity

MIC
Antifungal
2.5-5 µM

Target

Escherichia coli D31

Source & Reference

dbAMP DRAMP Antifungipept

Other

. megaterium (MIC 0.6-1.2 uM), E. faecalis (MIC 2.5-5 uM), S. aureus (MIC 5-10 uM), Gram- E. coli D31 (MIC 2.5-5 uM), E. coli D22 (MIC 5-10 uM), E-coli 1106 (MIC >10 uM), S-typhimurium (MIC >10 uM), A. carr
Evidence 17 Activity

Activity

MIC
Antifungal
5-10 µM

Target

Escherichia coli D22

Source & Reference

dbAMP DRAMP Antifungipept

Other

), E. faecalis (MIC 2.5-5 uM), S. aureus (MIC 5-10 uM), Gram- E. coli D31 (MIC 2.5-5 uM), E. coli D22 (MIC 5-10 uM), E-coli 1106 (MIC >10 uM), S-typhimurium (MIC >10 uM), A. carrageenovora (MIC 2.5-5 uM),
Evidence 18 Activity

Activity

MIC
Antifungal
2.5-5 µM

Target

A. carrageenovora

Source & Reference

dbAMP DRAMP Antifungipept

Other

5-5 uM), E. coli D22 (MIC 5-10 uM), E-coli 1106 (MIC >10 uM), S-typhimurium (MIC >10 uM), A. carrageenovora (MIC 2.5-5 uM), P. alginovora (MIC 2.5-5 uM), C. drobachiensis (MIC 2.5-5 uM). UPdated 7/2021
Evidence 19 Activity

Activity

MIC
Antifungal
2.5-5 µM

Target

P. alginovora

Source & Reference

dbAMP DRAMP Antifungipept

Other

, E-coli 1106 (MIC >10 uM), S-typhimurium (MIC >10 uM), A. carrageenovora (MIC 2.5-5 uM), P. alginovora (MIC 2.5-5 uM), C. drobachiensis (MIC 2.5-5 uM). UPdated 7/2021
Evidence 20 Activity

Activity

MIC
Antifungal
2.5-5 µM

Target

C. drobachiensis

Source & Reference

dbAMP DRAMP Antifungipept

Other

typhimurium (MIC >10 uM), A. carrageenovora (MIC 2.5-5 uM), P. alginovora (MIC 2.5-5 uM), C. drobachiensis (MIC 2.5-5 uM). UPdated 7/2021
Evidence 21 Activity

Activity

MIC
Antiparasitic
0.6-1.2 µM

Target

M. luteus

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
Active against Gram+ M. luteus (MIC 0.6-1.2 uM), A. viridans (MIC 0.6-1.2 uM), B. megaterium (MIC 0.6-1.2 uM), E. faecalis (MIC 2.5-5 uM)
Evidence 22 Activity

Activity

MIC
Antiparasitic
0.6-1.2 µM

Target

A. viridans

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against Gram+ M. luteus (MIC 0.6-1.2 uM), A. viridans (MIC 0.6-1.2 uM), B. megaterium (MIC 0.6-1.2 uM), E. faecalis (MIC 2.5-5 uM), S. aureus (MIC 5-10 uM), Gra
Evidence 23 Activity

Activity

MIC
Antiparasitic
0.6-1.2 µM

Target

B. megaterium

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against Gram+ M. luteus (MIC 0.6-1.2 uM), A. viridans (MIC 0.6-1.2 uM), B. megaterium (MIC 0.6-1.2 uM), E. faecalis (MIC 2.5-5 uM), S. aureus (MIC 5-10 uM), Gram- E. coli D31 (MIC 2.5-5 uM), E
Evidence 24 Activity

Activity

MIC
Antiparasitic
2.5-5 µM

Target

Enterococcus faecalis

Source & Reference

dbAMP 3.0 DRAMP

Other

M. luteus (MIC 0.6-1.2 uM), A. viridans (MIC 0.6-1.2 uM), B. megaterium (MIC 0.6-1.2 uM), E. faecalis (MIC 2.5-5 uM), S. aureus (MIC 5-10 uM), Gram- E. coli D31 (MIC 2.5-5 uM), E. coli D22 (MIC 5-10 uM), E-
Evidence 25 Activity

Activity

MIC
Antiparasitic
5-10 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP 3.0 DRAMP

Other

A. viridans (MIC 0.6-1.2 uM), B. megaterium (MIC 0.6-1.2 uM), E. faecalis (MIC 2.5-5 uM), S. aureus (MIC 5-10 uM), Gram- E. coli D31 (MIC 2.5-5 uM), E. coli D22 (MIC 5-10 uM), E-coli 1106 (MIC >10 uM), S
Evidence 26 Activity

Activity

MIC
Antiparasitic
2.5-5 µM

Target

Escherichia coli D31

Source & Reference

dbAMP 3.0 DRAMP

Other

. megaterium (MIC 0.6-1.2 uM), E. faecalis (MIC 2.5-5 uM), S. aureus (MIC 5-10 uM), Gram- E. coli D31 (MIC 2.5-5 uM), E. coli D22 (MIC 5-10 uM), E-coli 1106 (MIC >10 uM), S-typhimurium (MIC >10 uM), A. carr
Evidence 27 Activity

Activity

MIC
Antiparasitic
5-10 µM

Target

Escherichia coli D22

Source & Reference

dbAMP 3.0 DRAMP

Other

), E. faecalis (MIC 2.5-5 uM), S. aureus (MIC 5-10 uM), Gram- E. coli D31 (MIC 2.5-5 uM), E. coli D22 (MIC 5-10 uM), E-coli 1106 (MIC >10 uM), S-typhimurium (MIC >10 uM), A. carrageenovora (MIC 2.5-5 uM),
Evidence 28 Activity

Activity

MIC
Antiparasitic
2.5-5 µM

Target

A. carrageenovora

Source & Reference

dbAMP 3.0 DRAMP

Other

5-5 uM), E. coli D22 (MIC 5-10 uM), E-coli 1106 (MIC >10 uM), S-typhimurium (MIC >10 uM), A. carrageenovora (MIC 2.5-5 uM), P. alginovora (MIC 2.5-5 uM), C. drobachiensis (MIC 2.5-5 uM). UPdated 7/2021
Evidence 29 Activity

Activity

MIC
Antiparasitic
2.5-5 µM

Target

P. alginovora

Source & Reference

dbAMP 3.0 DRAMP

Other

, E-coli 1106 (MIC >10 uM), S-typhimurium (MIC >10 uM), A. carrageenovora (MIC 2.5-5 uM), P. alginovora (MIC 2.5-5 uM), C. drobachiensis (MIC 2.5-5 uM). UPdated 7/2021
Evidence 30 Activity

Activity

MIC
Antiparasitic
2.5-5 µM

Target

C. drobachiensis

Source & Reference

dbAMP 3.0 DRAMP

Other

typhimurium (MIC >10 uM), A. carrageenovora (MIC 2.5-5 uM), P. alginovora (MIC 2.5-5 uM), C. drobachiensis (MIC 2.5-5 uM). UPdated 7/2021
Evidence 31 Activity

Activity

MIC
Antiviral
0.6-1.2 µM

Target

M. luteus

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.
Active against Gram+ M. luteus (MIC 0.6-1.2 uM), A. viridans (MIC 0.6-1.2 uM), B. megaterium (MIC 0.6-1.2 uM), E. faecalis (MIC 2.5-5 uM)
Evidence 32 Activity

Activity

MIC
Antiviral
0.6-1.2 µM

Target

A. viridans

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against Gram+ M. luteus (MIC 0.6-1.2 uM), A. viridans (MIC 0.6-1.2 uM), B. megaterium (MIC 0.6-1.2 uM), E. faecalis (MIC 2.5-5 uM), S. aureus (MIC 5-10 uM), Gra
Evidence 33 Activity

Activity

MIC
Antiviral
0.6-1.2 µM

Target

B. megaterium

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against Gram+ M. luteus (MIC 0.6-1.2 uM), A. viridans (MIC 0.6-1.2 uM), B. megaterium (MIC 0.6-1.2 uM), E. faecalis (MIC 2.5-5 uM), S. aureus (MIC 5-10 uM), Gram- E. coli D31 (MIC 2.5-5 uM), E
Evidence 34 Activity

Activity

MIC
Antiviral
2.5-5 µM

Target

Enterococcus faecalis

Source & Reference

dbAMP 3.0 DRAMP

Other

M. luteus (MIC 0.6-1.2 uM), A. viridans (MIC 0.6-1.2 uM), B. megaterium (MIC 0.6-1.2 uM), E. faecalis (MIC 2.5-5 uM), S. aureus (MIC 5-10 uM), Gram- E. coli D31 (MIC 2.5-5 uM), E. coli D22 (MIC 5-10 uM), E-
Evidence 35 Activity

Activity

MIC
Antiviral
5-10 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP 3.0 DRAMP

Other

A. viridans (MIC 0.6-1.2 uM), B. megaterium (MIC 0.6-1.2 uM), E. faecalis (MIC 2.5-5 uM), S. aureus (MIC 5-10 uM), Gram- E. coli D31 (MIC 2.5-5 uM), E. coli D22 (MIC 5-10 uM), E-coli 1106 (MIC >10 uM), S
Evidence 36 Activity

Activity

MIC
Antiviral
2.5-5 µM

Target

Escherichia coli D31

Source & Reference

dbAMP 3.0 DRAMP

Other

. megaterium (MIC 0.6-1.2 uM), E. faecalis (MIC 2.5-5 uM), S. aureus (MIC 5-10 uM), Gram- E. coli D31 (MIC 2.5-5 uM), E. coli D22 (MIC 5-10 uM), E-coli 1106 (MIC >10 uM), S-typhimurium (MIC >10 uM), A. carr
Evidence 37 Activity

Activity

MIC
Antiviral
5-10 µM

Target

Escherichia coli D22

Source & Reference

dbAMP 3.0 DRAMP

Other

), E. faecalis (MIC 2.5-5 uM), S. aureus (MIC 5-10 uM), Gram- E. coli D31 (MIC 2.5-5 uM), E. coli D22 (MIC 5-10 uM), E-coli 1106 (MIC >10 uM), S-typhimurium (MIC >10 uM), A. carrageenovora (MIC 2.5-5 uM),
Evidence 38 Activity

Activity

MIC
Antiviral
2.5-5 µM

Target

A. carrageenovora

Source & Reference

dbAMP 3.0 DRAMP

Other

5-5 uM), E. coli D22 (MIC 5-10 uM), E-coli 1106 (MIC >10 uM), S-typhimurium (MIC >10 uM), A. carrageenovora (MIC 2.5-5 uM), P. alginovora (MIC 2.5-5 uM), C. drobachiensis (MIC 2.5-5 uM). UPdated 7/2021
Evidence 39 Activity

Activity

MIC
Antiviral
2.5-5 µM

Target

P. alginovora

Source & Reference

dbAMP 3.0 DRAMP

Other

, E-coli 1106 (MIC >10 uM), S-typhimurium (MIC >10 uM), A. carrageenovora (MIC 2.5-5 uM), P. alginovora (MIC 2.5-5 uM), C. drobachiensis (MIC 2.5-5 uM). UPdated 7/2021
Evidence 40 Activity

Activity

MIC
Antiviral
2.5-5 µM

Target

C. drobachiensis

Source & Reference

dbAMP 3.0 DRAMP

Other

typhimurium (MIC >10 uM), A. carrageenovora (MIC 2.5-5 uM), P. alginovora (MIC 2.5-5 uM), C. drobachiensis (MIC 2.5-5 uM). UPdated 7/2021
Evidence 41 Activity

Activity

0% Hemolysis
Toxicity
6.2 µM
Hemolytic Cytotoxic
0% Hemolysis | 6.2 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Trypanocidal and leishmanicidal activities of different antimicrobial peptides (AMPs) isolated from aquatic animals. | Exp Parasitol | 2008
Evidence 42 Activity

Activity

10% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
10% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Trypanocidal and leishmanicidal activities of different antimicrobial peptides (AMPs) isolated from aquatic animals. | Exp Parasitol | 2008
Evidence 43 Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.