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Peptide record

TPDB04952

Urechistachykinin-2 Antibacterial Anticancer Antifungal Antiparasitic Neuropeptide Toxicity standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB04952
Urechistachykinin-2
Antibacterial Anticancer Antifungal Antiparasitic Neuropeptide Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Neuroactive peptides
AntiBP3 dbAMP DRAMP Peptipedia CAFPdb ToxinPred 3.0
standard
No
A 10-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
AAGMGFFGAR
Physicochemical Analysis
C44H65N13O11S1
NDCEQHILKPSTWYV
AG
984.14
11.05
1
0
6
+1
-2.16
0.720
30.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
3
A
1
R
0
N
0
D
0
C
0
E
0
Q
3
G
0
H
0
I
0
L
0
K
1
M
2
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 0 L: 0 K: 0 M: 1 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
10
C44H65N13O11S1
984.14
11.05
+1
-2.16
0.720
Evidence Records 30 records
Evidence 1 Activity

Activity

MIC
Antibacterial
12.7 µM

Target

S. mutants

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against Gram+ bacteria S. mutants (MIC 12.7 uM), S. aureus (MIC 25.4 uM), and E. faecium (MIC 25.4 uM) and gram- bacteria E. coli O-157 (
Evidence 2 Activity

Activity

MIC
Antibacterial
25.4 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Active against Gram+ bacteria S. mutants (MIC 12.7 uM), S. aureus (MIC 25.4 uM), and E. faecium (MIC 25.4 uM) and gram- bacteria E. coli O-157 (MIC 12.7 uM), P. aerugino
Evidence 3 Activity

Activity

MIC
Antibacterial
25.4 µM

Target

E. faecium

Source & Reference

dbAMP DRAMP

Other

Active against Gram+ bacteria S. mutants (MIC 12.7 uM), S. aureus (MIC 25.4 uM), and E. faecium (MIC 25.4 uM) and gram- bacteria E. coli O-157 (MIC 12.7 uM), P. aeruginosa (MIC 12.7 uM), and V. vulni
Evidence 4 Activity

Activity

MIC
Antibacterial
12.7 µM

Target

Escherichia coli O-157

Source & Reference

dbAMP DRAMP

Other

s (MIC 12.7 uM), S. aureus (MIC 25.4 uM), and E. faecium (MIC 25.4 uM) and gram- bacteria E. coli O-157 (MIC 12.7 uM), P. aeruginosa (MIC 12.7 uM), and V. vulnificus (MIC 25.4 uM) and fungi C. albicans (MIC
Evidence 5 Activity

Activity

MIC
Antibacterial
12.7 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

IC 25.4 uM), and E. faecium (MIC 25.4 uM) and gram- bacteria E. coli O-157 (MIC 12.7 uM), P. aeruginosa (MIC 12.7 uM), and V. vulnificus (MIC 25.4 uM) and fungi C. albicans (MIC 25.4 uM), T. beigelii (MIC 12
Evidence 6 Activity

Activity

MIC
Antibacterial
25.4 µM

Target

V. vulnificus

Source & Reference

dbAMP DRAMP

Other

25.4 uM) and gram- bacteria E. coli O-157 (MIC 12.7 uM), P. aeruginosa (MIC 12.7 uM), and V. vulnificus (MIC 25.4 uM) and fungi C. albicans (MIC 25.4 uM), T. beigelii (MIC 12.7 uM), M. furfur (MIC 50.9 uM).
Evidence 7 Activity

Activity

MIC
Antibacterial
25.4 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

157 (MIC 12.7 uM), P. aeruginosa (MIC 12.7 uM), and V. vulnificus (MIC 25.4 uM) and fungi C. albicans (MIC 25.4 uM), T. beigelii (MIC 12.7 uM), M. furfur (MIC 50.9 uM).
Evidence 8 Activity

Activity

MIC
Antibacterial
12.7 µM

Target

T. beigelii

Source & Reference

dbAMP DRAMP

Other

inosa (MIC 12.7 uM), and V. vulnificus (MIC 25.4 uM) and fungi C. albicans (MIC 25.4 uM), T. beigelii (MIC 12.7 uM), M. furfur (MIC 50.9 uM).
Evidence 9 Activity

Activity

MIC
Antibacterial
50.9 µM

Target

M. furfur

Source & Reference

dbAMP DRAMP

Other

vulnificus (MIC 25.4 uM) and fungi C. albicans (MIC 25.4 uM), T. beigelii (MIC 12.7 uM), M. furfur (MIC 50.9 uM).
Evidence 10 Activity

Activity

MIC
Antifungal
12.7 µM

Target

S. mutants

Source & Reference

dbAMP DRAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against Gram+ bacteria S. mutants (MIC 12.7 uM), S. aureus (MIC 25.4 uM), and E. faecium (MIC 25.4 uM) and gram- bacteria E. coli O-157 (
Evidence 11 Activity

Activity

MIC
Antifungal
25.4 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb

Other

Active against Gram+ bacteria S. mutants (MIC 12.7 uM), S. aureus (MIC 25.4 uM), and E. faecium (MIC 25.4 uM) and gram- bacteria E. coli O-157 (MIC 12.7 uM), P. aerugino
Evidence 12 Activity

Activity

MIC
Antifungal
25.4 µM

Target

E. faecium

Source & Reference

dbAMP DRAMP CAFPdb

Other

Active against Gram+ bacteria S. mutants (MIC 12.7 uM), S. aureus (MIC 25.4 uM), and E. faecium (MIC 25.4 uM) and gram- bacteria E. coli O-157 (MIC 12.7 uM), P. aeruginosa (MIC 12.7 uM), and V. vulni
Evidence 13 Activity

Activity

MIC
Antifungal
12.7 µM

Target

Escherichia coli O-157

Source & Reference

dbAMP DRAMP CAFPdb

Other

s (MIC 12.7 uM), S. aureus (MIC 25.4 uM), and E. faecium (MIC 25.4 uM) and gram- bacteria E. coli O-157 (MIC 12.7 uM), P. aeruginosa (MIC 12.7 uM), and V. vulnificus (MIC 25.4 uM) and fungi C. albicans (MIC
Evidence 14 Activity

Activity

MIC
Antifungal
12.7 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP CAFPdb

Other

IC 25.4 uM), and E. faecium (MIC 25.4 uM) and gram- bacteria E. coli O-157 (MIC 12.7 uM), P. aeruginosa (MIC 12.7 uM), and V. vulnificus (MIC 25.4 uM) and fungi C. albicans (MIC 25.4 uM), T. beigelii (MIC 12
Evidence 15 Activity

Activity

MIC
Antifungal
25.4 µM

Target

V. vulnificus

Source & Reference

dbAMP DRAMP CAFPdb

Other

25.4 uM) and gram- bacteria E. coli O-157 (MIC 12.7 uM), P. aeruginosa (MIC 12.7 uM), and V. vulnificus (MIC 25.4 uM) and fungi C. albicans (MIC 25.4 uM), T. beigelii (MIC 12.7 uM), M. furfur (MIC 50.9 uM).
Evidence 16 Activity

Activity

MIC
Antifungal
25.4 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb

Other

157 (MIC 12.7 uM), P. aeruginosa (MIC 12.7 uM), and V. vulnificus (MIC 25.4 uM) and fungi C. albicans (MIC 25.4 uM), T. beigelii (MIC 12.7 uM), M. furfur (MIC 50.9 uM).
Evidence 17 Activity

Activity

MIC
Antifungal
12.7 µM

Target

T. beigelii

Source & Reference

dbAMP DRAMP CAFPdb

Other

inosa (MIC 12.7 uM), and V. vulnificus (MIC 25.4 uM) and fungi C. albicans (MIC 25.4 uM), T. beigelii (MIC 12.7 uM), M. furfur (MIC 50.9 uM).
Evidence 18 Activity

Activity

MIC
Antifungal
50.9 µM

Target

M. furfur

Source & Reference

dbAMP DRAMP CAFPdb

Other

vulnificus (MIC 25.4 uM) and fungi C. albicans (MIC 25.4 uM), T. beigelii (MIC 12.7 uM), M. furfur (MIC 50.9 uM).
Evidence 19 Activity

Activity

MIC
Antiparasitic
12.7 µM

Target

S. mutants

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against Gram+ bacteria S. mutants (MIC 12.7 uM), S. aureus (MIC 25.4 uM), and E. faecium (MIC 25.4 uM) and gram- bacteria E. coli O-157 (
Evidence 20 Activity

Activity

MIC
Antiparasitic
25.4 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Active against Gram+ bacteria S. mutants (MIC 12.7 uM), S. aureus (MIC 25.4 uM), and E. faecium (MIC 25.4 uM) and gram- bacteria E. coli O-157 (MIC 12.7 uM), P. aerugino
Evidence 21 Activity

Activity

MIC
Antiparasitic
25.4 µM

Target

E. faecium

Source & Reference

DRAMP

Other

Active against Gram+ bacteria S. mutants (MIC 12.7 uM), S. aureus (MIC 25.4 uM), and E. faecium (MIC 25.4 uM) and gram- bacteria E. coli O-157 (MIC 12.7 uM), P. aeruginosa (MIC 12.7 uM), and V. vulni
Evidence 22 Activity

Activity

MIC
Antiparasitic
12.7 µM

Target

Escherichia coli O-157

Source & Reference

DRAMP

Other

s (MIC 12.7 uM), S. aureus (MIC 25.4 uM), and E. faecium (MIC 25.4 uM) and gram- bacteria E. coli O-157 (MIC 12.7 uM), P. aeruginosa (MIC 12.7 uM), and V. vulnificus (MIC 25.4 uM) and fungi C. albicans (MIC
Evidence 23 Activity

Activity

MIC
Antiparasitic
12.7 µM

Target

Pseudomonas aeruginosa

Source & Reference

DRAMP

Other

IC 25.4 uM), and E. faecium (MIC 25.4 uM) and gram- bacteria E. coli O-157 (MIC 12.7 uM), P. aeruginosa (MIC 12.7 uM), and V. vulnificus (MIC 25.4 uM) and fungi C. albicans (MIC 25.4 uM), T. beigelii (MIC 12
Evidence 24 Activity

Activity

MIC
Antiparasitic
25.4 µM

Target

V. vulnificus

Source & Reference

DRAMP

Other

25.4 uM) and gram- bacteria E. coli O-157 (MIC 12.7 uM), P. aeruginosa (MIC 12.7 uM), and V. vulnificus (MIC 25.4 uM) and fungi C. albicans (MIC 25.4 uM), T. beigelii (MIC 12.7 uM), M. furfur (MIC 50.9 uM).
Evidence 25 Activity

Activity

MIC
Antiparasitic
25.4 µM

Target

Candida albicans

Source & Reference

DRAMP

Other

157 (MIC 12.7 uM), P. aeruginosa (MIC 12.7 uM), and V. vulnificus (MIC 25.4 uM) and fungi C. albicans (MIC 25.4 uM), T. beigelii (MIC 12.7 uM), M. furfur (MIC 50.9 uM).
Evidence 26 Activity

Activity

MIC
Antiparasitic
12.7 µM

Target

T. beigelii

Source & Reference

DRAMP

Other

inosa (MIC 12.7 uM), and V. vulnificus (MIC 25.4 uM) and fungi C. albicans (MIC 25.4 uM), T. beigelii (MIC 12.7 uM), M. furfur (MIC 50.9 uM).
Evidence 27 Activity

Activity

MIC
Antiparasitic
50.9 µM

Target

M. furfur

Source & Reference

DRAMP

Other

vulnificus (MIC 25.4 uM) and fungi C. albicans (MIC 25.4 uM), T. beigelii (MIC 12.7 uM), M. furfur (MIC 50.9 uM).
Evidence 28 Activity

Activity

Neuropeptide

Source & Reference

NA
NeuroPepV2

Other

Urechis unicinctus
Tachykinin
Evidence 29 Activity

Activity

0% Hemolysis
Toxicity
3.12-100 µM
Hemolytic Cytotoxic
0% Hemolysis | 3.12-100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial effect and membrane-active mechanism of Urechistachykinins, neuropeptides derived from Urechis unicinctus. | FEBS Lett | 2008
Evidence 30 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.18570895] Has no hemolytic activities against human erythrocyte cells.

Target

erythrocytes

Source & Reference

NA
DRAMP
FEBS Lett. 2008 Jul 9 582(16):2463-2466.
Additional Detail Fields 1 fields
Tachykinin