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Peptide record

TPDB04948

Ranatuerin-2Lb Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
32 amino acids
Basic Information
3D PDB MODEL
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TPDB04948
Ranatuerin-2Lb
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia CancerPPD 2.0 AFP-GFuse Antifungipept CAFPdb i2APP APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 32-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GILSSIKGVAKGVAKNVAAQLLDTLKCKITGC
Physicochemical Analysis
C140H251N39O41S2
REHMFPWY
K
3200.89
10.06
5
1
14
+4
3.64
0.591
125.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
3.91
8
Residue Composition
number
4
A
0
R
1
N
1
D
2
C
0
E
1
Q
4
G
0
H
3
I
4
L
5
K
0
M
0
F
0
P
2
S
2
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 4 R: 0 N: 1 D: 1 C: 2 E: 0 Q: 1 G: 4 H: 0 I: 3 L: 4 K: 5 M: 0 F: 0 P: 0 S: 2 T: 2 W: 0 Y: 0 V: 3
Chemical Descriptors
32
C140H251N39O41S2
3200.89
10.06
+4
3.64
0.591
Free
L
Linear
Free
Anticancer
Rana luteiventris
Evidence Records 17 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
strongly active against S. aureus (MIC 4 uM), E. coli (MIC 4 uM), and weakly C. albicans (MIC 62 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
4 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

strongly active against S. aureus (MIC 4 uM), E. coli (MIC 4 uM), and weakly C. albicans (MIC 62 uM).
Evidence 3 Activity

Activity

MIC
Antibacterial
62 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

strongly active against S. aureus (MIC 4 uM), E. coli (MIC 4 uM), and weakly C. albicans (MIC 62 uM).
Evidence 4 Activity

Activity

IC50
IC50 = 15.32 µM
Anticancer
15.32 µM

Target

Lung Cancer
A-549
Lung

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2021

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 5 Activity

Activity

IC50
IC50 = 45.25 µM
Anticancer
45.25 µM

Target

Breast Cancer
MCF-7
Breast

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2021
Evidence 6 Activity

Activity

IC50
IC50 = 37.23 µM
Anticancer
37.23 µM

Target

Cervical Cancer
HeLa
Cervix

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2021
Evidence 7 Activity

Activity

IC50
IC50 = 59.78 µM
Anticancer
59.78 µM

Target

Colon Cancer
LoVo
Colon

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2021
Evidence 8 Activity

Activity

MIC
Antifungal
4 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
strongly active against S. aureus (MIC 4 uM), E. coli (MIC 4 uM), and weakly C. albicans (MIC 62 uM).
Evidence 9 Activity

Activity

MIC
Antifungal
4 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

strongly active against S. aureus (MIC 4 uM), E. coli (MIC 4 uM), and weakly C. albicans (MIC 62 uM).
Evidence 10 Activity

Activity

MIC
Antifungal
62 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

strongly active against S. aureus (MIC 4 uM), E. coli (MIC 4 uM), and weakly C. albicans (MIC 62 uM).
Evidence 11 Activity

Activity

MIC
Antiparasitic
4 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
strongly active against S. aureus (MIC 4 uM), E. coli (MIC 4 uM), and weakly C. albicans (MIC 62 uM).
Evidence 12 Activity

Activity

MIC
Antiparasitic
4 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

strongly active against S. aureus (MIC 4 uM), E. coli (MIC 4 uM), and weakly C. albicans (MIC 62 uM).
Evidence 13 Activity

Activity

MIC
Antiparasitic
62 µM

Target

Candida albicans

Source & Reference

DRAMP

Other

strongly active against S. aureus (MIC 4 uM), E. coli (MIC 4 uM), and weakly C. albicans (MIC 62 uM).
Evidence 14 Activity

Activity

50% Hemolysis
Toxicity
>100 µM
Hemolytic Cytotoxic
50% Hemolysis | >100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Host defense peptides in skin secretions of the Oregon spotted frog Rana pretiosa: implications for species resistance to chytridiomycosis. | Dev Comp Immunol | 2011
Evidence 15 Activity

Activity

IC50
Toxicity
63.16 µM
Cytotoxic
IC50 | 63.16 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Prediction of Anticancer Peptides with High Efficacy and Low Toxicity by Hybrid Model Based on 3D Structure of Peptides. | Int J Mol Sci | 2021
Evidence 16 Activity

Activity

<10% Hemolysis
Toxicity
256 µM
Hemolytic Cytotoxic
<10% Hemolysis | 256 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Prediction of Anticancer Peptides with High Efficacy and Low Toxicity by Hybrid Model Based on 3D Structure of Peptides. | Int J Mol Sci | 2021
Evidence 17 Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.