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Peptide record

TPDB04947

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
45 amino acids
Basic Information
3D PDB MODEL
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TPDB04947
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 45-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FKLGSFLKKAWKSKLAKKLRAKGKEMLKDYAKGLLEGGSEEVPGQ
Physicochemical Analysis
C229H379N61O61S1
NCHIT
K
4994.96
10.48
12
5
17
+7
12.68
-0.700
76.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
6990
139.94
5
Residue Composition
number
4
A
1
R
0
N
1
D
0
C
4
E
1
Q
6
G
0
H
0
I
7
L
11
K
1
M
2
F
1
P
3
S
0
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 4 R: 1 N: 0 D: 1 C: 0 E: 4 Q: 1 G: 6 H: 0 I: 0 L: 7 K: 11 M: 1 F: 2 P: 1 S: 3 T: 0 W: 1 Y: 1 V: 1
Chemical Descriptors
45
C229H379N61O61S1
4994.96
10.48
+7
12.68
-0.700
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
38 µM
Hemolytic Cytotoxic
50% Hemolysis | 38 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antibacterial and antifungal properties of alpha-helical, cationic peptides in the venom of scorpions from southern Africa. | Eur J Biochem | 2002
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
50 %
Hemolytic
Hemolytic_activity: [Ref.12354111]50% hemolysis is induced by about 38 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Eur J Biochem. 2002 Oct 269(19):4799-4810.##Toxicon. 2002 Dec 40(12):1679-1683.##iochem Biophys Res Commun. 2003 Nov 7 311(1):90-97.##Peptides. 2004 Jul 25(7):1079-1084.
Evidence 3 Hemolysis

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.