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Peptide record

TPDB04929

Antibacterial Anticancer Antifungal Antiparasitic standard

42 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB04929

Activity

Antibacterial Anticancer Antifungal Antiparasitic

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb

Sequence_Type

standard

Has_Modification No

Description A 42-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

EADEPLWLYKGDNIERAPTTADHPILPSIIDDVKLDPNRRYA

FASTA

>TPDB04929|Antibacterial;Anticancer;Antifungal;Antiparasitic|length=42
EADEPLWLYKGDNIERAPTTADHPILPSIIDDVKLDPNRRYA

Formula C215H334N58O68

Absent Amino Acids CQMF

Common Amino Acids D

Mass 4819.36

PI 4.30

Basic Residues 6

Acidic Residues 9

Hydrophobic Residues 16

Net Charge -4

Boman Index 14.50

Hydrophobicity -0.774

Aliphatic Index 90.71

Half Life

Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 8480

Absorbance 280nm 175.96

Polar Residues 7

number

Amino Acid Distribution

A: 4 R: 3 N: 2 D: 6 C: 0 E: 3 Q: 0 G: 1 H: 1 I: 4 L: 4 K: 2 M: 0 F: 0 P: 5 S: 1 T: 2 W: 1 Y: 2 V: 1

Length

Formula

C215H334N58O68

Mass

4819.36

4.30

Net Charge

-4

Boman Index

14.50

Hydrophobicity

-0.774

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 11.4-22.7 µM

Target

Target Organism M. luteus

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against gram+ M. luteus (MIC 11.4-22.7 uM), L. monocytogenes (MIC 45.5-90.7 uM), filamentous fungi A. niger (MIC 46.4-90.9 uM) and T

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 45.5-90.7 µM

Target

Target Organism L. monocytogenes

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against gram+ M. luteus (MIC 11.4-22.7 uM), L. monocytogenes (MIC 45.5-90.7 uM), filamentous fungi A. niger (MIC 46.4-90.9 uM) and T. harzianum (MIC 46.4-90.9 uM). Updat

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 46.4-90.9 µM

Target

Target Organism A. niger

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

ram+ M. luteus (MIC 11.4-22.7 uM), L. monocytogenes (MIC 45.5-90.7 uM), filamentous fungi A. niger (MIC 46.4-90.9 uM) and T. harzianum (MIC 46.4-90.9 uM). Updated 3/2020 11/2025

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 46.4-90.9 µM

Target

Target Organism T. harzianum

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

), L. monocytogenes (MIC 45.5-90.7 uM), filamentous fungi A. niger (MIC 46.4-90.9 uM) and T. harzianum (MIC 46.4-90.9 uM). Updated 3/2020 11/2025

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 11.4-22.7 µM

Target

Target Organism M. luteus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against gram+ M. luteus (MIC 11.4-22.7 uM), L. monocytogenes (MIC 45.5-90.7 uM), filamentous fungi A. niger (MIC 46.4-90.9 uM) and T

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 45.5-90.7 µM

Target

Target Organism L. monocytogenes

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against gram+ M. luteus (MIC 11.4-22.7 uM), L. monocytogenes (MIC 45.5-90.7 uM), filamentous fungi A. niger (MIC 46.4-90.9 uM) and T. harzianum (MIC 46.4-90.9 uM). Updat

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 46.4-90.9 µM

Target

Target Organism A. niger

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

ram+ M. luteus (MIC 11.4-22.7 uM), L. monocytogenes (MIC 45.5-90.7 uM), filamentous fungi A. niger (MIC 46.4-90.9 uM) and T. harzianum (MIC 46.4-90.9 uM). Updated 3/2020 11/2025

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 46.4-90.9 µM

Target

Target Organism T. harzianum

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

), L. monocytogenes (MIC 45.5-90.7 uM), filamentous fungi A. niger (MIC 46.4-90.9 uM) and T. harzianum (MIC 46.4-90.9 uM). Updated 3/2020 11/2025

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 11.4-22.7 µM

Target

Target Organism M. luteus

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against gram+ M. luteus (MIC 11.4-22.7 uM), L. monocytogenes (MIC 45.5-90.7 uM), filamentous fungi A. niger (MIC 46.4-90.9 uM) and T

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 45.5-90.7 µM

Target

Target Organism L. monocytogenes

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against gram+ M. luteus (MIC 11.4-22.7 uM), L. monocytogenes (MIC 45.5-90.7 uM), filamentous fungi A. niger (MIC 46.4-90.9 uM) and T. harzianum (MIC 46.4-90.9 uM). Updat

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 46.4-90.9 µM

Target

Target Organism A. niger

Source & Reference

Database Source DRAMP

Other

Evidence Text

ram+ M. luteus (MIC 11.4-22.7 uM), L. monocytogenes (MIC 45.5-90.7 uM), filamentous fungi A. niger (MIC 46.4-90.9 uM) and T. harzianum (MIC 46.4-90.9 uM). Updated 3/2020 11/2025

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 46.4-90.9 µM

Target

Target Organism T. harzianum

Source & Reference

Database Source DRAMP

Other

Evidence Text

), L. monocytogenes (MIC 45.5-90.7 uM), filamentous fungi A. niger (MIC 46.4-90.9 uM) and T. harzianum (MIC 46.4-90.9 uM). Updated 3/2020 11/2025