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Peptide record

TPDB04926

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
31 amino acids
Basic Information
3D PDB MODEL
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TPDB04926
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb dbAMP AI4AVP AVPpred-BWR dbAMP 3.0 DRAMP DRAVP 2.0 APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 31-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AntiCP 2.0, and other sources, with an available 3D structural model.
Sequence
SISCGESCAMISFCFTEVIGCSCKNKVCYLN
Physicochemical Analysis
C140H223N35O45S7
RDQHPW
C
3340.94
6.05
2
2
11
-0
1.28
0.690
72.26
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
1865
55.82
15
Residue Composition
number
1
A
0
R
2
N
0
D
6
C
2
E
0
Q
2
G
0
H
3
I
1
L
2
K
1
M
2
F
0
P
5
S
1
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 1 R: 0 N: 2 D: 0 C: 6 E: 2 Q: 0 G: 2 H: 0 I: 3 L: 1 K: 2 M: 1 F: 2 P: 0 S: 5 T: 1 W: 0 Y: 1 V: 2
Chemical Descriptors
31
C140H223N35O45S7
3340.94
6.05
-0
1.28
0.690
Evidence Records 6 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
It inhibited HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells (EC50 870 nM) (Ireland et al., 2008) .
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
It inhibited HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells (EC50 870 nM) (Ireland et al., 2008) .
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class.
It inhibited HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells (EC50 870 nM) (Ireland et al., 2008) .
Evidence 4 Activity

Activity

Antiviral

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
It inhibited HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells (EC50 870 nM) (Ireland et al., 2008) .
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
55.2±1.5 µM
Hemolytic Cytotoxic
50% Hemolysis | 55.2±1.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structural and biochemical characteristics of the cyclotide kalata B5 from Oldenlandia affinis. | Biopolymers | 2010
Evidence 6 Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.