Back to search

Peptide record

TPDB04901

Phylloseptin-L1 Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard

18 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB04901

Peptide_Name

Phylloseptin-L1

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab AFP-GFuse Antifungipept CAFPdb APD_complete APD_hemolytic Hemolytic2 PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.

Sequence

LLGMIPLAISAISALSKL

FASTA

>TPDB04901|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral;Hemolysis;Toxicity|length=18
LLGMIPLAISAISALSKL

Formula C84H151N19O22S1

Absent Amino Acids RNDCEQHFTWYV

Common Amino Acids L

Mass 1811.30

PI 10.10

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 12

Net Charge +1

Boman Index -2.63

Hydrophobicity 1.750

Aliphatic Index 190.00

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 3

number

Amino Acid Distribution

A: 3 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 3 L: 5 K: 1 M: 1 F: 0 P: 1 S: 3 T: 0 W: 0 Y: 0 V: 0

Length

Formula

C84H151N19O22S1

Mass

1811.30

10.10

Net Charge

Boman Index

-2.63

Hydrophobicity

1.750

C_terminal_Modification

Free

Chirality

Linear_or_Cyclic

Not Available

N_terminal_Modification

Free

Nature

Anticancer

Origin

Hylomantis lemur (Hylidae: Phyllomedusinae

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

Phylloseptin-L1 was active against S. aureus (MIC 8 uM). This peptide also inhibited growth of B. dendrobatidis zoospores at concentrations above

Evidence 2 Activity

Activity

Activity Raw

Not Available

Detail Source Activity Anticancer

Target

Cancer Type Colorectal Cancer

Cell Line Not Available

Tissue Affected Not Available

Assay & Model

Assay Not Available

Testing Time Not Available

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2007

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

Phylloseptin-L1 was active against S. aureus (MIC 8 uM). This peptide also inhibited growth of B. dendrobatidis zoospores at concentrations above

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 8 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source NA

Other

Evidence Text

Phylloseptin-L1 was active against S. aureus (MIC 8 uM). This peptide also inhibited growth of B. dendrobatidis zoospores at concentrations above

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 8 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source NA

Other

Evidence Text

Phylloseptin-L1 was active against S. aureus (MIC 8 uM). This peptide also inhibited growth of B. dendrobatidis zoospores at concentrations above

Evidence 6 Activity

Activity

Activity Endpoint LC50

Detail Source Activity Hemolysis

Activity Measurement 200 µM

Hemolysis Raw

Human erythrocytes: LC50=200 µM

Target

RBC Target Human erythrocytes

Source & Reference

Database Source Hemolytik APD_complete APD_hemolytic PD_Hemolysis

Source DRAMP4

Reference

Toxicon. 2007 Sep 15 50(4):498-506.

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.

Evidence 7 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 40 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 40 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Peptides with differential cytolytic activity from skin secretions of the lemur leaf frog Hylomantis lemur (Hylidae: Phyllomedusinae) | Toxicon | 2007

Evidence 8 Activity

Activity

Activity Endpoint 9% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 32 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

9% Hemolysis | 32 | µg/mL | target cell: Horse erythrocytes

Target

Target Cell Horse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Medusins: a new class of antimicrobial peptides from the skin secretions of phyllomedusine frogs. | Biochimie | 2013

Evidence 9 Activity

Activity

Activity Endpoint LC50

Detail Source Activity Toxicity

Activity Measurement 200 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

Hemolytic_activity: Human erythrocytes: LC50=200 µM | Cytotoxicity: Not available

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Toxicon. 2007 Sep 15 50(4):498-506.

Evidence 10 Hemolysis

Activity

Activity Measurement 200 µM

Activity Endpoint LC50

Hemolysis Raw

Human erythrocytes: LC50=200 µM

Detail Source Activity Hemolysis

Target

RBC Target Human erythrocytes

Source & Reference

source APD_complete APD_hemolytic PD_Hemolysis

Reference

Toxicon. 2007 Sep 15 50(4):498-506.

Source DRAMP4

Database Source APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.