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Peptide record

TPDB04869

Antibacterial Anticancer Antifungal Antiparasitic Antiviral standard

40 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB04869

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

AntiBP3 Peptipedia Antifungipept

Sequence_Type

standard

Has_Modification No

Description A 40-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, and Antifungipept, with an available 3D structural model.

Sequence

GKREKCLRRNGFCAFLKCPTLSVISGTCSRFQVCCKTLLG

FASTA

>TPDB04869|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral|length=40
GKREKCLRRNGFCAFLKCPTLSVISGTCSRFQVCCKTLLG

Formula C190H320N58O51S6

Absent Amino Acids DHMWY

Common Amino Acids C

Mass 4425.35

PI 9.78

Basic Residues 8

Acidic Residues 1

Hydrophobic Residues 12

Net Charge +7

Boman Index 3.55

Hydrophobicity 0.133

Aliphatic Index 75.50

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 375

Absorbance 280nm 8.47

Polar Residues 14

number

Amino Acid Distribution

A: 1 R: 4 N: 1 D: 0 C: 6 E: 1 Q: 1 G: 4 H: 0 I: 1 L: 5 K: 4 M: 0 F: 3 P: 1 S: 3 T: 3 W: 0 Y: 0 V: 2

Length

Formula

C190H320N58O51S6

Mass

4425.35

9.78

Net Charge

Boman Index

3.55

Hydrophobicity

0.133

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source NA

Other

Evidence Text

active against C. albicans (MIC 8 ug/ml), B. avium (MIC 8 ug/ml), E. coli (MIC 8 ug/ml), S. enteriditis (MIC 8 ug/ml), S. typhimur

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µg/mL

Target

Target Organism B. avium

Source & Reference

Database Source NA

Other

Evidence Text

active against C. albicans (MIC 8 ug/ml), B. avium (MIC 8 ug/ml), E. coli (MIC 8 ug/ml), S. enteriditis (MIC 8 ug/ml), S. typhimurium (MIC 4 ug/ml), C. je

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source NA

Other

Evidence Text

active against C. albicans (MIC 8 ug/ml), B. avium (MIC 8 ug/ml), E. coli (MIC 8 ug/ml), S. enteriditis (MIC 8 ug/ml), S. typhimurium (MIC 4 ug/ml), C. jejuni (MIC 2 ug/ml), P-m

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µg/mL

Target

Target Organism S. enteriditis

Source & Reference

Database Source NA

Other

Evidence Text

active against C. albicans (MIC 8 ug/ml), B. avium (MIC 8 ug/ml), E. coli (MIC 8 ug/ml), S. enteriditis (MIC 8 ug/ml), S. typhimurium (MIC 4 ug/ml), C. jejuni (MIC 2 ug/ml), P-multocida (MIC >16 ug/ml), M. g

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µg/mL

Target

Target Organism S. typhimurium

Source & Reference

Database Source NA

Other

Evidence Text

IC 8 ug/ml), B. avium (MIC 8 ug/ml), E. coli (MIC 8 ug/ml), S. enteriditis (MIC 8 ug/ml), S. typhimurium (MIC 4 ug/ml), C. jejuni (MIC 2 ug/ml), P-multocida (MIC >16 ug/ml), M. gallisepticum (MIC 8 ug/ml) ( E

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µg/mL

Target

Target Organism C. jejuni

Source & Reference

Database Source NA

Other

Evidence Text

g/ml), E. coli (MIC 8 ug/ml), S. enteriditis (MIC 8 ug/ml), S. typhimurium (MIC 4 ug/ml), C. jejuni (MIC 2 ug/ml), P-multocida (MIC >16 ug/ml), M. gallisepticum (MIC 8 ug/ml) ( Evans et al., 1995 . THP1

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µg/mL

Target

Target Organism M. gallisepticum

Source & Reference

Database Source NA

Other

Evidence Text

/ml), S. typhimurium (MIC 4 ug/ml), C. jejuni (MIC 2 ug/ml), P-multocida (MIC >16 ug/ml), M. gallisepticum (MIC 8 ug/ml) ( Evans et al., 1995 . THP1 killed S. aureus and E. coli in vitro. Updated 7/2021, Jan202

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source Antifungipept

Other

Evidence Text

active against C. albicans (MIC 8 ug/ml), B. avium (MIC 8 ug/ml), E. coli (MIC 8 ug/ml), S. enteriditis (MIC 8 ug/ml), S. typhimur

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8 µg/mL

Target

Target Organism B. avium

Source & Reference

Database Source Antifungipept

Other

Evidence Text

active against C. albicans (MIC 8 ug/ml), B. avium (MIC 8 ug/ml), E. coli (MIC 8 ug/ml), S. enteriditis (MIC 8 ug/ml), S. typhimurium (MIC 4 ug/ml), C. je

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source Antifungipept

Other

Evidence Text

active against C. albicans (MIC 8 ug/ml), B. avium (MIC 8 ug/ml), E. coli (MIC 8 ug/ml), S. enteriditis (MIC 8 ug/ml), S. typhimurium (MIC 4 ug/ml), C. jejuni (MIC 2 ug/ml), P-m

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8 µg/mL

Target

Target Organism S. enteriditis

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µg/mL

Target

Target Organism S. typhimurium

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µg/mL

Target

Target Organism C. jejuni

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8 µg/mL

Target

Target Organism M. gallisepticum

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 8 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source NA

Other

Evidence Text

active against C. albicans (MIC 8 ug/ml), B. avium (MIC 8 ug/ml), E. coli (MIC 8 ug/ml), S. enteriditis (MIC 8 ug/ml), S. typhimur

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 8 µg/mL

Target

Target Organism B. avium

Source & Reference

Database Source NA

Other

Evidence Text

active against C. albicans (MIC 8 ug/ml), B. avium (MIC 8 ug/ml), E. coli (MIC 8 ug/ml), S. enteriditis (MIC 8 ug/ml), S. typhimurium (MIC 4 ug/ml), C. je

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 8 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source NA

Other

Evidence Text

active against C. albicans (MIC 8 ug/ml), B. avium (MIC 8 ug/ml), E. coli (MIC 8 ug/ml), S. enteriditis (MIC 8 ug/ml), S. typhimurium (MIC 4 ug/ml), C. jejuni (MIC 2 ug/ml), P-m

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 8 µg/mL

Target

Target Organism S. enteriditis

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 4 µg/mL

Target

Target Organism S. typhimurium

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 2 µg/mL

Target

Target Organism C. jejuni

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 8 µg/mL

Target

Target Organism M. gallisepticum

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 8 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source NA

Other

Evidence Text

active against C. albicans (MIC 8 ug/ml), B. avium (MIC 8 ug/ml), E. coli (MIC 8 ug/ml), S. enteriditis (MIC 8 ug/ml), S. typhimur

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 8 µg/mL

Target

Target Organism B. avium

Source & Reference

Database Source NA

Other

Evidence Text

active against C. albicans (MIC 8 ug/ml), B. avium (MIC 8 ug/ml), E. coli (MIC 8 ug/ml), S. enteriditis (MIC 8 ug/ml), S. typhimurium (MIC 4 ug/ml), C. je

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 8 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source NA

Other

Evidence Text

active against C. albicans (MIC 8 ug/ml), B. avium (MIC 8 ug/ml), E. coli (MIC 8 ug/ml), S. enteriditis (MIC 8 ug/ml), S. typhimurium (MIC 4 ug/ml), C. jejuni (MIC 2 ug/ml), P-m

Evidence 25 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 8 µg/mL

Target

Target Organism S. enteriditis

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 26 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 4 µg/mL

Target

Target Organism S. typhimurium

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 27 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 2 µg/mL

Target

Target Organism C. jejuni

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 28 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 8 µg/mL

Target

Target Organism M. gallisepticum

Source & Reference

Database Source NA

Other

Evidence Text