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Peptide record

TPDB04826

Antibacterial Anticancer Antifungal Antiparasitic Antiviral standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB04826
Antibacterial Anticancer Antifungal Antiparasitic Antiviral
Anti-infective peptides Cancer-related peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF Antifungipept
standard
No
A 28-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
CAWYNISCRLGNKGAYCTLTVECMPSCN
Physicochemical Analysis
C130H202N36O40S6
DQHF
C
3101.61
7.72
2
1
10
+1
-0.77
0.107
59.29
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
8730
281.47
14
Residue Composition
number
2
A
1
R
3
N
0
D
5
C
1
E
0
Q
2
G
0
H
1
I
2
L
1
K
1
M
0
F
1
P
2
S
2
T
1
W
2
Y
1
V
Amino Acid Distribution
A: 2 R: 1 N: 3 D: 0 C: 5 E: 1 Q: 0 G: 2 H: 0 I: 1 L: 2 K: 1 M: 1 F: 0 P: 1 S: 2 T: 2 W: 1 Y: 2 V: 1
Chemical Descriptors
28
C130H202N36O40S6
3101.61
7.72
+1
-0.77
0.107
Evidence Records 4 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against L. lactis strains HP, AM2, 104, 497, MG1363), L. monocytogenes L028, L. innocua EL, E. faecium DPC1146, E. faecium DPC3675, E. faecalis EL, E. coli EC101 and DH5alpha, S. mutans 257, P. pentosacaeus ATCC43200, L. bulgaricusEL, B. cereus Els based on zone diffusion assays (4.5-13 mm). Haloduracin A1 binds the peptidoglycan precursor lipid II with 2:1 stoichiometry (Oman T et al., 2011) . This mediates pore formation by the complex including HalA2, leading to K+ efflux ( Oman TJ et al 2009 ACS Chem Biol 4:865-874). UPdated Jan2016, 4/2024.
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against L. lactis strains HP, AM2, 104, 497, MG1363), L. monocytogenes L028, L. innocua EL, E. faecium DPC1146, E. faecium DPC3675, E. faecalis EL, E. coli EC101 and DH5alpha, S. mutans 257, P. pentosacaeus ATCC43200, L. bulgaricusEL, B. cereus Els based on zone diffusion assays (4.5-13 mm). Haloduracin A1 binds the peptidoglycan precursor lipid II with 2:1 stoichiometry (Oman T et al., 2011) . This mediates pore formation by the complex including HalA2, leading to K+ efflux ( Oman TJ et al 2009 ACS Chem Biol 4:865-874). UPdated Jan2016, 4/2024.
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

DRAMP

Other

Active against L. lactis strains HP, AM2, 104, 497, MG1363), L. monocytogenes L028, L. innocua EL, E. faecium DPC1146, E. faecium DPC3675, E. faecalis EL, E. coli EC101 and DH5alpha, S. mutans 257, P. pentosacaeus ATCC43200, L. bulgaricusEL, B. cereus Els based on zone diffusion assays (4.5-13 mm). Haloduracin A1 binds the peptidoglycan precursor lipid II with 2:1 stoichiometry (Oman T et al., 2011) . This mediates pore formation by the complex including HalA2, leading to K+ efflux ( Oman TJ et al 2009 ACS Chem Biol 4:865-874). UPdated Jan2016, 4/2024.
Evidence 4 Activity

Activity

Antiviral

Source & Reference

DRAMP

Other

Active against L. lactis strains HP, AM2, 104, 497, MG1363), L. monocytogenes L028, L. innocua EL, E. faecium DPC1146, E. faecium DPC3675, E. faecalis EL, E. coli EC101 and DH5alpha, S. mutans 257, P. pentosacaeus ATCC43200, L. bulgaricusEL, B. cereus Els based on zone diffusion assays (4.5-13 mm). Haloduracin A1 binds the peptidoglycan precursor lipid II with 2:1 stoichiometry (Oman T et al., 2011) . This mediates pore formation by the complex including HalA2, leading to K+ efflux ( Oman TJ et al 2009 ACS Chem Biol 4:865-874). UPdated Jan2016, 4/2024.