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Peptide record

TPDB04819

Antibacterial Antifungal Toxicity standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB04819
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb DRAMP dbAMP ToxinPred 3.0
standard
No
A 26-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
FFGTLFKLGSKLIPGVMKLFSKKKER
Physicochemical Analysis
C144H235N35O32S1
ANDCQHWY
K
3000.73
11.19
7
1
11
+6
2.42
0.019
86.15
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
3
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
1
E
0
Q
3
G
0
H
1
I
4
L
6
K
1
M
4
F
1
P
2
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 3 H: 0 I: 1 L: 4 K: 6 M: 1 F: 4 P: 1 S: 2 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
26
C144H235N35O32S1
3000.73
11.19
+6
2.42
0.019
Evidence Records 14 records
Evidence 1 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

Candida albicans SC5314

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
DRAMP antibacterial activity supported by MIC records against bacterial target organisms. dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against C. albicans SC5314 (MIC 12.5 uM), C. tropicalis ATCC 750 (MIC 3.12 uM), C. parapsilosis ATCC 22019 (MIC 50 uM), C. glabrat
Evidence 2 Activity

Activity

MIC
Antibacterial
3.12 µM

Target

C. tropicalis ATCC 750

Source & Reference

dbAMP DRAMP

Other

Active against C. albicans SC5314 (MIC 12.5 uM), C. tropicalis ATCC 750 (MIC 3.12 uM), C. parapsilosis ATCC 22019 (MIC 50 uM), C. glabrata ATCC 90030 (MIC 200 uM), C. neoforma
Evidence 3 Activity

Activity

MIC
Antibacterial
50 µM

Target

C. parapsilosis ATCC 22019

Source & Reference

dbAMP DRAMP

Other

Active against C. albicans SC5314 (MIC 12.5 uM), C. tropicalis ATCC 750 (MIC 3.12 uM), C. parapsilosis ATCC 22019 (MIC 50 uM), C. glabrata ATCC 90030 (MIC 200 uM), C. neoformans H99 serotype A (MIC 12.5 uM), and C.
Evidence 4 Activity

Activity

MIC
Antibacterial
200 µM

Target

C. glabrata ATCC 90030

Source & Reference

dbAMP DRAMP

Other

C 12.5 uM), C. tropicalis ATCC 750 (MIC 3.12 uM), C. parapsilosis ATCC 22019 (MIC 50 uM), C. glabrata ATCC 90030 (MIC 200 uM), C. neoformans H99 serotype A (MIC 12.5 uM), and C. neoformans B3501 serotype D (MIC 6.25
Evidence 5 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

C. neoformans H99 serotype A

Source & Reference

dbAMP DRAMP

Other

IC 3.12 uM), C. parapsilosis ATCC 22019 (MIC 50 uM), C. glabrata ATCC 90030 (MIC 200 uM), C. neoformans H99 serotype A (MIC 12.5 uM), and C. neoformans B3501 serotype D (MIC 6.25 uM). It also showed antibiofilmF activity a
Evidence 6 Activity

Activity

MIC
Antibacterial
6.25 µM

Target

C. neoformans B3501 serotype D

Source & Reference

dbAMP DRAMP

Other

uM), C. glabrata ATCC 90030 (MIC 200 uM), C. neoformans H99 serotype A (MIC 12.5 uM), and C. neoformans B3501 serotype D (MIC 6.25 uM). It also showed antibiofilmF activity against initial adherence of C. albicans at 25 uM b
Evidence 7 Activity

Activity

MIC
Antifungal
12.5 µM

Target

Candida albicans SC5314

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
DRAMP antifungal activity supported by activity records against fungal target organisms. dbAMP classified under the Anti-fungal function class.
Active against C. albicans SC5314 (MIC 12.5 uM), C. tropicalis ATCC 750 (MIC 3.12 uM), C. parapsilosis ATCC 22019 (MIC 50 uM), C. glabrat
Evidence 8 Activity

Activity

MIC
Antifungal
3.12 µM

Target

C. tropicalis ATCC 750

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against C. albicans SC5314 (MIC 12.5 uM), C. tropicalis ATCC 750 (MIC 3.12 uM), C. parapsilosis ATCC 22019 (MIC 50 uM), C. glabrata ATCC 90030 (MIC 200 uM), C. neoforma
Evidence 9 Activity

Activity

MIC
Antifungal
50 µM

Target

C. parapsilosis ATCC 22019

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against C. albicans SC5314 (MIC 12.5 uM), C. tropicalis ATCC 750 (MIC 3.12 uM), C. parapsilosis ATCC 22019 (MIC 50 uM), C. glabrata ATCC 90030 (MIC 200 uM), C. neoformans H99 serotype A (MIC 12.5 uM), and C.
Evidence 10 Activity

Activity

MIC
Antifungal
200 µM

Target

C. glabrata ATCC 90030

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

C 12.5 uM), C. tropicalis ATCC 750 (MIC 3.12 uM), C. parapsilosis ATCC 22019 (MIC 50 uM), C. glabrata ATCC 90030 (MIC 200 uM), C. neoformans H99 serotype A (MIC 12.5 uM), and C. neoformans B3501 serotype D (MIC 6.25
Evidence 11 Activity

Activity

MIC
Antifungal
12.5 µM

Target

C. neoformans H99 serotype A

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

IC 3.12 uM), C. parapsilosis ATCC 22019 (MIC 50 uM), C. glabrata ATCC 90030 (MIC 200 uM), C. neoformans H99 serotype A (MIC 12.5 uM), and C. neoformans B3501 serotype D (MIC 6.25 uM). It also showed antibiofilmF activity a
Evidence 12 Activity

Activity

MIC
Antifungal
6.25 µM

Target

C. neoformans B3501 serotype D

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

uM), C. glabrata ATCC 90030 (MIC 200 uM), C. neoformans H99 serotype A (MIC 12.5 uM), and C. neoformans B3501 serotype D (MIC 6.25 uM). It also showed antibiofilmF activity against initial adherence of C. albicans at 25 uM b
Evidence 13 Activity

Activity

48% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
48% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Activity of Scorpion Venom-Derived Antifungal Peptides against Planktonic Cells of Candida spp. and Cryptococcus neoformans and Candida albicans Biofilms. | Front Microbiol | 2016
Evidence 14 Activity

Activity

% Hemolysis
Toxicity
30 %
Hemolytic
Hemolytic_activity: [Ref.27917162] 30% hemolysis at 1.58 µM, 37% hemolysis at 3.16 µM, 45% hemolysis at 6.31 µM, 46% hemolysis at 12.59 µM, 48% hemolysis at 25.12 µM, 47% hemolysis at 50.11 µM , 50% hemolysis at 100µM against human red blood cell

Target

erythrocytes

Source & Reference

NA
DRAMP
Front Microbiol. 2016 Nov 18 7:1844. eCollection 2016.