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Peptide record

TPDB04813

Antibacterial Anticancer Antifungal Antiparasitic standard

24 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB04813

Activity

Antibacterial Anticancer Antifungal Antiparasitic

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept

Sequence_Type

standard

Has_Modification No

Description A 24-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

GNGVLKTISHECNMNTWQFLFTCC

FASTA

>TPDB04813|Antibacterial;Anticancer;Antifungal;Antiparasitic|length=24
GNGVLKTISHECNMNTWQFLFTCC

Formula C119H180N32O35S4

Absent Amino Acids ARDPY

Common Amino Acids NCT

Mass 2747.17

PI 6.91

Basic Residues 2

Acidic Residues 1

Hydrophobic Residues 8

Net Charge -0

Boman Index -0.04

Hydrophobicity 0.087

Aliphatic Index 60.83

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 5625

Absorbance 280nm 204.76

Polar Residues 11

number

Amino Acid Distribution

A: 0 R: 0 N: 3 D: 0 C: 3 E: 1 Q: 1 G: 2 H: 1 I: 1 L: 2 K: 1 M: 1 F: 2 P: 0 S: 1 T: 3 W: 1 Y: 0 V: 1

Length

Formula

C119H180N32O35S4

Mass

2747.17

6.91

Net Charge

-0

Boman Index

-0.04

Hydrophobicity

0.087

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 75 UG/ML

Target

Target Organism B. longum ATCC 15707

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against B. longum ATCC 15707 (MIC 75 UG/ML), E. contortum ATCC 25540 (MIC 32.5 UG/ML), R. obeum ATCC 29174 (MIC 32.5 ug/ml), R. gnavu

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 32.5 UG/ML

Target

Target Organism E. contortum ATCC 25540

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against B. longum ATCC 15707 (MIC 75 UG/ML), E. contortum ATCC 25540 (MIC 32.5 UG/ML), R. obeum ATCC 29174 (MIC 32.5 ug/ml), R. gnavus ATCC 29149 (MIC 75 ug/ml), C. perfringen

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 32.5 µg/mL

Target

Target Organism R. obeum ATCC 29174

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

ve against B. longum ATCC 15707 (MIC 75 UG/ML), E. contortum ATCC 25540 (MIC 32.5 UG/ML), R. obeum ATCC 29174 (MIC 32.5 ug/ml), R. gnavus ATCC 29149 (MIC 75 ug/ml), C. perfringens CpA (MIC 75 UG/ML), C. difficile ser

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 75 µg/mL

Target

Target Organism R. gnavus ATCC 29149

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

5 UG/ML), E. contortum ATCC 25540 (MIC 32.5 UG/ML), R. obeum ATCC 29174 (MIC 32.5 ug/ml), R. gnavus ATCC 29149 (MIC 75 ug/ml), C. perfringens CpA (MIC 75 UG/ML), C. difficile serogroup A B-1 (MIC 75 UG/ML), C. diffi

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 75 UG/ML

Target

Target Organism Clostridium perfringens CpA

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

C 32.5 UG/ML), R. obeum ATCC 29174 (MIC 32.5 ug/ml), R. gnavus ATCC 29149 (MIC 75 ug/ml), C. perfringens CpA (MIC 75 UG/ML), C. difficile serogroup A B-1 (MIC 75 UG/ML), C. difficile serogroup C C253 (MIC 75 UG/ML

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 75 UG/ML

Target

Target Organism Clostridioides difficile serogroup A B-1

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

(MIC 32.5 ug/ml), R. gnavus ATCC 29149 (MIC 75 ug/ml), C. perfringens CpA (MIC 75 UG/ML), C. difficile serogroup A B-1 (MIC 75 UG/ML), C. difficile serogroup C C253 (MIC 75 UG/ML), C. difficile serogroup S3 (MIC 75 UG/ML),

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 75 UG/ML

Target

Target Organism Clostridioides difficile serogroup C C253

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

5 ug/ml), C. perfringens CpA (MIC 75 UG/ML), C. difficile serogroup A B-1 (MIC 75 UG/ML), C. difficile serogroup C C253 (MIC 75 UG/ML), C. difficile serogroup S3 (MIC 75 UG/ML), C. botulinum (MIC 75 UG/ML), C. bifermentans (

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 75 UG/ML

Target

Target Organism Clostridioides difficile serogroup S3

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

. difficile serogroup A B-1 (MIC 75 UG/ML), C. difficile serogroup C C253 (MIC 75 UG/ML), C. difficile serogroup S3 (MIC 75 UG/ML), C. botulinum (MIC 75 UG/ML), C. bifermentans (MIC 75 UG/ML), and B. cereus Z4222(MIC 75

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 75 UG/ML

Target

Target Organism C. botulinum

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

, C. difficile serogroup C C253 (MIC 75 UG/ML), C. difficile serogroup S3 (MIC 75 UG/ML), C. botulinum (MIC 75 UG/ML), C. bifermentans (MIC 75 UG/ML), and B. cereus Z4222(MIC 75 UG/ML), TZ415 (mic 75 ug/ml).

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 75 UG/ML

Target

Target Organism C. bifermentans

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

53 (MIC 75 UG/ML), C. difficile serogroup S3 (MIC 75 UG/ML), C. botulinum (MIC 75 UG/ML), C. bifermentans (MIC 75 UG/ML), and B. cereus Z4222(MIC 75 UG/ML), TZ415 (mic 75 ug/ml). Updated 7/2021

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 75 UG/ML

Target

Target Organism B. cereus Z4222

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

group S3 (MIC 75 UG/ML), C. botulinum (MIC 75 UG/ML), C. bifermentans (MIC 75 UG/ML), and B. cereus Z4222(MIC 75 UG/ML), TZ415 (mic 75 ug/ml). Updated 7/2021

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 75 UG/ML

Target

Target Organism B. longum ATCC 15707

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against B. longum ATCC 15707 (MIC 75 UG/ML), E. contortum ATCC 25540 (MIC 32.5 UG/ML), R. obeum ATCC 29174 (MIC 32.5 ug/ml), R. gnavu

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 32.5 UG/ML

Target

Target Organism E. contortum ATCC 25540

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Active against B. longum ATCC 15707 (MIC 75 UG/ML), E. contortum ATCC 25540 (MIC 32.5 UG/ML), R. obeum ATCC 29174 (MIC 32.5 ug/ml), R. gnavus ATCC 29149 (MIC 75 ug/ml), C. perfringen

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 32.5 µg/mL

Target

Target Organism R. obeum ATCC 29174

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 75 µg/mL

Target

Target Organism R. gnavus ATCC 29149

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 75 UG/ML

Target

Target Organism Clostridium perfringens CpA

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 75 UG/ML

Target

Target Organism Clostridioides difficile serogroup A B-1

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 75 UG/ML

Target

Target Organism Clostridioides difficile serogroup C C253

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 75 UG/ML

Target

Target Organism Clostridioides difficile serogroup S3

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 75 UG/ML

Target

Target Organism C. botulinum

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 75 UG/ML

Target

Target Organism C. bifermentans

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

53 (MIC 75 UG/ML), C. difficile serogroup S3 (MIC 75 UG/ML), C. botulinum (MIC 75 UG/ML), C. bifermentans (MIC 75 UG/ML), and B. cereus Z4222(MIC 75 UG/ML), TZ415 (mic 75 ug/ml). Updated 7/2021

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 75 UG/ML

Target

Target Organism B. cereus Z4222

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

group S3 (MIC 75 UG/ML), C. botulinum (MIC 75 UG/ML), C. bifermentans (MIC 75 UG/ML), and B. cereus Z4222(MIC 75 UG/ML), TZ415 (mic 75 ug/ml). Updated 7/2021

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 75 UG/ML

Target

Target Organism B. longum ATCC 15707

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against B. longum ATCC 15707 (MIC 75 UG/ML), E. contortum ATCC 25540 (MIC 32.5 UG/ML), R. obeum ATCC 29174 (MIC 32.5 ug/ml), R. gnavu

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 32.5 UG/ML

Target

Target Organism E. contortum ATCC 25540

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against B. longum ATCC 15707 (MIC 75 UG/ML), E. contortum ATCC 25540 (MIC 32.5 UG/ML), R. obeum ATCC 29174 (MIC 32.5 ug/ml), R. gnavus ATCC 29149 (MIC 75 ug/ml), C. perfringen

Evidence 25 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 32.5 µg/mL

Target

Target Organism R. obeum ATCC 29174

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 26 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 75 µg/mL

Target

Target Organism R. gnavus ATCC 29149

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 27 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 75 UG/ML

Target

Target Organism Clostridium perfringens CpA

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 28 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 75 UG/ML

Target

Target Organism Clostridioides difficile serogroup A B-1

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 29 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 75 UG/ML

Target

Target Organism Clostridioides difficile serogroup C C253

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 30 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 75 UG/ML

Target

Target Organism Clostridioides difficile serogroup S3

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 31 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 75 UG/ML

Target

Target Organism C. botulinum

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 32 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 75 UG/ML

Target

Target Organism C. bifermentans

Source & Reference

Database Source DRAMP

Other

Evidence Text

53 (MIC 75 UG/ML), C. difficile serogroup S3 (MIC 75 UG/ML), C. botulinum (MIC 75 UG/ML), C. bifermentans (MIC 75 UG/ML), and B. cereus Z4222(MIC 75 UG/ML), TZ415 (mic 75 ug/ml). Updated 7/2021

Evidence 33 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 75 UG/ML

Target

Target Organism B. cereus Z4222

Source & Reference

Database Source DRAMP

Other

Evidence Text

group S3 (MIC 75 UG/ML), C. botulinum (MIC 75 UG/ML), C. bifermentans (MIC 75 UG/ML), and B. cereus Z4222(MIC 75 UG/ML), TZ415 (mic 75 ug/ml). Updated 7/2021