TPDB

3D PDB MODEL

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TPDB ID TPDB04812

Activity

Antibacterial Antifungal

Activity_category_statistics

Anti-infective peptides

Database_Source

AntiBP3 Peptipedia Antifungipept

Sequence_Type

standard

Has_Modification No

Description A 23-aa standard natural multi-activity (Antibacterial and Antifungal) peptide sequence curated from AntiBP3, Peptipedia, and Antifungipept, with an available 3D structural model.

Sequence

FLKGVINLASKIPSMLCAVLKTC

FASTA

>TPDB04812|Antibacterial;Antifungal|length=23
FLKGVINLASKIPSMLCAVLKTC

Formula C111H193N27O28S3

Absent Amino Acids RDEQHWY

Common Amino Acids L

Mass 2450.10

PI 9.80

Basic Residues 3

Acidic Residues 0

Hydrophobic Residues 12

Net Charge +3

Boman Index -0.65

Hydrophobicity 1.148

Aliphatic Index 135.65

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 125

Absorbance 280nm 5.10

Polar Residues 6

number

2

A

0

R

1

N

0

D

2

C

0

E

0

Q

1

G

0

H

2

I

4

L

3

K

1

M

1

F

1

P

2

S

1

T

0

W

0

Y

2

V

Amino Acid Distribution

A: 2 R: 0 N: 1 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 4 K: 3 M: 1 F: 1 P: 1 S: 2 T: 1 W: 0 Y: 0 V: 2

Length

23

Formula

C111H193N27O28S3

Mass

2450.10

PI

9.80

Net Charge

+3

Boman Index

-0.65

Hydrophobicity

1.148

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 19 µM

Target

Target Organism Staphylococcus aureus ATCC25923

Source & Reference

Database Source NA

Other

Evidence Text

st Gram+ bacteria E. faecium 091299 (IS) (MIC 75 uM), E. faecalis 981 (IS) (MIC 37.5 uM), S. aureus ATCC25923 (MIC 19 uM), S. carnosus KHS (IS) (MIC 37.5 uM), B. licheniformis X39 (IS) (MIC 19 uM), R. rhodochrou

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 75 µM

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source NA

Other

Evidence Text

.5 uM), B. licheniformis X39 (IS) (MIC 19 uM), R. rhodochrous X15 (IS)(MIC 4.8 uM), Gram- E. coli ATCC25922 (MIC 75 uM), S.typhi 091408 (IS)(MIC >150 uM), P.aeruginosa (ATCC27853) (MIC >150 uM), P.aeruginosa (

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >150 µM

Target

Target Organism C.albicans ATCC10231

Source & Reference

Database Source NA

Other

Evidence Text

M), P.aeruginosa (ATCC27853) (MIC >150 uM), P. faecalis X29 (IS) (MIC 37.5 uM), and fungi C.albicans ATCC10231 (MIC>150 uM).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 19 µM

Target

Target Organism Staphylococcus aureus ATCC25923

Source & Reference

Database Source Antifungipept

Other

Evidence Text

st Gram+ bacteria E. faecium 091299 (IS) (MIC 75 uM), E. faecalis 981 (IS) (MIC 37.5 uM), S. aureus ATCC25923 (MIC 19 uM), S. carnosus KHS (IS) (MIC 37.5 uM), B. licheniformis X39 (IS) (MIC 19 uM), R. rhodochrou

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 75 µM

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source Antifungipept

Other

Evidence Text

.5 uM), B. licheniformis X39 (IS) (MIC 19 uM), R. rhodochrous X15 (IS)(MIC 4.8 uM), Gram- E. coli ATCC25922 (MIC 75 uM), S.typhi 091408 (IS)(MIC >150 uM), P.aeruginosa (ATCC27853) (MIC >150 uM), P.aeruginosa (

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >150 µM

Target

Target Organism C.albicans ATCC10231

Source & Reference

Database Source Antifungipept

Other

Evidence Text

M), P.aeruginosa (ATCC27853) (MIC >150 uM), P. faecalis X29 (IS) (MIC 37.5 uM), and fungi C.albicans ATCC10231 (MIC>150 uM).