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Peptide record

TPDB04780

Antibacterial Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB04780
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 18-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
YIRKIRRFFKTLNKNLKK
Physicochemical Analysis
C111H188N34O23
ADCEQGHMPSWV
K
2366.93
12.17
8
0
7
+8
3.42
-1.100
86.67
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
62.95
4
Residue Composition
number
0
A
3
R
2
N
0
D
0
C
0
E
0
Q
0
G
0
H
2
I
2
L
5
K
0
M
2
F
0
P
0
S
1
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 2 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 2 K: 5 M: 0 F: 2 P: 0 S: 0 T: 1 W: 0 Y: 1 V: 0
Chemical Descriptors
18
C111H188N34O23
2366.93
12.17
+8
3.42
-1.100
Evidence Records 2 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
>640 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | >640 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Two optimized antimicrobial peptides with therapeutic potential for clinical antibiotic-resistant Staphylococcus aureus. | Eur J Med Chem | 2019
Evidence 2 Activity

Activity

20% Killing
Toxicity
640 µg/mL
Cytotoxic
20% Killing | 640 | µg/mL | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Two optimized antimicrobial peptides with therapeutic potential for clinical antibiotic-resistant Staphylococcus aureus. | Eur J Med Chem | 2019