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Peptide record

TPDB04769

Antibacterial Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB04769
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 15-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
VKRWKKWWRKWKKWV
Physicochemical Analysis
C113H166N32O16
ANDCEQGHILMFPSTY
K
2228.77
12.46
8
0
7
+8
-1.55
-1.900
38.67
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
27500
1233.87
0
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
6
K
0
M
0
F
0
P
0
S
0
T
5
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 5 Y: 0 V: 2
Chemical Descriptors
15
C113H166N32O16
2228.77
12.46
+8
-1.55
-1.900
Evidence Records 8 records
Evidence 1 Activity

Activity

MIC
Antibacterial
31.0 µg/mL

Target

Escherichia coli

Source & Reference

NA

Other

Active against E. coli (MIC 31.0 ug/ml), P. aeruginosa (MIC 8.0 ug/ml), K. pneumonia (MIC 16.0 ug/ml), E. faecium (MIC 4.0 ug/ml)
Evidence 2 Activity

Activity

MIC
Antibacterial
8.0 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

NA

Other

Active against E. coli (MIC 31.0 ug/ml), P. aeruginosa (MIC 8.0 ug/ml), K. pneumonia (MIC 16.0 ug/ml), E. faecium (MIC 4.0 ug/ml), S. aureus (MIC 2.0 ug/ml), an
Evidence 3 Activity

Activity

MIC
Antibacterial
16.0 µg/mL

Target

K. pneumonia

Source & Reference

NA

Other

Active against E. coli (MIC 31.0 ug/ml), P. aeruginosa (MIC 8.0 ug/ml), K. pneumonia (MIC 16.0 ug/ml), E. faecium (MIC 4.0 ug/ml), S. aureus (MIC 2.0 ug/ml), and C. acnes (MIC 8.0 ug/ml).
Evidence 4 Activity

Activity

MIC
Antibacterial
4.0 µg/mL

Target

E. faecium

Source & Reference

NA

Other

t E. coli (MIC 31.0 ug/ml), P. aeruginosa (MIC 8.0 ug/ml), K. pneumonia (MIC 16.0 ug/ml), E. faecium (MIC 4.0 ug/ml), S. aureus (MIC 2.0 ug/ml), and C. acnes (MIC 8.0 ug/ml).
Evidence 5 Activity

Activity

MIC
Antibacterial
2.0 µg/mL

Target

Staphylococcus aureus

Source & Reference

NA

Other

P. aeruginosa (MIC 8.0 ug/ml), K. pneumonia (MIC 16.0 ug/ml), E. faecium (MIC 4.0 ug/ml), S. aureus (MIC 2.0 ug/ml), and C. acnes (MIC 8.0 ug/ml).
Evidence 6 Activity

Activity

MIC
Antibacterial
8.0 µg/mL

Target

C. acnes

Source & Reference

NA

Other

K. pneumonia (MIC 16.0 ug/ml), E. faecium (MIC 4.0 ug/ml), S. aureus (MIC 2.0 ug/ml), and C. acnes (MIC 8.0 ug/ml).
Evidence 7 Activity

Activity

<5.6% Cytotoxicity
Toxicity
100 µg/mL
Cytotoxic
<5.6% Cytotoxicity | 100 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
A small peptide with therapeutic potential for inflammatory acne vulgaris. | PLoS One | 2013
Evidence 8 Activity

Activity

<5.2% Hemolysis
Toxicity
320 µg/mL
Hemolytic Cytotoxic
<5.2% Hemolysis | 320 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A small peptide with therapeutic potential for inflammatory acne vulgaris. | PLoS One | 2013