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Peptide record

TPDB04766

Antibacterial Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB04766
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 15-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RRYGTCIYQGRLWAF
Physicochemical Analysis
C87H128N26O20S1
NDEHKMPSV
R
1890.20
10.25
3
0
7
+3
-2.97
-0.440
58.67
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
8480
448.63
5
Residue Composition
number
1
A
3
R
0
N
0
D
1
C
0
E
1
Q
2
G
0
H
1
I
1
L
0
K
0
M
1
F
0
P
0
S
1
T
1
W
2
Y
0
V
Amino Acid Distribution
A: 1 R: 3 N: 0 D: 0 C: 1 E: 0 Q: 1 G: 2 H: 0 I: 1 L: 1 K: 0 M: 0 F: 1 P: 0 S: 0 T: 1 W: 1 Y: 2 V: 0
Chemical Descriptors
15
C87H128N26O20S1
1890.20
10.25
+3
-2.97
-0.440
Evidence Records 3 records
Evidence 1 Activity

Activity

25% Killing
Toxicity
100 µg/mL
Cytotoxic
25% Killing | 100 | µg/mL | target cell: Human monocyte-derived macrophages

Target

Human monocyte-derived macrophages

Source & Reference

NA
DBAASP
Exploiting chitosan and gold nanoparticles for antimycobacterial activity of in silico identified antimicrobial motif of human neutrophil peptide-1. | Sci Rep | 2019
Evidence 2 Activity

Activity

7% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
7% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Exploiting chitosan and gold nanoparticles for antimycobacterial activity of in silico identified antimicrobial motif of human neutrophil peptide-1. | Sci Rep | 2019
Evidence 3 Activity

Activity

% Hemolysis
Toxicity
2.7 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.31133658] 2.7% hemolysis at 1µg/ml, 5% hemolysis at 5µg/ml, 6% hemolysis at 50µg/ml, 8% hemolysis at 100 µg/ml against human blood cells. | Cytotoxicity: [Ref.31133658] The cell viability of MDMs induced by Pep-H is 94.2%, 91.5%, 90.4%, 88.0% and 84.1% at peptide concentrations of 1, 5, 25, 50, 100 µg/mL

Target

erythrocytes

Source & Reference

NA
DRAMP
Sci Rep. 2019 9: 7866. Published online 2019 May 27. doi: 10.1038/s41598-019-44256-6