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Peptide record

TPDB04764

Antibacterial Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB04764
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 DRAMP Peptipedia
standard
No
A 15-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, DRAMP, and Peptipedia, with an available 3D structural model.
Sequence
LRCMCIKWWSGKHPK
Physicochemical Analysis
C85H133N25O17S3
ANDEQFTYV
K
1873.33
10.32
5
0
5
+4
0.05
-0.587
52.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
11125
593.86
3
Residue Composition
number
0
A
1
R
0
N
0
D
2
C
0
E
0
Q
1
G
1
H
1
I
1
L
3
K
1
M
0
F
1
P
1
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 1 I: 1 L: 1 K: 3 M: 1 F: 0 P: 1 S: 1 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
15
C85H133N25O17S3
1873.33
10.32
+4
0.05
-0.587
Evidence Records 2 records
Evidence 1 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human dermal fibroblasts

Target

Human dermal fibroblasts

Source & Reference

NA
DBAASP
Thrombocidin-1-derived antimicrobial peptide TC19 combats superficial multi-drug resistant bacterial wound infections. | Biochim Biophys Acta | 2020
Evidence 2 Activity

Activity

Toxicity
Cytotoxic
Cytotoxicity: [Ref.32891601]Up to 40 µM TC19 did not permeabilize human fibroblasts, whereas at 80 µM an increase in PI-positivity was recorded after 4 h of exposure. After 4h of incubation with TC19 at indicated concentration (80 µM), PI-uptake by normal human dermal fibroblasts (NHDF) had increased from 5% to 20% comparing to the result after 1h of incubation.

Source & Reference

NA
DRAMP
Biochim Biophys Acta Biomembr. 2020 Aug 1 1862(8):183282. doi: 10.1016/j.bbamem.2020.183282. Epub 2020 May 3.