TPDB

3D PDB MODEL

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TPDB ID TPDB04708

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia Antifungipept

Sequence_Type

standard

Has_Modification No

Description A 50-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

EYHLMNGANGYLTRVNGKTVYRVTKDPVSAVFGVISNCWGSAGAGFGPQH

FASTA

>TPDB04708|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral|length=50
EYHLMNGANGYLTRVNGKTVYRVTKDPVSAVFGVISNCWGSAGAGFGPQH

Formula C237H358N68O69S2

Absent Amino Acids

Common Amino Acids G

Mass 5327.98

PI 9.43

Basic Residues 6

Acidic Residues 2

Hydrophobic Residues 20

Net Charge +2

Boman Index 3.73

Hydrophobicity -0.178

Aliphatic Index 66.20

Half Life

Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 9970

Absorbance 280nm 187.13

Polar Residues 15

number

4

A

2

R

4

N

1

D

1

C

1

E

1

Q

8

G

2

H

1

I

2

L

2

K

1

M

2

F

2

P

3

S

3

T

1

W

3

Y

6

V

Amino Acid Distribution

A: 4 R: 2 N: 4 D: 1 C: 1 E: 1 Q: 1 G: 8 H: 2 I: 1 L: 2 K: 2 M: 1 F: 2 P: 2 S: 3 T: 3 W: 1 Y: 3 V: 6

Length

50

Formula

C237H358N68O69S2

Mass

5327.98

PI

9.43

Net Charge

+2

Boman Index

3.73

Hydrophobicity

-0.178

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.1-1.6 µM

Target

Target Organism L. ivanovii DMST 9012

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

15, L. garvieae strains, E. faecium D48S52, L. plantarum BCC 9546, L. sakei JCM 1157, and L. ivanovii DMST 9012 (MIC 0.1-1.6 uM).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.1-1.6 µM

Target

Target Organism L. ivanovii DMST 9012

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

15, L. garvieae strains, E. faecium D48S52, L. plantarum BCC 9546, L. sakei JCM 1157, and L. ivanovii DMST 9012 (MIC 0.1-1.6 uM).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 0.1-1.6 µM

Target

Target Organism L. ivanovii DMST 9012

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

15, L. garvieae strains, E. faecium D48S52, L. plantarum BCC 9546, L. sakei JCM 1157, and L. ivanovii DMST 9012 (MIC 0.1-1.6 uM).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 0.1-1.6 µM

Target

Target Organism L. ivanovii DMST 9012

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets.

Evidence Text

15, L. garvieae strains, E. faecium D48S52, L. plantarum BCC 9546, L. sakei JCM 1157, and L. ivanovii DMST 9012 (MIC 0.1-1.6 uM).