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Peptide record

TPDB04707

Antibacterial Antifungal Hemolysis Toxicity standard
50 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB04707
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb APD_complete APD_hemolytic
standard
No
A 50-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
MAGLLRFLLSKGRALYNWAKSHVGKVWEWLKSGATYEQIKEWIENALGWR
Physicochemical Analysis
C276H418N74O68S1
DCP
L
5892.87
10.30
9
4
25
+4
0.68
-0.304
91.80
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
30480
517.24
9
Residue Composition
number
5
A
3
R
2
N
0
D
0
C
4
E
1
Q
5
G
1
H
2
I
7
L
5
K
1
M
1
F
0
P
3
S
1
T
5
W
2
Y
2
V
Amino Acid Distribution
A: 5 R: 3 N: 2 D: 0 C: 0 E: 4 Q: 1 G: 5 H: 1 I: 2 L: 7 K: 5 M: 1 F: 1 P: 0 S: 3 T: 1 W: 5 Y: 2 V: 2
Chemical Descriptors
50
C276H418N74O68S1
5892.87
10.30
+4
0.68
-0.304
Evidence Records 25 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.16 µM

Target

B. subtilis ATCC 6633

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against B. subtilis ATCC 6633 (MIC 0.16 uM), L. lactis subsp. lactis LOCK 0871 strain 239 (MIC 0.89 uM), M. luteus ATCC 4698 (MIC 0.1
Evidence 2 Activity

Activity

MIC
Antibacterial
0.89 µM

Target

p. lactis LOCK 239

Source & Reference

dbAMP DRAMP

Other

Active against B. subtilis ATCC 6633 (MIC 0.16 uM), L. lactis subsp. lactis LOCK 0871 strain 239 (MIC 0.89 uM), M. luteus ATCC 4698 (MIC 0.11 uM), S. aureus DSM 26258 (CH91), S. aureus MRSA USA300 str
Evidence 3 Activity

Activity

MIC
Antibacterial
0.11 µM

Target

M. luteus ATCC 4698

Source & Reference

dbAMP DRAMP

Other

ilis ATCC 6633 (MIC 0.16 uM), L. lactis subsp. lactis LOCK 0871 strain 239 (MIC 0.89 uM), M. luteus ATCC 4698 (MIC 0.11 uM), S. aureus DSM 26258 (CH91), S. aureus MRSA USA300 strain FPR3757, S. aureus KB/8658, S.
Evidence 4 Activity

Activity

MIC
Antibacterial
0.89-1.3 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP DRAMP

Other

uM), S. aureus DSM 26258 (CH91), S. aureus MRSA USA300 strain FPR3757, S. aureus KB/8658, S. aureus ATCC 25923 (MIC 0.89-1.3 uM), S. epidermidis ATCC 35547 (MIC 4.4 uM), S. intermedius ATCC 29663, S. intermedius R-2725
Evidence 5 Activity

Activity

MIC
Antibacterial
4.4 µM

Target

Staphylococcus epidermidis ATCC 35547

Source & Reference

dbAMP DRAMP

Other

us MRSA USA300 strain FPR3757, S. aureus KB/8658, S. aureus ATCC 25923 (MIC 0.89-1.3 uM), S. epidermidis ATCC 35547 (MIC 4.4 uM), S. intermedius ATCC 29663, S. intermedius R-2725 (MIC 1.2-2 uM), S. pseudintermedius 222
Evidence 6 Activity

Activity

MIC
Antibacterial
1.2-2 µM

Target

S. intermedius R-2725

Source & Reference

dbAMP DRAMP

Other

923 (MIC 0.89-1.3 uM), S. epidermidis ATCC 35547 (MIC 4.4 uM), S. intermedius ATCC 29663, S. intermedius R-2725 (MIC 1.2-2 uM), S. pseudintermedius 222, S. pseudintermedius LMG 22219 (MIC 2.1 and 0.16 uM), S. saproph
Evidence 7 Activity

Activity

MIC
Antibacterial
0.93 µM

Target

S. saprophyticus ATCC 15305

Source & Reference

dbAMP DRAMP

Other

1.2-2 uM), S. pseudintermedius 222, S. pseudintermedius LMG 22219 (MIC 2.1 and 0.16 uM), S. saprophyticus ATCC 15305 (MIC 0.93 uM), S. pyogenes PCM 465 (MIC 7.8 uM), S. sanguinis PCM 2335 (MIC 3.5 uM), and C. albicans AT
Evidence 8 Activity

Activity

MIC
Antibacterial
7.8 µM

Target

Streptococcus pyogenes PCM 465

Source & Reference

dbAMP DRAMP

Other

udintermedius LMG 22219 (MIC 2.1 and 0.16 uM), S. saprophyticus ATCC 15305 (MIC 0.93 uM), S. pyogenes PCM 465 (MIC 7.8 uM), S. sanguinis PCM 2335 (MIC 3.5 uM), and C. albicans ATCC 10231 (MIC 100 uM). No acitivti
Evidence 9 Activity

Activity

MIC
Antibacterial
3.5 µM

Target

S. sanguinis PCM 2335

Source & Reference

dbAMP DRAMP

Other

nd 0.16 uM), S. saprophyticus ATCC 15305 (MIC 0.93 uM), S. pyogenes PCM 465 (MIC 7.8 uM), S. sanguinis PCM 2335 (MIC 3.5 uM), and C. albicans ATCC 10231 (MIC 100 uM). No acitivtiy against two Gram-negative bacteria
Evidence 10 Activity

Activity

MIC
Antibacterial
100 µM

Target

Candida albicans ATCC 10231

Source & Reference

dbAMP DRAMP

Other

(MIC 0.93 uM), S. pyogenes PCM 465 (MIC 7.8 uM), S. sanguinis PCM 2335 (MIC 3.5 uM), and C. albicans ATCC 10231 (MIC 100 uM). No acitivtiy against two Gram-negative bacteria tested E.coli K12 (MIC>100 uM), K.pneumo
Evidence 11 Activity

Activity

MIC
Antibacterial
>100 µM

Target

E.coli K12

Source & Reference

dbAMP DRAMP

Other

albicans ATCC 10231 (MIC 100 uM). No acitivtiy against two Gram-negative bacteria tested E.coli K12 (MIC>100 uM), K.pneumoniae ATCC 13886 (MIC>100 uM), S.marcescens ATCC 274 (MIC>100 uM. N-terminal form
Evidence 12 Activity

Activity

MIC
Antibacterial
>100 µM

Target

K.pneumoniae ATCC 13886

Source & Reference

dbAMP DRAMP

Other

100 uM). No acitivtiy against two Gram-negative bacteria tested E.coli K12 (MIC>100 uM), K.pneumoniae ATCC 13886 (MIC>100 uM), S.marcescens ATCC 274 (MIC>100 uM. N-terminal formylation is not needed for antibacteria
Evidence 13 Activity

Activity

MIC
Antifungal
0.16 µM

Target

B. subtilis ATCC 6633

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against B. subtilis ATCC 6633 (MIC 0.16 uM), L. lactis subsp. lactis LOCK 0871 strain 239 (MIC 0.89 uM), M. luteus ATCC 4698 (MIC 0.1
Evidence 14 Activity

Activity

MIC
Antifungal
0.89 µM

Target

p. lactis LOCK 239

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against B. subtilis ATCC 6633 (MIC 0.16 uM), L. lactis subsp. lactis LOCK 0871 strain 239 (MIC 0.89 uM), M. luteus ATCC 4698 (MIC 0.11 uM), S. aureus DSM 26258 (CH91), S. aureus MRSA USA300 str
Evidence 15 Activity

Activity

MIC
Antifungal
0.11 µM

Target

M. luteus ATCC 4698

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ilis ATCC 6633 (MIC 0.16 uM), L. lactis subsp. lactis LOCK 0871 strain 239 (MIC 0.89 uM), M. luteus ATCC 4698 (MIC 0.11 uM), S. aureus DSM 26258 (CH91), S. aureus MRSA USA300 strain FPR3757, S. aureus KB/8658, S.
Evidence 16 Activity

Activity

MIC
Antifungal
0.89-1.3 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

uM), S. aureus DSM 26258 (CH91), S. aureus MRSA USA300 strain FPR3757, S. aureus KB/8658, S. aureus ATCC 25923 (MIC 0.89-1.3 uM), S. epidermidis ATCC 35547 (MIC 4.4 uM), S. intermedius ATCC 29663, S. intermedius R-2725
Evidence 17 Activity

Activity

MIC
Antifungal
4.4 µM

Target

Staphylococcus epidermidis ATCC 35547

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

us MRSA USA300 strain FPR3757, S. aureus KB/8658, S. aureus ATCC 25923 (MIC 0.89-1.3 uM), S. epidermidis ATCC 35547 (MIC 4.4 uM), S. intermedius ATCC 29663, S. intermedius R-2725 (MIC 1.2-2 uM), S. pseudintermedius 222
Evidence 18 Activity

Activity

MIC
Antifungal
1.2-2 µM

Target

S. intermedius R-2725

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

923 (MIC 0.89-1.3 uM), S. epidermidis ATCC 35547 (MIC 4.4 uM), S. intermedius ATCC 29663, S. intermedius R-2725 (MIC 1.2-2 uM), S. pseudintermedius 222, S. pseudintermedius LMG 22219 (MIC 2.1 and 0.16 uM), S. saproph
Evidence 19 Activity

Activity

MIC
Antifungal
0.93 µM

Target

S. saprophyticus ATCC 15305

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

1.2-2 uM), S. pseudintermedius 222, S. pseudintermedius LMG 22219 (MIC 2.1 and 0.16 uM), S. saprophyticus ATCC 15305 (MIC 0.93 uM), S. pyogenes PCM 465 (MIC 7.8 uM), S. sanguinis PCM 2335 (MIC 3.5 uM), and C. albicans AT
Evidence 20 Activity

Activity

MIC
Antifungal
7.8 µM

Target

Streptococcus pyogenes PCM 465

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

udintermedius LMG 22219 (MIC 2.1 and 0.16 uM), S. saprophyticus ATCC 15305 (MIC 0.93 uM), S. pyogenes PCM 465 (MIC 7.8 uM), S. sanguinis PCM 2335 (MIC 3.5 uM), and C. albicans ATCC 10231 (MIC 100 uM). No acitivti
Evidence 21 Activity

Activity

MIC
Antifungal
3.5 µM

Target

S. sanguinis PCM 2335

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

nd 0.16 uM), S. saprophyticus ATCC 15305 (MIC 0.93 uM), S. pyogenes PCM 465 (MIC 7.8 uM), S. sanguinis PCM 2335 (MIC 3.5 uM), and C. albicans ATCC 10231 (MIC 100 uM). No acitivtiy against two Gram-negative bacteria
Evidence 22 Activity

Activity

MIC
Antifungal
100 µM

Target

Candida albicans ATCC 10231

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

(MIC 0.93 uM), S. pyogenes PCM 465 (MIC 7.8 uM), S. sanguinis PCM 2335 (MIC 3.5 uM), and C. albicans ATCC 10231 (MIC 100 uM). No acitivtiy against two Gram-negative bacteria tested E.coli K12 (MIC>100 uM), K.pneumo
Evidence 23 Activity

Activity

MIC
Antifungal
>100 µM

Target

E.coli K12

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

albicans ATCC 10231 (MIC 100 uM). No acitivtiy against two Gram-negative bacteria tested E.coli K12 (MIC>100 uM), K.pneumoniae ATCC 13886 (MIC>100 uM), S.marcescens ATCC 274 (MIC>100 uM. N-terminal form
Evidence 24 Activity

Activity

MIC
Antifungal
>100 µM

Target

K.pneumoniae ATCC 13886

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

100 uM). No acitivtiy against two Gram-negative bacteria tested E.coli K12 (MIC>100 uM), K.pneumoniae ATCC 13886 (MIC>100 uM), S.marcescens ATCC 274 (MIC>100 uM. N-terminal formylation is not needed for antibacteria
Evidence 25 Hemolysis

Source & Reference

APD_complete APD_hemolytic
APD_complete APD_hemolytic

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.