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Peptide record

TPDB04702

Antibacterial Anticancer Antifungal Antiparasitic Antiviral standard
49 amino acids
Basic Information
3D PDB MODEL
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TPDB04702
Antibacterial Anticancer Antifungal Antiparasitic Antiviral
Anti-infective peptides Cancer-related peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb
standard
No
A 49-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
NLCERASLTWTGNCGNTGHCDTQCRNWESAKHGACHKRGNWKCFCYFDC
Physicochemical Analysis
C234H344N76O71S8
IMPV
C
5614.25
7.86
9
4
11
+2
6.03
-0.849
22.04
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
18490
329.34
21
Residue Composition
number
3
A
3
R
5
N
2
D
8
C
2
E
1
Q
5
G
3
H
0
I
2
L
3
K
0
M
2
F
0
P
2
S
4
T
3
W
1
Y
0
V
Amino Acid Distribution
A: 3 R: 3 N: 5 D: 2 C: 8 E: 2 Q: 1 G: 5 H: 3 I: 0 L: 2 K: 3 M: 0 F: 2 P: 0 S: 2 T: 4 W: 3 Y: 1 V: 0
Chemical Descriptors
49
C234H344N76O71S8
5614.25
7.86
+2
6.03
-0.849
Evidence Records 28 records
Evidence 1 Activity

Activity

IC50
Antibacterial
20 µg/mL

Target

B. cinerea

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
medium A supplemented with 1 mM CaCl2 and 50 mM KCl, the peptide is active against fungi B. cinerea (IC50 20 ug/ml), C. sphaerospermum (IC50 6 ug/ml), F. culmorum (IC50 10 ug/ml), L. maculans (IC50 6 ug/ml
Evidence 2 Activity

Activity

IC50
Antibacterial
6 µg/mL

Target

C. sphaerospermum

Source & Reference

dbAMP DRAMP

Other

1 mM CaCl2 and 50 mM KCl, the peptide is active against fungi B. cinerea (IC50 20 ug/ml), C. sphaerospermum (IC50 6 ug/ml), F. culmorum (IC50 10 ug/ml), L. maculans (IC50 6 ug/ml), P. digitatum (IC50 20 ug/ml), S
Evidence 3 Activity

Activity

IC50
Antibacterial
10 µg/mL

Target

F. culmorum

Source & Reference

dbAMP DRAMP

Other

ide is active against fungi B. cinerea (IC50 20 ug/ml), C. sphaerospermum (IC50 6 ug/ml), F. culmorum (IC50 10 ug/ml), L. maculans (IC50 6 ug/ml), P. digitatum (IC50 20 ug/ml), S. tritici (IC50 2 ug/ml), and
Evidence 4 Activity

Activity

IC50
Antibacterial
6 µg/mL

Target

L. maculans

Source & Reference

dbAMP DRAMP

Other

. cinerea (IC50 20 ug/ml), C. sphaerospermum (IC50 6 ug/ml), F. culmorum (IC50 10 ug/ml), L. maculans (IC50 6 ug/ml), P. digitatum (IC50 20 ug/ml), S. tritici (IC50 2 ug/ml), and V. albo-atrum (IC50 2 ug/ml
Evidence 5 Activity

Activity

IC50
Antibacterial
20 µg/mL

Target

P. digitatum

Source & Reference

dbAMP DRAMP

Other

. sphaerospermum (IC50 6 ug/ml), F. culmorum (IC50 10 ug/ml), L. maculans (IC50 6 ug/ml), P. digitatum (IC50 20 ug/ml), S. tritici (IC50 2 ug/ml), and V. albo-atrum (IC50 2 ug/ml) (FEBS Lett. 1995 Jul 17 368(
Evidence 6 Activity

Activity

IC50
Antibacterial
2 µg/mL

Target

S. tritici

Source & Reference

dbAMP DRAMP

Other

), F. culmorum (IC50 10 ug/ml), L. maculans (IC50 6 ug/ml), P. digitatum (IC50 20 ug/ml), S. tritici (IC50 2 ug/ml), and V. albo-atrum (IC50 2 ug/ml) (FEBS Lett. 1995 Jul 17 368(2):257-62). Replaced 7/2008
Evidence 7 Activity

Activity

IC50
Antibacterial
2 µg/mL

Target

V. albo-atrum

Source & Reference

dbAMP DRAMP

Other

L. maculans (IC50 6 ug/ml), P. digitatum (IC50 20 ug/ml), S. tritici (IC50 2 ug/ml), and V. albo-atrum (IC50 2 ug/ml) (FEBS Lett. 1995 Jul 17 368(2):257-62). Replaced 7/2008 updated Jan2017 7/2021 GW.
Evidence 8 Activity

Activity

IC50
Antifungal
20 µg/mL

Target

B. cinerea

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
medium A supplemented with 1 mM CaCl2 and 50 mM KCl, the peptide is active against fungi B. cinerea (IC50 20 ug/ml), C. sphaerospermum (IC50 6 ug/ml), F. culmorum (IC50 10 ug/ml), L. maculans (IC50 6 ug/ml
Evidence 9 Activity

Activity

IC50
Antifungal
6 µg/mL

Target

C. sphaerospermum

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

1 mM CaCl2 and 50 mM KCl, the peptide is active against fungi B. cinerea (IC50 20 ug/ml), C. sphaerospermum (IC50 6 ug/ml), F. culmorum (IC50 10 ug/ml), L. maculans (IC50 6 ug/ml), P. digitatum (IC50 20 ug/ml), S
Evidence 10 Activity

Activity

IC50
Antifungal
10 µg/mL

Target

F. culmorum

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ide is active against fungi B. cinerea (IC50 20 ug/ml), C. sphaerospermum (IC50 6 ug/ml), F. culmorum (IC50 10 ug/ml), L. maculans (IC50 6 ug/ml), P. digitatum (IC50 20 ug/ml), S. tritici (IC50 2 ug/ml), and
Evidence 11 Activity

Activity

IC50
Antifungal
6 µg/mL

Target

L. maculans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

. cinerea (IC50 20 ug/ml), C. sphaerospermum (IC50 6 ug/ml), F. culmorum (IC50 10 ug/ml), L. maculans (IC50 6 ug/ml), P. digitatum (IC50 20 ug/ml), S. tritici (IC50 2 ug/ml), and V. albo-atrum (IC50 2 ug/ml
Evidence 12 Activity

Activity

IC50
Antifungal
20 µg/mL

Target

P. digitatum

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

. sphaerospermum (IC50 6 ug/ml), F. culmorum (IC50 10 ug/ml), L. maculans (IC50 6 ug/ml), P. digitatum (IC50 20 ug/ml), S. tritici (IC50 2 ug/ml), and V. albo-atrum (IC50 2 ug/ml) (FEBS Lett. 1995 Jul 17 368(
Evidence 13 Activity

Activity

IC50
Antifungal
2 µg/mL

Target

S. tritici

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

), F. culmorum (IC50 10 ug/ml), L. maculans (IC50 6 ug/ml), P. digitatum (IC50 20 ug/ml), S. tritici (IC50 2 ug/ml), and V. albo-atrum (IC50 2 ug/ml) (FEBS Lett. 1995 Jul 17 368(2):257-62). Replaced 7/2008
Evidence 14 Activity

Activity

IC50
Antifungal
2 µg/mL

Target

V. albo-atrum

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

L. maculans (IC50 6 ug/ml), P. digitatum (IC50 20 ug/ml), S. tritici (IC50 2 ug/ml), and V. albo-atrum (IC50 2 ug/ml) (FEBS Lett. 1995 Jul 17 368(2):257-62). Replaced 7/2008 updated Jan2017 7/2021 GW.
Evidence 15 Activity

Activity

IC50
Antiparasitic
20 µg/mL

Target

B. cinerea

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
medium A supplemented with 1 mM CaCl2 and 50 mM KCl, the peptide is active against fungi B. cinerea (IC50 20 ug/ml), C. sphaerospermum (IC50 6 ug/ml), F. culmorum (IC50 10 ug/ml), L. maculans (IC50 6 ug/ml
Evidence 16 Activity

Activity

IC50
Antiparasitic
6 µg/mL

Target

C. sphaerospermum

Source & Reference

DRAMP

Other

1 mM CaCl2 and 50 mM KCl, the peptide is active against fungi B. cinerea (IC50 20 ug/ml), C. sphaerospermum (IC50 6 ug/ml), F. culmorum (IC50 10 ug/ml), L. maculans (IC50 6 ug/ml), P. digitatum (IC50 20 ug/ml), S
Evidence 17 Activity

Activity

IC50
Antiparasitic
10 µg/mL

Target

F. culmorum

Source & Reference

DRAMP

Other

ide is active against fungi B. cinerea (IC50 20 ug/ml), C. sphaerospermum (IC50 6 ug/ml), F. culmorum (IC50 10 ug/ml), L. maculans (IC50 6 ug/ml), P. digitatum (IC50 20 ug/ml), S. tritici (IC50 2 ug/ml), and
Evidence 18 Activity

Activity

IC50
Antiparasitic
6 µg/mL

Target

L. maculans

Source & Reference

DRAMP

Other

. cinerea (IC50 20 ug/ml), C. sphaerospermum (IC50 6 ug/ml), F. culmorum (IC50 10 ug/ml), L. maculans (IC50 6 ug/ml), P. digitatum (IC50 20 ug/ml), S. tritici (IC50 2 ug/ml), and V. albo-atrum (IC50 2 ug/ml
Evidence 19 Activity

Activity

IC50
Antiparasitic
20 µg/mL

Target

P. digitatum

Source & Reference

DRAMP

Other

. sphaerospermum (IC50 6 ug/ml), F. culmorum (IC50 10 ug/ml), L. maculans (IC50 6 ug/ml), P. digitatum (IC50 20 ug/ml), S. tritici (IC50 2 ug/ml), and V. albo-atrum (IC50 2 ug/ml) (FEBS Lett. 1995 Jul 17 368(
Evidence 20 Activity

Activity

IC50
Antiparasitic
2 µg/mL

Target

S. tritici

Source & Reference

DRAMP

Other

), F. culmorum (IC50 10 ug/ml), L. maculans (IC50 6 ug/ml), P. digitatum (IC50 20 ug/ml), S. tritici (IC50 2 ug/ml), and V. albo-atrum (IC50 2 ug/ml) (FEBS Lett. 1995 Jul 17 368(2):257-62). Replaced 7/2008
Evidence 21 Activity

Activity

IC50
Antiparasitic
2 µg/mL

Target

V. albo-atrum

Source & Reference

DRAMP

Other

L. maculans (IC50 6 ug/ml), P. digitatum (IC50 20 ug/ml), S. tritici (IC50 2 ug/ml), and V. albo-atrum (IC50 2 ug/ml) (FEBS Lett. 1995 Jul 17 368(2):257-62). Replaced 7/2008 updated Jan2017 7/2021 GW.
Evidence 22 Activity

Activity

IC50
Antiviral
20 µg/mL

Target

B. cinerea

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
medium A supplemented with 1 mM CaCl2 and 50 mM KCl, the peptide is active against fungi B. cinerea (IC50 20 ug/ml), C. sphaerospermum (IC50 6 ug/ml), F. culmorum (IC50 10 ug/ml), L. maculans (IC50 6 ug/ml
Evidence 23 Activity

Activity

IC50
Antiviral
6 µg/mL

Target

C. sphaerospermum

Source & Reference

DRAMP

Other

1 mM CaCl2 and 50 mM KCl, the peptide is active against fungi B. cinerea (IC50 20 ug/ml), C. sphaerospermum (IC50 6 ug/ml), F. culmorum (IC50 10 ug/ml), L. maculans (IC50 6 ug/ml), P. digitatum (IC50 20 ug/ml), S
Evidence 24 Activity

Activity

IC50
Antiviral
10 µg/mL

Target

F. culmorum

Source & Reference

DRAMP

Other

ide is active against fungi B. cinerea (IC50 20 ug/ml), C. sphaerospermum (IC50 6 ug/ml), F. culmorum (IC50 10 ug/ml), L. maculans (IC50 6 ug/ml), P. digitatum (IC50 20 ug/ml), S. tritici (IC50 2 ug/ml), and
Evidence 25 Activity

Activity

IC50
Antiviral
6 µg/mL

Target

L. maculans

Source & Reference

DRAMP

Other

. cinerea (IC50 20 ug/ml), C. sphaerospermum (IC50 6 ug/ml), F. culmorum (IC50 10 ug/ml), L. maculans (IC50 6 ug/ml), P. digitatum (IC50 20 ug/ml), S. tritici (IC50 2 ug/ml), and V. albo-atrum (IC50 2 ug/ml
Evidence 26 Activity

Activity

IC50
Antiviral
20 µg/mL

Target

P. digitatum

Source & Reference

DRAMP

Other

. sphaerospermum (IC50 6 ug/ml), F. culmorum (IC50 10 ug/ml), L. maculans (IC50 6 ug/ml), P. digitatum (IC50 20 ug/ml), S. tritici (IC50 2 ug/ml), and V. albo-atrum (IC50 2 ug/ml) (FEBS Lett. 1995 Jul 17 368(
Evidence 27 Activity

Activity

IC50
Antiviral
2 µg/mL

Target

S. tritici

Source & Reference

DRAMP

Other

), F. culmorum (IC50 10 ug/ml), L. maculans (IC50 6 ug/ml), P. digitatum (IC50 20 ug/ml), S. tritici (IC50 2 ug/ml), and V. albo-atrum (IC50 2 ug/ml) (FEBS Lett. 1995 Jul 17 368(2):257-62). Replaced 7/2008
Evidence 28 Activity

Activity

IC50
Antiviral
2 µg/mL

Target

V. albo-atrum

Source & Reference

DRAMP

Other

L. maculans (IC50 6 ug/ml), P. digitatum (IC50 20 ug/ml), S. tritici (IC50 2 ug/ml), and V. albo-atrum (IC50 2 ug/ml) (FEBS Lett. 1995 Jul 17 368(2):257-62). Replaced 7/2008 updated Jan2017 7/2021 GW.