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Peptide record

TPDB04653

Antibacterial Antifungal standard
43 amino acids
Basic Information
3D PDB MODEL
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TPDB04653
Antibacterial Antifungal
Anti-infective peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept
standard
No
A 43-aa standard natural multi-activity (Antibacterial and Antifungal) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
ATYYGNGVYCNKQECWVDWNKASKEIGKIIVNGWVQHGPWAPR
Physicochemical Analysis
C227H330N62O61S2
LMF
G
4967.62
8.90
6
3
17
+2
3.20
-0.658
61.16
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
26595
535.37
13
Residue Composition
number
3
A
1
R
4
N
1
D
2
C
2
E
2
Q
5
G
1
H
3
I
0
L
4
K
0
M
0
F
2
P
1
S
1
T
4
W
3
Y
4
V
Amino Acid Distribution
A: 3 R: 1 N: 4 D: 1 C: 2 E: 2 Q: 2 G: 5 H: 1 I: 3 L: 0 K: 4 M: 0 F: 0 P: 2 S: 1 T: 1 W: 4 Y: 3 V: 4
Chemical Descriptors
43
C227H330N62O61S2
4967.62
8.90
+2
3.20
-0.658
Evidence Records 2 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Plasmid-encoded bacteriocin is active against the indicator strain E. durans 41D-S1, L. monocytogenes strains, including nisin-resistant L. monocytogenes NR30. Both durancin GL and bacteriocin 31 pre-peptides include leader sequences that are recognized by a sec-dependent translocation system and do not require bacteriocin-specific translocation proteins. Thus, other LAB strains possessing a sec-dependent transmembrane transport system may also be suitable hosts for the production of durancin GL. Alanine scanclearly influeces peptide activity ( Ju X et al., 2015 ).
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Plasmid-encoded bacteriocin is active against the indicator strain E. durans 41D-S1, L. monocytogenes strains, including nisin-resistant L. monocytogenes NR30. Both durancin GL and bacteriocin 31 pre-peptides include leader sequences that are recognized by a sec-dependent translocation system and do not require bacteriocin-specific translocation proteins. Thus, other LAB strains possessing a sec-dependent transmembrane transport system may also be suitable hosts for the production of durancin GL. Alanine scanclearly influeces peptide activity ( Ju X et al., 2015 ).