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Peptide record

TPDB04652

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
43 amino acids
Basic Information
3D PDB MODEL
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TPDB04652
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept APD_complete HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 43-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
LTCDLLSFEAKGFAANHSLCAAHCLAIGRKGGACQNGVCVCRR
Physicochemical Analysis
C187H307N61O54S6
MPWY
A
4466.23
8.32
7
2
17
+3
3.59
0.363
84.19
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
375
8.40
12
Residue Composition
number
7
A
3
R
2
N
1
D
6
C
1
E
1
Q
5
G
2
H
1
I
5
L
2
K
0
M
2
F
0
P
2
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 7 R: 3 N: 2 D: 1 C: 6 E: 1 Q: 1 G: 5 H: 2 I: 1 L: 5 K: 2 M: 0 F: 2 P: 0 S: 2 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
43
C187H307N61O54S6
4466.23
8.32
+3
3.59
0.363
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>100 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >100 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Antibacterial activity and mechanism of action of tick defensin against Gram-positive bacteria. | Biochim Biophys Acta | 2003
Evidence 2 Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.