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Peptide record

TPDB04639

Antibacterial Antifungal Toxicity standard
43 amino acids
Basic Information
3D PDB MODEL
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TPDB04639
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse CAFPdb
standard
No
A 43-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
ATCDLLSASTPWGSLNHSACAAHCLTKRYKGGRCRNGICRCRR
Physicochemical Analysis
C192H318N70O56S6
EQMFV
RC
4695.43
9.77
10
1
12
+7
4.63
-0.435
56.98
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
7365
156.85
16
Residue Composition
number
5
A
6
R
2
N
1
D
6
C
0
E
0
Q
4
G
2
H
1
I
4
L
2
K
0
M
0
F
1
P
4
S
3
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 5 R: 6 N: 2 D: 1 C: 6 E: 0 Q: 0 G: 4 H: 2 I: 1 L: 4 K: 2 M: 0 F: 0 P: 1 S: 4 T: 3 W: 1 Y: 1 V: 0
Chemical Descriptors
43
C192H318N70O56S6
4695.43
9.77
+7
4.63
-0.435
Evidence Records 14 records
Evidence 1 Activity

Activity

MIC
Antibacterial
>100 µg/mL

Target

E.coli DH5alpha

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against E.coli DH5alpha (MIC >100 ug/ml), S. aureus ATCC 29213 (MIC 6.8 ug/ml), B. subtilis (MIC 5.8 uM), C. albicans ATCC 90028 (
Evidence 2 Activity

Activity

MIC
Antibacterial
6.8 µg/mL

Target

Staphylococcus aureus ATCC 29213

Source & Reference

dbAMP DRAMP

Other

active against E.coli DH5alpha (MIC >100 ug/ml), S. aureus ATCC 29213 (MIC 6.8 ug/ml), B. subtilis (MIC 5.8 uM), C. albicans ATCC 90028 (MIC 7.8 ug/ml), P. aeruginosa ATCC 278
Evidence 3 Activity

Activity

MIC
Antibacterial
5.8 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

active against E.coli DH5alpha (MIC >100 ug/ml), S. aureus ATCC 29213 (MIC 6.8 ug/ml), B. subtilis (MIC 5.8 uM), C. albicans ATCC 90028 (MIC 7.8 ug/ml), P. aeruginosa ATCC 27850 (MIC 43.7 ug/ml), and K
Evidence 4 Activity

Activity

MIC
Antibacterial
7.8 µg/mL

Target

Candida albicans ATCC 90028

Source & Reference

dbAMP DRAMP

Other

H5alpha (MIC >100 ug/ml), S. aureus ATCC 29213 (MIC 6.8 ug/ml), B. subtilis (MIC 5.8 uM), C. albicans ATCC 90028 (MIC 7.8 ug/ml), P. aeruginosa ATCC 27850 (MIC 43.7 ug/ml), and K. pneumoniae ATCC 700603 (MIC 26.6 ug/ml
Evidence 5 Activity

Activity

MIC
Antibacterial
43.7 µg/mL

Target

Pseudomonas aeruginosa ATCC 27850

Source & Reference

dbAMP DRAMP

Other

29213 (MIC 6.8 ug/ml), B. subtilis (MIC 5.8 uM), C. albicans ATCC 90028 (MIC 7.8 ug/ml), P. aeruginosa ATCC 27850 (MIC 43.7 ug/ml), and K. pneumoniae ATCC 700603 (MIC 26.6 ug/ml).
Evidence 6 Activity

Activity

MIC
Antibacterial
26.6 µg/mL

Target

Klebsiella pneumoniae ATCC 700603

Source & Reference

dbAMP DRAMP

Other

), C. albicans ATCC 90028 (MIC 7.8 ug/ml), P. aeruginosa ATCC 27850 (MIC 43.7 ug/ml), and K. pneumoniae ATCC 700603 (MIC 26.6 ug/ml).
Evidence 7 Activity

Activity

MIC
Antifungal
>100 µg/mL

Target

E.coli DH5alpha

Source & Reference

dbAMP DRAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
active against E.coli DH5alpha (MIC >100 ug/ml), S. aureus ATCC 29213 (MIC 6.8 ug/ml), B. subtilis (MIC 5.8 uM), C. albicans ATCC 90028 (
Evidence 8 Activity

Activity

MIC
Antifungal
6.8 µg/mL

Target

Staphylococcus aureus ATCC 29213

Source & Reference

dbAMP DRAMP CAFPdb

Other

active against E.coli DH5alpha (MIC >100 ug/ml), S. aureus ATCC 29213 (MIC 6.8 ug/ml), B. subtilis (MIC 5.8 uM), C. albicans ATCC 90028 (MIC 7.8 ug/ml), P. aeruginosa ATCC 278
Evidence 9 Activity

Activity

MIC
Antifungal
5.8 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb

Other

active against E.coli DH5alpha (MIC >100 ug/ml), S. aureus ATCC 29213 (MIC 6.8 ug/ml), B. subtilis (MIC 5.8 uM), C. albicans ATCC 90028 (MIC 7.8 ug/ml), P. aeruginosa ATCC 27850 (MIC 43.7 ug/ml), and K
Evidence 10 Activity

Activity

MIC
Antifungal
7.8 µg/mL

Target

Candida albicans ATCC 90028

Source & Reference

dbAMP DRAMP CAFPdb

Other

H5alpha (MIC >100 ug/ml), S. aureus ATCC 29213 (MIC 6.8 ug/ml), B. subtilis (MIC 5.8 uM), C. albicans ATCC 90028 (MIC 7.8 ug/ml), P. aeruginosa ATCC 27850 (MIC 43.7 ug/ml), and K. pneumoniae ATCC 700603 (MIC 26.6 ug/ml
Evidence 11 Activity

Activity

MIC
Antifungal
43.7 µg/mL

Target

Pseudomonas aeruginosa ATCC 27850

Source & Reference

dbAMP DRAMP CAFPdb

Other

29213 (MIC 6.8 ug/ml), B. subtilis (MIC 5.8 uM), C. albicans ATCC 90028 (MIC 7.8 ug/ml), P. aeruginosa ATCC 27850 (MIC 43.7 ug/ml), and K. pneumoniae ATCC 700603 (MIC 26.6 ug/ml).
Evidence 12 Activity

Activity

MIC
Antifungal
26.6 µg/mL

Target

Klebsiella pneumoniae ATCC 700603

Source & Reference

dbAMP DRAMP CAFPdb

Other

), C. albicans ATCC 90028 (MIC 7.8 ug/ml), P. aeruginosa ATCC 27850 (MIC 43.7 ug/ml), and K. pneumoniae ATCC 700603 (MIC 26.6 ug/ml).
Evidence 13 Activity

Activity

0% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 200 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Identification and screening of potent antimicrobial peptides in arthropod genomes. | Peptides | 2018
Evidence 14 Activity

Activity

% Hemolysis
Toxicity
0 %
Hemolytic
Hemolytic_activity: [Ref.29501691] 0% haemolysis at 10 µg/ml, 0% haemolysis at 25 µg/ml, 0% haemolysis at 50 µg/ml, 0% haemolysis at 100 µg/ml, 0% haemolysis at 200 µg/ml against sheep red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2018 May 103:26-30.