TPDB

3D PDB MODEL

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TPDB ID TPDB04636

Activity

Antibacterial Antifungal

Activity_category_statistics

Anti-infective peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb

Sequence_Type

standard

Has_Modification No

Description A 42-aa standard natural multi-activity (Antibacterial and Antifungal) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

ANKCIIDCMKVKTTCGDECKGAGFKTGGCALPPDIMKCCHNC

FASTA

>TPDB04636|Antibacterial;Antifungal|length=42
ANKCIIDCMKVKTTCGDECKGAGFKTGGCALPPDIMKCCHNC

Formula C180H300N52O56S10

Absent Amino Acids RQSWY

Common Amino Acids C

Mass 4409.28

PI 7.85

Basic Residues 7

Acidic Residues 4

Hydrophobic Residues 11

Net Charge +2

Boman Index 9.38

Hydrophobicity -0.033

Aliphatic Index 51.19

Half Life

Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 500

Absorbance 280nm 11.34

Polar Residues 13

number

3

A

0

R

2

N

3

D

8

C

1

E

0

Q

5

G

1

H

3

I

1

L

6

K

2

M

1

F

2

P

0

S

3

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 3 R: 0 N: 2 D: 3 C: 8 E: 1 Q: 0 G: 5 H: 1 I: 3 L: 1 K: 6 M: 2 F: 1 P: 2 S: 0 T: 3 W: 0 Y: 0 V: 1

Length

42

Formula

C180H300N52O56S10

Mass

4409.28

PI

7.85

Net Charge

+2

Boman Index

9.38

Hydrophobicity

-0.033

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 5.7 µM

Target

Target Organism F. oxysporum

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

ease causing X. campestris, and Gram+ B. subtilis (0.8-1.2 cm). Also active against fungi F. oxysporum (IC50 5.7 uM), A. niger (IC50 1.2 uM), but no activity below 10 uM against B-cinerea, B-sorokiniana, P-

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 1.2 µM

Target

Target Organism A. niger

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

and Gram+ B. subtilis (0.8-1.2 cm). Also active against fungi F. oxysporum (IC50 5.7 uM), A. niger (IC50 1.2 uM), but no activity below 10 uM against B-cinerea, B-sorokiniana, P-debaryanum, and F-gramin

Evidence 3 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 5.7 µM

Target

Target Organism F. oxysporum

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

ease causing X. campestris, and Gram+ B. subtilis (0.8-1.2 cm). Also active against fungi F. oxysporum (IC50 5.7 uM), A. niger (IC50 1.2 uM), but no activity below 10 uM against B-cinerea, B-sorokiniana, P-

Evidence 4 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 1.2 µM

Target

Target Organism A. niger

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

and Gram+ B. subtilis (0.8-1.2 cm). Also active against fungi F. oxysporum (IC50 5.7 uM), A. niger (IC50 1.2 uM), but no activity below 10 uM against B-cinerea, B-sorokiniana, P-debaryanum, and F-gramin