TPDB

3D PDB MODEL

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TPDB ID TPDB04628

Activity

Antibacterial Anticancer Antifungal Antiparasitic

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF Antifungipept

Sequence_Type

standard

Has_Modification No

Description A 41-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

ARSYGNGVYCNNKKCWVNRGEATQSIIGGMISGWASGLAGM

FASTA

>TPDB04628|Antibacterial;Anticancer;Antifungal;Antiparasitic|length=41
ARSYGNGVYCNNKKCWVNRGEATQSIIGGMISGWASGLAGM

Formula C184H288N56O56S4

Absent Amino Acids DHFP

Common Amino Acids G

Mass 4308.89

PI 9.56

Basic Residues 4

Acidic Residues 1

Hydrophobic Residues 16

Net Charge +3

Boman Index 0.07

Hydrophobicity -0.185

Aliphatic Index 61.95

Half Life

Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 14105

Absorbance 280nm 327.35

Polar Residues 14

number

4

A

2

R

4

N

0

D

2

C

1

E

1

Q

8

G

0

H

3

I

1

L

2

K

2

M

0

F

0

P

4

S

1

T

2

W

2

Y

2

V

Amino Acid Distribution

A: 4 R: 2 N: 4 D: 0 C: 2 E: 1 Q: 1 G: 8 H: 0 I: 3 L: 1 K: 2 M: 2 F: 0 P: 0 S: 4 T: 1 W: 2 Y: 2 V: 2

Length

41

Formula

C184H288N56O56S4

Mass

4308.89

PI

9.56

Net Charge

+3

Boman Index

0.07

Hydrophobicity

-0.185

Evidence 1 Activity

Activity

Detail Source Activity Antibacterial

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

Showed killing of L. brevis indicator strain but bacteriostatic effect on L. sake Lb706-B, L. sake L45D, and L. cremoris LM023.

Evidence 2 Activity

Activity

Detail Source Activity Antifungal

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

Showed killing of L. brevis indicator strain but bacteriostatic effect on L. sake Lb706-B, L. sake L45D, and L. cremoris LM023.

Evidence 3 Activity

Activity

Detail Source Activity Antiparasitic

Source & Reference

Database Source DRAMP

Other

Evidence Text

Showed killing of L. brevis indicator strain but bacteriostatic effect on L. sake Lb706-B, L. sake L45D, and L. cremoris LM023.