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Peptide record

TPDB04627

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard

41 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB04627

Activity

Antibacterial Anticancer Antifungal Antiparasitic Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb

Sequence_Type

standard

Has_Modification No

Description A 41-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

QQCGRQASGRLCGNRLCCSQWGYCGSTASYCGAGCQSQCRS

FASTA

>TPDB04627|Antibacterial;Anticancer;Antifungal;Antiparasitic;Toxicity|length=41
QQCGRQASGRLCGNRLCCSQWGYCGSTASYCGAGCQSQCRS

Formula C168H267N61O58S8

Absent Amino Acids DEHIKMFPV

Common Amino Acids C

Mass 4325.82

PI 8.31

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 8

Net Charge +4

Boman Index 0.85

Hydrophobicity -0.520

Aliphatic Index 26.34

Half Life

Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour

Extinction Coefficient Cystines 8980

Absorbance 280nm 207.59

Polar Residues 24

number

Amino Acid Distribution

A: 3 R: 4 N: 1 D: 0 C: 8 E: 0 Q: 6 G: 7 H: 0 I: 0 L: 2 K: 0 M: 0 F: 0 P: 0 S: 6 T: 1 W: 1 Y: 2 V: 0

Length

Formula

C168H267N61O58S8

Mass

4325.82

8.31

Net Charge

Boman Index

0.85

Hydrophobicity

-0.520

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 16 µg/mL

Target

Target Organism B. cinerea

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against B. cinerea (IC50 16 ug/ml), C. langenarium (IC50 4 ug/ml), S. sclerotiorum (IC50 11 ug/ml), F. oxysporum (IC50 10 ug

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 4 µg/mL

Target

Target Organism C. langenarium

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against B. cinerea (IC50 16 ug/ml), C. langenarium (IC50 4 ug/ml), S. sclerotiorum (IC50 11 ug/ml), F. oxysporum (IC50 10 ug/ml), S. cerevissiae (IC50 14 u

Evidence 3 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 11 µg/mL

Target

Target Organism S. sclerotiorum

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against B. cinerea (IC50 16 ug/ml), C. langenarium (IC50 4 ug/ml), S. sclerotiorum (IC50 11 ug/ml), F. oxysporum (IC50 10 ug/ml), S. cerevissiae (IC50 14 ug/ml), R. solani (IC50 26 ug/ml),

Evidence 4 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 10 µg/mL

Target

Target Organism F. oxysporum

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

cinerea (IC50 16 ug/ml), C. langenarium (IC50 4 ug/ml), S. sclerotiorum (IC50 11 ug/ml), F. oxysporum (IC50 10 ug/ml), S. cerevissiae (IC50 14 ug/ml), R. solani (IC50 26 ug/ml), P. capsici (IC50 5 ug/ml), Py

Evidence 5 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 14 µg/mL

Target

Target Organism S. cerevissiae

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

angenarium (IC50 4 ug/ml), S. sclerotiorum (IC50 11 ug/ml), F. oxysporum (IC50 10 ug/ml), S. cerevissiae (IC50 14 ug/ml), R. solani (IC50 26 ug/ml), P. capsici (IC50 5 ug/ml), Pythium spp. (ND), and P. parasiti

Evidence 6 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 26 µg/mL

Target

Target Organism R. solani

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

lerotiorum (IC50 11 ug/ml), F. oxysporum (IC50 10 ug/ml), S. cerevissiae (IC50 14 ug/ml), R. solani (IC50 26 ug/ml), P. capsici (IC50 5 ug/ml), Pythium spp. (ND), and P. parasitica (IC50 3 ug/ml). It also

Evidence 7 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 5 µg/mL

Target

Target Organism P. capsici

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

F. oxysporum (IC50 10 ug/ml), S. cerevissiae (IC50 14 ug/ml), R. solani (IC50 26 ug/ml), P. capsici (IC50 5 ug/ml), Pythium spp. (ND), and P. parasitica (IC50 3 ug/ml). It also inhibited B. subtilis (IC50

Evidence 8 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 3 µg/mL

Target

Target Organism P. parasitica

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

0 14 ug/ml), R. solani (IC50 26 ug/ml), P. capsici (IC50 5 ug/ml), Pythium spp. (ND), and P. parasitica (IC50 3 ug/ml). It also inhibited B. subtilis (IC50 38 ug/ml) but not E.coli, A.tumefaciens.

Evidence 9 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 38 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

ci (IC50 5 ug/ml), Pythium spp. (ND), and P. parasitica (IC50 3 ug/ml). It also inhibited B. subtilis (IC50 38 ug/ml) but not E.coli, A.tumefaciens.

Evidence 10 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 16 µg/mL

Target

Target Organism B. cinerea

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against B. cinerea (IC50 16 ug/ml), C. langenarium (IC50 4 ug/ml), S. sclerotiorum (IC50 11 ug/ml), F. oxysporum (IC50 10 ug

Evidence 11 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 4 µg/mL

Target

Target Organism C. langenarium

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against B. cinerea (IC50 16 ug/ml), C. langenarium (IC50 4 ug/ml), S. sclerotiorum (IC50 11 ug/ml), F. oxysporum (IC50 10 ug/ml), S. cerevissiae (IC50 14 u

Evidence 12 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 11 µg/mL

Target

Target Organism S. sclerotiorum

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against B. cinerea (IC50 16 ug/ml), C. langenarium (IC50 4 ug/ml), S. sclerotiorum (IC50 11 ug/ml), F. oxysporum (IC50 10 ug/ml), S. cerevissiae (IC50 14 ug/ml), R. solani (IC50 26 ug/ml),

Evidence 13 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 10 µg/mL

Target

Target Organism F. oxysporum

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 14 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 14 µg/mL

Target

Target Organism S. cerevissiae

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 15 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 26 µg/mL

Target

Target Organism R. solani

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 16 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 5 µg/mL

Target

Target Organism P. capsici

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 17 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 3 µg/mL

Target

Target Organism P. parasitica

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

0 14 ug/ml), R. solani (IC50 26 ug/ml), P. capsici (IC50 5 ug/ml), Pythium spp. (ND), and P. parasitica (IC50 3 ug/ml). It also inhibited B. subtilis (IC50 38 ug/ml) but not E.coli, A.tumefaciens.

Evidence 18 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 38 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

ci (IC50 5 ug/ml), Pythium spp. (ND), and P. parasitica (IC50 3 ug/ml). It also inhibited B. subtilis (IC50 38 ug/ml) but not E.coli, A.tumefaciens.

Evidence 19 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 16 µg/mL

Target

Target Organism B. cinerea

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against B. cinerea (IC50 16 ug/ml), C. langenarium (IC50 4 ug/ml), S. sclerotiorum (IC50 11 ug/ml), F. oxysporum (IC50 10 ug

Evidence 20 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 4 µg/mL

Target

Target Organism C. langenarium

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against B. cinerea (IC50 16 ug/ml), C. langenarium (IC50 4 ug/ml), S. sclerotiorum (IC50 11 ug/ml), F. oxysporum (IC50 10 ug/ml), S. cerevissiae (IC50 14 u

Evidence 21 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 11 µg/mL

Target

Target Organism S. sclerotiorum

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against B. cinerea (IC50 16 ug/ml), C. langenarium (IC50 4 ug/ml), S. sclerotiorum (IC50 11 ug/ml), F. oxysporum (IC50 10 ug/ml), S. cerevissiae (IC50 14 ug/ml), R. solani (IC50 26 ug/ml),

Evidence 22 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 10 µg/mL

Target

Target Organism F. oxysporum

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 23 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 14 µg/mL

Target

Target Organism S. cerevissiae

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 24 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 26 µg/mL

Target

Target Organism R. solani

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 25 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 5 µg/mL

Target

Target Organism P. capsici

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 26 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 3 µg/mL

Target

Target Organism P. parasitica

Source & Reference

Database Source DRAMP

Other

Evidence Text

0 14 ug/ml), R. solani (IC50 26 ug/ml), P. capsici (IC50 5 ug/ml), Pythium spp. (ND), and P. parasitica (IC50 3 ug/ml). It also inhibited B. subtilis (IC50 38 ug/ml) but not E.coli, A.tumefaciens.

Evidence 27 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 38 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source DRAMP

Other

Evidence Text

ci (IC50 5 ug/ml), Pythium spp. (ND), and P. parasitica (IC50 3 ug/ml). It also inhibited B. subtilis (IC50 38 ug/ml) but not E.coli, A.tumefaciens.