TPDB

3D PDB MODEL

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TPDB ID TPDB04614

Activity

Antibacterial Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 40-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.

Sequence

GFGCNGPWSEDDIQCHNHCKSIKGYKGGYCARGGFVCKCY

FASTA

>TPDB04614|Antibacterial;Toxicity|length=40
GFGCNGPWSEDDIQCHNHCKSIKGYKGGYCARGGFVCKCY

Formula C189H275N55O55S6

Absent Amino Acids LMT

Common Amino Acids G

Mass 4389.96

PI 8.02

Basic Residues 7

Acidic Residues 3

Hydrophobic Residues 10

Net Charge +2

Boman Index 4.29

Hydrophobicity -0.577

Aliphatic Index 29.25

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 10345

Absorbance 280nm 235.65

Polar Residues 14

number

1

A

1

R

2

N

2

D

6

C

1

E

1

Q

8

G

2

H

2

I

0

L

4

K

0

M

2

F

1

P

2

S

0

T

1

W

3

Y

1

V

Amino Acid Distribution

A: 1 R: 1 N: 2 D: 2 C: 6 E: 1 Q: 1 G: 8 H: 2 I: 2 L: 0 K: 4 M: 0 F: 2 P: 1 S: 2 T: 0 W: 1 Y: 3 V: 1

Length

40

Formula

C189H275N55O55S6

Mass

4389.96

PI

8.02

Net Charge

+2

Boman Index

4.29

Hydrophobicity

-0.577

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.46-0.91 µM

Target

Target Organism Staphylococcus aureus ATCC43300 MRSA or TCC25923

Source & Reference

Database Source NA

Other

Evidence Text

Active against S. aureus ATCC43300 MRSA or TCC25923 (MIC 0.46-0.91 uM) and S. hyicus NCTC10350 or 437–2 (MIC 0.91 uM).

Evidence 2 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Cytotoxic

Toxicity Raw

- | NA | target cell: Human primary macrophages

Target

Target Cell Human primary macrophages

Source & Reference

Database Source NA

Source Database DBAASP

Reference

A novel derivative of the fungal antimicrobial peptide plectasin is active against Mycobacterium tuberculosis. | Tuberculosis (Edinb) | 2018

Evidence 3 Activity

Activity

Activity Endpoint 1.9% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 128 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

1.9% Hemolysis | 128 | µg/mL | target cell: Mouse erythrocytes

Target

Target Cell Mouse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

A new high-yielding antimicrobial peptide NZX and its antibacterial activity against Staphylococcus hyicus in vitro/vivo. | Appl Microbiol Biotechnol | 2020

Evidence 4 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Cytotoxic

Toxicity Raw

NA | target cell: Human keratinocytes HaCat

Target

Target Cell Human keratinocytes HaCat

Source & Reference

Database Source NA

Source Database DBAASP

Reference

A new high-yielding antimicrobial peptide NZX and its antibacterial activity against Staphylococcus hyicus in vitro/vivo. | Appl Microbiol Biotechnol | 2020