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Peptide record

TPDB04584

Antibacterial Toxicity standard
38 amino acids
Basic Information
3D PDB MODEL
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TPDB04584
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 38-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
GFGCPFNKNECHAHCLSIGRKFGFCAGPLRATCTCGKQ
Physicochemical Analysis
C174H268N54O47S6
DMWYV
CG
4060.74
8.60
7
1
10
+4
3.42
-0.137
38.68
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
375
9.23
12
Residue Composition
number
3
A
2
R
2
N
0
D
6
C
1
E
1
Q
6
G
2
H
1
I
2
L
3
K
0
M
4
F
2
P
1
S
2
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 2 N: 2 D: 0 C: 6 E: 1 Q: 1 G: 6 H: 2 I: 1 L: 2 K: 3 M: 0 F: 4 P: 2 S: 1 T: 2 W: 0 Y: 0 V: 0
Chemical Descriptors
38
C174H268N54O47S6
4060.74
8.60
+4
3.42
-0.137
Evidence Records 3 records
Evidence 1 Activity

Activity

<5% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
<5% Hemolysis | 25 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Single-point mutation-mediated local amphipathic adjustment dramatically enhances antibacterial activity of a fungal defensin. | FASEB J | 2016
Evidence 2 Activity

Activity

10% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
10% Hemolysis | 50 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Single-point mutation-mediated local amphipathic adjustment dramatically enhances antibacterial activity of a fungal defensin. | FASEB J | 2016
Evidence 3 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Single-point mutation-mediated local amphipathic adjustment dramatically enhances antibacterial activity of a fungal defensin. | FASEB J | 2016