Back to search

Peptide record

TPDB04574

Antibacterial Anticancer Antifungal Antiviral Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB04574
Antibacterial Anticancer Antifungal Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept AI4AVP dbAMP 3.0 DRAVP 2.0
standard
No
A 37-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
GFGCPFNQGQCHKHCQSIRRRGGYCDGFLKTRCVCYR
Physicochemical Analysis
C181H278N62O48S6
AEMW
CG
4282.95
9.25
9
1
8
+6
4.61
-0.714
28.92
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
3355
78.33
14
Residue Composition
number
0
A
5
R
1
N
1
D
6
C
0
E
3
Q
6
G
2
H
1
I
1
L
2
K
0
M
3
F
1
P
1
S
1
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 5 N: 1 D: 1 C: 6 E: 0 Q: 3 G: 6 H: 2 I: 1 L: 1 K: 2 M: 0 F: 3 P: 1 S: 1 T: 1 W: 0 Y: 2 V: 1
Chemical Descriptors
37
C181H278N62O48S6
4282.95
9.25
+6
4.61
-0.714
Evidence Records 18 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.08-0.63 µM

Target

Staphylococcus aureus AB94004 or ATCC25923 or MRSA

Source & Reference

NA

Other

n defensin that inhibits virus. In addition, this peptide can inhibit the growth of Gram+ S. aureus AB94004 or ATCC25923 or MRSA (MIC 0.08-0.63 uM), B. subtilis AB91021 (MIC 10 uM), B. thuringiensis AB92037 (MIC 20 uM), M. luteus AB93113
Evidence 2 Activity

Activity

MIC
Antibacterial
10 µM

Target

B. subtilis AB91021

Source & Reference

NA

Other

an inhibit the growth of Gram+ S. aureus AB94004 or ATCC25923 or MRSA (MIC 0.08-0.63 uM), B. subtilis AB91021 (MIC 10 uM), B. thuringiensis AB92037 (MIC 20 uM), M. luteus AB93113 (MIC 0.16 uM), and S. epidermidi
Evidence 3 Activity

Activity

MIC
Antibacterial
20 µM

Target

B. thuringiensis AB92037

Source & Reference

NA

Other

aureus AB94004 or ATCC25923 or MRSA (MIC 0.08-0.63 uM), B. subtilis AB91021 (MIC 10 uM), B. thuringiensis AB92037 (MIC 20 uM), M. luteus AB93113 (MIC 0.16 uM), and S. epidermidis PRSE P1389 (MIC 0.31 uM). Similar to
Evidence 4 Activity

Activity

MIC
Antibacterial
0.16 µM

Target

M. luteus AB93113

Source & Reference

NA

Other

MIC 0.08-0.63 uM), B. subtilis AB91021 (MIC 10 uM), B. thuringiensis AB92037 (MIC 20 uM), M. luteus AB93113 (MIC 0.16 uM), and S. epidermidis PRSE P1389 (MIC 0.31 uM). Similar to neurotoxin, it could also effect
Evidence 5 Activity

Activity

MIC
Antibacterial
0.31 µM

Target

Staphylococcus epidermidis PRSE P1389

Source & Reference

NA

Other

1 (MIC 10 uM), B. thuringiensis AB92037 (MIC 20 uM), M. luteus AB93113 (MIC 0.16 uM), and S. epidermidis PRSE P1389 (MIC 0.31 uM). Similar to neurotoxin, it could also effectively inhibit Kv1.1, Kv1.2, and Kv1.3 channel
Evidence 6 Activity

Activity

MIC
Antifungal
0.08-0.63 µM

Target

Staphylococcus aureus AB94004 or ATCC25923 or MRSA

Source & Reference

Antifungipept

Other

n defensin that inhibits virus. In addition, this peptide can inhibit the growth of Gram+ S. aureus AB94004 or ATCC25923 or MRSA (MIC 0.08-0.63 uM), B. subtilis AB91021 (MIC 10 uM), B. thuringiensis AB92037 (MIC 20 uM), M. luteus AB93113
Evidence 7 Activity

Activity

MIC
Antifungal
10 µM

Target

B. subtilis AB91021

Source & Reference

Antifungipept

Other

an inhibit the growth of Gram+ S. aureus AB94004 or ATCC25923 or MRSA (MIC 0.08-0.63 uM), B. subtilis AB91021 (MIC 10 uM), B. thuringiensis AB92037 (MIC 20 uM), M. luteus AB93113 (MIC 0.16 uM), and S. epidermidi
Evidence 8 Activity

Activity

MIC
Antifungal
20 µM

Target

B. thuringiensis AB92037

Source & Reference

Antifungipept

Other

aureus AB94004 or ATCC25923 or MRSA (MIC 0.08-0.63 uM), B. subtilis AB91021 (MIC 10 uM), B. thuringiensis AB92037 (MIC 20 uM), M. luteus AB93113 (MIC 0.16 uM), and S. epidermidis PRSE P1389 (MIC 0.31 uM). Similar to
Evidence 9 Activity

Activity

MIC
Antifungal
0.16 µM

Target

M. luteus AB93113

Source & Reference

Antifungipept

Other

MIC 0.08-0.63 uM), B. subtilis AB91021 (MIC 10 uM), B. thuringiensis AB92037 (MIC 20 uM), M. luteus AB93113 (MIC 0.16 uM), and S. epidermidis PRSE P1389 (MIC 0.31 uM). Similar to neurotoxin, it could also effect
Evidence 10 Activity

Activity

MIC
Antifungal
0.31 µM

Target

Staphylococcus epidermidis PRSE P1389

Source & Reference

Antifungipept

Other

1 (MIC 10 uM), B. thuringiensis AB92037 (MIC 20 uM), M. luteus AB93113 (MIC 0.16 uM), and S. epidermidis PRSE P1389 (MIC 0.31 uM). Similar to neurotoxin, it could also effectively inhibit Kv1.1, Kv1.2, and Kv1.3 channel
Evidence 11 Activity

Activity

MIC
Antiviral
0.08-0.63 µM

Target

Staphylococcus aureus AB94004 or ATCC25923 or MRSA

Source & Reference

dbAMP 3.0 DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
n defensin that inhibits virus. In addition, this peptide can inhibit the growth of Gram+ S. aureus AB94004 or ATCC25923 or MRSA (MIC 0.08-0.63 uM), B. subtilis AB91021 (MIC 10 uM), B. thuringiensis AB92037 (MIC 20 uM), M. luteus AB93113
Evidence 12 Activity

Activity

MIC
Antiviral
10 µM

Target

B. subtilis AB91021

Source & Reference

dbAMP 3.0 DRAVP 2.0

Other

an inhibit the growth of Gram+ S. aureus AB94004 or ATCC25923 or MRSA (MIC 0.08-0.63 uM), B. subtilis AB91021 (MIC 10 uM), B. thuringiensis AB92037 (MIC 20 uM), M. luteus AB93113 (MIC 0.16 uM), and S. epidermidi
Evidence 13 Activity

Activity

MIC
Antiviral
20 µM

Target

B. thuringiensis AB92037

Source & Reference

dbAMP 3.0 DRAVP 2.0

Other

aureus AB94004 or ATCC25923 or MRSA (MIC 0.08-0.63 uM), B. subtilis AB91021 (MIC 10 uM), B. thuringiensis AB92037 (MIC 20 uM), M. luteus AB93113 (MIC 0.16 uM), and S. epidermidis PRSE P1389 (MIC 0.31 uM). Similar to
Evidence 14 Activity

Activity

MIC
Antiviral
0.16 µM

Target

M. luteus AB93113

Source & Reference

dbAMP 3.0 DRAVP 2.0

Other

MIC 0.08-0.63 uM), B. subtilis AB91021 (MIC 10 uM), B. thuringiensis AB92037 (MIC 20 uM), M. luteus AB93113 (MIC 0.16 uM), and S. epidermidis PRSE P1389 (MIC 0.31 uM). Similar to neurotoxin, it could also effect
Evidence 15 Activity

Activity

MIC
Antiviral
0.31 µM

Target

Staphylococcus epidermidis PRSE P1389

Source & Reference

dbAMP 3.0 DRAVP 2.0

Other

1 (MIC 10 uM), B. thuringiensis AB92037 (MIC 20 uM), M. luteus AB93113 (MIC 0.16 uM), and S. epidermidis PRSE P1389 (MIC 0.31 uM). Similar to neurotoxin, it could also effectively inhibit Kv1.1, Kv1.2, and Kv1.3 channel
Evidence 16 Activity

Activity

50% Hemolysis
Toxicity
66.85 µM
Hemolytic Cytotoxic
50% Hemolysis | 66.85 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A Scorpion Defensin BmKDfsin4 Inhibits Hepatitis B Virus Replication in Vitro. | Toxins (Basel) | 2016
Evidence 17 Activity

Activity

50% Cytotoxicity
Toxicity
103.77 µM
Cytotoxic
50% Cytotoxicity | 103.77 | µM | target cell: Human hepatocyte cells HL-7702 (L02)

Target

Human hepatocyte cells HL-7702 (L02)

Source & Reference

NA
DBAASP
A Scorpion Defensin BmKDfsin4 Inhibits Hepatitis B Virus Replication in Vitro. | Toxins (Basel) | 2016
Evidence 18 Activity

Activity

% Hemolysis
Toxicity
50 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.27128943]Human erythrocytes: 50% hemolysis concentration was 66.85 µM. | Cytotoxicity: [Ref.27128943]HepG2.2.15 cells: CC50= 167.82 µM ##HepG2 cells: CC50= 154.24 µM ##L-02 cells: CC50= 103.77 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
Toxins (Basel). 2016 Apr 27 8(5):124.