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Peptide record

TPDB04533

Antibacterial Toxicity standard
34 amino acids
Basic Information
3D PDB MODEL
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TPDB04533
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 34-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
SVPTSVYTLGIKILWSAYKHRKTIEKSFNKGFYH
Physicochemical Analysis
C189H288N48O48
DCQM
K
4000.66
10.38
8
1
14
+5
2.52
-0.382
77.35
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
9970
249.21
11
Residue Composition
number
1
A
1
R
1
N
0
D
0
C
1
E
0
Q
2
G
2
H
3
I
2
L
5
K
0
M
2
F
1
P
4
S
3
T
1
W
3
Y
2
V
Amino Acid Distribution
A: 1 R: 1 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 2 H: 2 I: 3 L: 2 K: 5 M: 0 F: 2 P: 1 S: 4 T: 3 W: 1 Y: 3 V: 2
Chemical Descriptors
34
C189H288N48O48
4000.66
10.38
+5
2.52
-0.382
Evidence Records 5 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
0% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Plantaricin NC8 alpha beta Exerts Potent Antimicrobial Activity Against Staphylococcus Spp. And Enhances the Effects of Antibiotics. | Sci Rep | 2020
Evidence 2 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Plantaricin NC8 alpha beta Exerts Potent Antimicrobial Activity Against Staphylococcus Spp. And Enhances the Effects of Antibiotics. | Sci Rep | 2020
Evidence 3 Activity

Activity

<5% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
<5% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Development of novel broad-spectrum antimicrobial lipopeptides derived from plantaricin NC8 β. | Sci Rep | 2023
Evidence 4 Activity

Activity

9.8% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
9.8% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Plantaricin NC8 alpha beta Exerts Potent Antimicrobial Activity Against Staphylococcus Spp. And Enhances the Effects of Antibiotics. | Sci Rep | 2020
Evidence 5 Activity

Activity

Toxicity
Cytotoxic
NA | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Plantaricin NC8 alpha beta Exerts Potent Antimicrobial Activity Against Staphylococcus Spp. And Enhances the Effects of Antibiotics. | Sci Rep | 2020