TPDB

3D PDB MODEL

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TPDB ID TPDB04525

Activity

Antibacterial Antifungal

Activity_category_statistics

Anti-infective peptides

Database_Source

AntiBP3 Peptipedia Antifungipept

Sequence_Type

standard

Has_Modification No

Description A 33-aa standard natural multi-activity (Antibacterial and Antifungal) peptide sequence curated from AntiBP3, Peptipedia, and Antifungipept, with an available 3D structural model.

Sequence

WGWKEVVQNGQTIFSAGQKLGNMVGKIVPLPFG

FASTA

>TPDB04525|Antibacterial;Antifungal|length=33
WGWKEVVQNGQTIFSAGQKLGNMVGKIVPLPFG

Formula C167H257N43O43S1

Absent Amino Acids RDCHY

Common Amino Acids G

Mass 3587.20

PI 10.32

Basic Residues 3

Acidic Residues 1

Hydrophobic Residues 14

Net Charge +2

Boman Index 0.98

Hydrophobicity 0.033

Aliphatic Index 85.45

Half Life

Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 11000

Absorbance 280nm 306.65

Polar Residues 7

number

1

A

0

R

2

N

0

D

0

C

1

E

3

Q

6

G

0

H

2

I

2

L

3

K

1

M

2

F

2

P

1

S

1

T

2

W

0

Y

4

V

Amino Acid Distribution

A: 1 R: 0 N: 2 D: 0 C: 0 E: 1 Q: 3 G: 6 H: 0 I: 2 L: 2 K: 3 M: 1 F: 2 P: 2 S: 1 T: 1 W: 2 Y: 0 V: 4

Length

33

Formula

C167H257N43O43S1

Mass

3587.20

PI

10.32

Net Charge

+2

Boman Index

0.98

Hydrophobicity

0.033

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism C. divergens LV13

Source & Reference

Database Source NA

Other

Evidence Text

Active against two indicator strains C. divergens LV13 (MIC 4 uM) and C. maltaromaticum A9b- (MIC 8 uM) using spot-on-lawn assays. MIC values are 15.6 and

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µM

Target

Target Organism C. maltaromaticum A9b-

Source & Reference

Database Source NA

Other

Evidence Text

Active against two indicator strains C. divergens LV13 (MIC 4 uM) and C. maltaromaticum A9b- (MIC 8 uM) using spot-on-lawn assays. MIC values are 15.6 and 31.25 uM based on the microdilution me

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µM

Target

Target Organism C. divergens LV13

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Active against two indicator strains C. divergens LV13 (MIC 4 uM) and C. maltaromaticum A9b- (MIC 8 uM) using spot-on-lawn assays. MIC values are 15.6 and

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8 µM

Target

Target Organism C. maltaromaticum A9b-

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Active against two indicator strains C. divergens LV13 (MIC 4 uM) and C. maltaromaticum A9b- (MIC 8 uM) using spot-on-lawn assays. MIC values are 15.6 and 31.25 uM based on the microdilution me