TPDB

3D PDB MODEL

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TPDB ID TPDB04444

Activity

Antibacterial Antifungal

Activity_category_statistics

Anti-infective peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia Antifungipept

Sequence_Type

standard

Has_Modification No

Description A 26-aa standard natural multi-activity (Antibacterial and Antifungal) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

GDCGGTCTWTKDCSICPSWSCWSWSC

FASTA

>TPDB04444|Antibacterial;Antifungal|length=26
GDCGGTCTWTKDCSICPSWSCWSWSC

Formula C120H167N31O39S6

Absent Amino Acids ARNEQHLMFYV

Common Amino Acids C

Mass 2860.19

PI 3.88

Basic Residues 1

Acidic Residues 2

Hydrophobic Residues 5

Net Charge -1

Boman Index -4.15

Hydrophobicity -0.150

Aliphatic Index 15.00

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 22375

Absorbance 280nm 782.29

Polar Residues 14

number

0

A

0

R

0

N

2

D

6

C

0

E

0

Q

3

G

0

H

1

I

0

L

1

K

0

M

0

F

1

P

5

S

3

T

4

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 2 C: 6 E: 0 Q: 0 G: 3 H: 0 I: 1 L: 0 K: 1 M: 0 F: 0 P: 1 S: 5 T: 3 W: 4 Y: 0 V: 0

Length

26

Formula

C120H167N31O39S6

Mass

2860.19

PI

3.88

Net Charge

-1

Boman Index

-4.15

Hydrophobicity

-0.150

Evidence 1 Activity

Activity

Detail Source Activity Antibacterial

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

zone inhibition: The recombinant form is active against B. subtilis (TMB016, TMB299, 416 TMB588), Streptococcus G 3643”10”, all tested S. aureus strains (S. aureus SG511, S. aureus 417 1000/93 and S. aureus 635/93), L. lactis NCTC497 and M. luteus. Not active against Gram- bacteria and C.albicans. Updated 11/2022 GW

Evidence 2 Activity

Activity

Detail Source Activity Antifungal

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

zone inhibition: The recombinant form is active against B. subtilis (TMB016, TMB299, 416 TMB588), Streptococcus G 3643”10”, all tested S. aureus strains (S. aureus SG511, S. aureus 417 1000/93 and S. aureus 635/93), L. lactis NCTC497 and M. luteus. Not active against Gram- bacteria and C.albicans. Updated 11/2022 GW