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Peptide record

TPDB04426

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB04426
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 24-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FMGSALRIAAKVLPAALCQIFKKC
Physicochemical Analysis
C118H199N31O27S3
NDEHTWY
A
2580.25
10.32
4
0
14
+4
-1.10
0.983
114.17
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
125
4.84
4
Residue Composition
number
5
A
1
R
0
N
0
D
2
C
0
E
1
Q
1
G
0
H
2
I
3
L
3
K
1
M
2
F
1
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 5 R: 1 N: 0 D: 0 C: 2 E: 0 Q: 1 G: 1 H: 0 I: 2 L: 3 K: 3 M: 1 F: 2 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
24
C118H199N31O27S3
2580.25
10.32
+4
-1.10
0.983
Evidence Records 20 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6.25 µg/mL

Target

Staphylococcus aureus ATCC2592

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against Gram+ S. aureus ATCC2592 (MIC 6.25 ug/ml), B. subtilis ATCC6633 (MIC 6.25 ug/ml), Gram- P. fluorescens ATCC13525 (MIC 100 ug/ml), a
Evidence 2 Activity

Activity

MIC
Antibacterial
6.25 µg/mL

Target

B. subtilis ATCC6633

Source & Reference

dbAMP DRAMP

Other

Active against Gram+ S. aureus ATCC2592 (MIC 6.25 ug/ml), B. subtilis ATCC6633 (MIC 6.25 ug/ml), Gram- P. fluorescens ATCC13525 (MIC 100 ug/ml), and fungus C. albicans ATCC2002 (MIC 50
Evidence 3 Activity

Activity

MIC
Antibacterial
100 µg/mL

Target

Pseudomonas fluorescens ATCC13525

Source & Reference

dbAMP DRAMP

Other

t Gram+ S. aureus ATCC2592 (MIC 6.25 ug/ml), B. subtilis ATCC6633 (MIC 6.25 ug/ml), Gram- P. fluorescens ATCC13525 (MIC 100 ug/ml), and fungus C. albicans ATCC2002 (MIC 50 ug/ml). Hemolysis LD50 >200 ug/ml. Updated 5/202
Evidence 4 Activity

Activity

MIC
Antibacterial
50 µg/mL

Target

Candida albicans ATCC2002

Source & Reference

dbAMP DRAMP

Other

lis ATCC6633 (MIC 6.25 ug/ml), Gram- P. fluorescens ATCC13525 (MIC 100 ug/ml), and fungus C. albicans ATCC2002 (MIC 50 ug/ml). Hemolysis LD50 >200 ug/ml. Updated 5/2020 7/2021
Evidence 5 Activity

Activity

MIC
Antifungal
6.25 µg/mL

Target

Staphylococcus aureus ATCC2592

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against Gram+ S. aureus ATCC2592 (MIC 6.25 ug/ml), B. subtilis ATCC6633 (MIC 6.25 ug/ml), Gram- P. fluorescens ATCC13525 (MIC 100 ug/ml), a
Evidence 6 Activity

Activity

MIC
Antifungal
6.25 µg/mL

Target

B. subtilis ATCC6633

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against Gram+ S. aureus ATCC2592 (MIC 6.25 ug/ml), B. subtilis ATCC6633 (MIC 6.25 ug/ml), Gram- P. fluorescens ATCC13525 (MIC 100 ug/ml), and fungus C. albicans ATCC2002 (MIC 50
Evidence 7 Activity

Activity

MIC
Antifungal
100 µg/mL

Target

Pseudomonas fluorescens ATCC13525

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

t Gram+ S. aureus ATCC2592 (MIC 6.25 ug/ml), B. subtilis ATCC6633 (MIC 6.25 ug/ml), Gram- P. fluorescens ATCC13525 (MIC 100 ug/ml), and fungus C. albicans ATCC2002 (MIC 50 ug/ml). Hemolysis LD50 >200 ug/ml. Updated 5/202
Evidence 8 Activity

Activity

MIC
Antifungal
50 µg/mL

Target

Candida albicans ATCC2002

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

lis ATCC6633 (MIC 6.25 ug/ml), Gram- P. fluorescens ATCC13525 (MIC 100 ug/ml), and fungus C. albicans ATCC2002 (MIC 50 ug/ml). Hemolysis LD50 >200 ug/ml. Updated 5/2020 7/2021
Evidence 9 Activity

Activity

MIC
Antiparasitic
6.25 µg/mL

Target

Staphylococcus aureus ATCC2592

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against Gram+ S. aureus ATCC2592 (MIC 6.25 ug/ml), B. subtilis ATCC6633 (MIC 6.25 ug/ml), Gram- P. fluorescens ATCC13525 (MIC 100 ug/ml), a
Evidence 10 Activity

Activity

MIC
Antiparasitic
6.25 µg/mL

Target

B. subtilis ATCC6633

Source & Reference

DRAMP

Other

Active against Gram+ S. aureus ATCC2592 (MIC 6.25 ug/ml), B. subtilis ATCC6633 (MIC 6.25 ug/ml), Gram- P. fluorescens ATCC13525 (MIC 100 ug/ml), and fungus C. albicans ATCC2002 (MIC 50
Evidence 11 Activity

Activity

MIC
Antiparasitic
100 µg/mL

Target

Pseudomonas fluorescens ATCC13525

Source & Reference

DRAMP

Other

t Gram+ S. aureus ATCC2592 (MIC 6.25 ug/ml), B. subtilis ATCC6633 (MIC 6.25 ug/ml), Gram- P. fluorescens ATCC13525 (MIC 100 ug/ml), and fungus C. albicans ATCC2002 (MIC 50 ug/ml). Hemolysis LD50 >200 ug/ml. Updated 5/202
Evidence 12 Activity

Activity

MIC
Antiparasitic
50 µg/mL

Target

Candida albicans ATCC2002

Source & Reference

DRAMP

Other

lis ATCC6633 (MIC 6.25 ug/ml), Gram- P. fluorescens ATCC13525 (MIC 100 ug/ml), and fungus C. albicans ATCC2002 (MIC 50 ug/ml). Hemolysis LD50 >200 ug/ml. Updated 5/2020 7/2021
Evidence 13 Activity

Activity

MIC
Antiviral
6.25 µg/mL

Target

Staphylococcus aureus ATCC2592

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Active against Gram+ S. aureus ATCC2592 (MIC 6.25 ug/ml), B. subtilis ATCC6633 (MIC 6.25 ug/ml), Gram- P. fluorescens ATCC13525 (MIC 100 ug/ml), a
Evidence 14 Activity

Activity

MIC
Antiviral
6.25 µg/mL

Target

B. subtilis ATCC6633

Source & Reference

DRAMP

Other

Active against Gram+ S. aureus ATCC2592 (MIC 6.25 ug/ml), B. subtilis ATCC6633 (MIC 6.25 ug/ml), Gram- P. fluorescens ATCC13525 (MIC 100 ug/ml), and fungus C. albicans ATCC2002 (MIC 50
Evidence 15 Activity

Activity

MIC
Antiviral
100 µg/mL

Target

Pseudomonas fluorescens ATCC13525

Source & Reference

DRAMP

Other

t Gram+ S. aureus ATCC2592 (MIC 6.25 ug/ml), B. subtilis ATCC6633 (MIC 6.25 ug/ml), Gram- P. fluorescens ATCC13525 (MIC 100 ug/ml), and fungus C. albicans ATCC2002 (MIC 50 ug/ml). Hemolysis LD50 >200 ug/ml. Updated 5/202
Evidence 16 Activity

Activity

MIC
Antiviral
50 µg/mL

Target

Candida albicans ATCC2002

Source & Reference

DRAMP

Other

lis ATCC6633 (MIC 6.25 ug/ml), Gram- P. fluorescens ATCC13525 (MIC 100 ug/ml), and fungus C. albicans ATCC2002 (MIC 50 ug/ml). Hemolysis LD50 >200 ug/ml. Updated 5/2020 7/2021
Evidence 17 Activity

Activity

LC50
Hemolysis
200 µg/mL
[Ref.19340924]LC50>200 µg/ml against rabbit red blood cells

Target

rabbit red blood cells

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Biochimie. 2009 Apr 91(4):540-547.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 18 Activity

Activity

50% Hemolysis
Toxicity
>200 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >200 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Isolation, characterization and molecular cloning of new antimicrobial peptides belonging to the brevinin-1 and temporin families from the skin of Hylarana latouchii (Anura: Ranidae). | Biochimie | 2009
Evidence 19 Activity

Activity

LC50
Toxicity
200 µg/mL
Hemolytic
Hemolytic_activity: [Ref.19340924]LC50>200 µg/ml against rabbit red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochimie. 2009 Apr 91(4):540-547.
Evidence 20 Hemolysis

Activity

200 µg/mL
LC50
[Ref.19340924]LC50>200 µg/ml against rabbit red blood cells
Hemolysis

Target

rabbit red blood cells

Source & Reference

APD_complete HemoPI PD_Hemolysis
Biochimie. 2009 Apr 91(4):540-547.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.