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Peptide record

TPDB04424

Antibacterial Anticancer Antifungal Antiparasitic standard

24 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB04424

Activity

Antibacterial Anticancer Antifungal Antiparasitic

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia Antifungipept

Sequence_Type

standard

Has_Modification No

Description A 24-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

GNGVVLTLTHECNLATWTKKLKCC

FASTA

>TPDB04424|Antibacterial;Anticancer;Antifungal;Antiparasitic|length=24
GNGVVLTLTHECNLATWTKKLKCC

Formula C114H190N32O33S3

Absent Amino Acids RDQIMFPSY

Common Amino Acids LT

Mass 2633.14

PI 8.57

Basic Residues 4

Acidic Residues 1

Hydrophobic Residues 8

Net Charge +2

Boman Index 2.53

Hydrophobicity 0.125

Aliphatic Index 93.33

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 5625

Absorbance 280nm 213.62

Polar Residues 9

number

Amino Acid Distribution

A: 1 R: 0 N: 2 D: 0 C: 3 E: 1 Q: 0 G: 2 H: 1 I: 0 L: 4 K: 3 M: 0 F: 0 P: 0 S: 0 T: 4 W: 1 Y: 0 V: 2

Length

Formula

C114H190N32O33S3

Mass

2633.14

8.57

Net Charge

Boman Index

2.53

Hydrophobicity

0.125

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism M. luteus ATCC10240

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against M. luteus ATCC10240 (MIC 4 uM), M. luteus GAB13 (MIC 16 uM), S. equisimilis ATCC12388 (64 uM), Corynebacterium spp GH17

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 16 µM

Target

Target Organism M. luteus GAB13

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against M. luteus ATCC10240 (MIC 4 uM), M. luteus GAB13 (MIC 16 uM), S. equisimilis ATCC12388 (64 uM), Corynebacterium spp GH17 (MIC 8 uM), S. pyogenes ATCC1

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 32 µM

Target

Target Organism Streptococcus pyogenes ATCC12384

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

quisimilis ATCC12388 (64 uM), Corynebacterium spp GH17 (MIC 8 uM), S. pyogenes ATCC12344, S. pyogenes ATCC12384 (MIC 32 uM).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µM

Target

Target Organism M. luteus ATCC10240

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against M. luteus ATCC10240 (MIC 4 uM), M. luteus GAB13 (MIC 16 uM), S. equisimilis ATCC12388 (64 uM), Corynebacterium spp GH17

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 16 µM

Target

Target Organism M. luteus GAB13

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Active against M. luteus ATCC10240 (MIC 4 uM), M. luteus GAB13 (MIC 16 uM), S. equisimilis ATCC12388 (64 uM), Corynebacterium spp GH17 (MIC 8 uM), S. pyogenes ATCC1

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 32 µM

Target

Target Organism Streptococcus pyogenes ATCC12384

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

quisimilis ATCC12388 (64 uM), Corynebacterium spp GH17 (MIC 8 uM), S. pyogenes ATCC12344, S. pyogenes ATCC12384 (MIC 32 uM).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 4 µM

Target

Target Organism M. luteus ATCC10240

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against M. luteus ATCC10240 (MIC 4 uM), M. luteus GAB13 (MIC 16 uM), S. equisimilis ATCC12388 (64 uM), Corynebacterium spp GH17

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 16 µM

Target

Target Organism M. luteus GAB13

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against M. luteus ATCC10240 (MIC 4 uM), M. luteus GAB13 (MIC 16 uM), S. equisimilis ATCC12388 (64 uM), Corynebacterium spp GH17 (MIC 8 uM), S. pyogenes ATCC1

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 32 µM

Target

Target Organism Streptococcus pyogenes ATCC12384

Source & Reference

Database Source DRAMP

Other

Evidence Text

quisimilis ATCC12388 (64 uM), Corynebacterium spp GH17 (MIC 8 uM), S. pyogenes ATCC12344, S. pyogenes ATCC12384 (MIC 32 uM).