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Peptide record

TPDB04398

Maculatin 1.2 Antibacterial Anticancer Antifungal Antiparasitic Antiviral standard

23 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB04398

Peptide_Name

Maculatin 1.2

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab Antifungipept

Sequence_Type

standard

Has_Modification No

Description A 23-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

GLFVGLAKVAAHNNPAIAEHFQA

FASTA

>TPDB04398|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral|length=23
GLFVGLAKVAAHNNPAIAEHFQA

Formula C109H167N31O29

Absent Amino Acids RDCMSTWY

Common Amino Acids A

Mass 2375.72

PI 7.97

Basic Residues 3

Acidic Residues 1

Hydrophobic Residues 13

Net Charge +0

Boman Index 2.25

Hydrophobicity 0.443

Aliphatic Index 102.17

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 3

number

Amino Acid Distribution

A: 6 R: 0 N: 2 D: 0 C: 0 E: 1 Q: 1 G: 2 H: 2 I: 1 L: 2 K: 1 M: 0 F: 2 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 2

Length

Formula

C109H167N31O29

Mass

2375.72

7.97

Net Charge

Boman Index

2.25

Hydrophobicity

0.443

C_terminal_Modification

Free

Chirality

Linear_or_Cyclic

Not Available

N_terminal_Modification

Free

Nature

Antibacterial

Origin

Litoria genimaculate, Litoria eucnemis, Australia

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µg/mL

Target

Target Organism B.cereus

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Activity against B.cereus (MIC >100 ug/ml), L.lactis (MIC >100 ug/ml), L.innocua (MIC >100 ug/ml), M.luteus (MIC >100 ug/ml), P.mult

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µg/mL

Target

Target Organism L.lactis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Activity against B.cereus (MIC >100 ug/ml), L.lactis (MIC >100 ug/ml), L.innocua (MIC >100 ug/ml), M.luteus (MIC >100 ug/ml), P.multocida (MIC >100 ug/ml), S.

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µg/mL

Target

Target Organism L.innocua

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Activity against B.cereus (MIC >100 ug/ml), L.lactis (MIC >100 ug/ml), L.innocua (MIC >100 ug/ml), M.luteus (MIC >100 ug/ml), P.multocida (MIC >100 ug/ml), S. aureus (MIC 50 ug/ml), S. ub

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µg/mL

Target

Target Organism M.luteus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

against B.cereus (MIC >100 ug/ml), L.lactis (MIC >100 ug/ml), L.innocua (MIC >100 ug/ml), M.luteus (MIC >100 ug/ml), P.multocida (MIC >100 ug/ml), S. aureus (MIC 50 ug/ml), S. uberis (MIC 6 ug/ml), S.epide

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µg/mL

Target

Target Organism P.multocida

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

ug/ml), L.lactis (MIC >100 ug/ml), L.innocua (MIC >100 ug/ml), M.luteus (MIC >100 ug/ml), P.multocida (MIC >100 ug/ml), S. aureus (MIC 50 ug/ml), S. uberis (MIC 6 ug/ml), S.epidermidis (MIC >100 ug/ml), S.fae

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 50 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

ml), L.innocua (MIC >100 ug/ml), M.luteus (MIC >100 ug/ml), P.multocida (MIC >100 ug/ml), S. aureus (MIC 50 ug/ml), S. uberis (MIC 6 ug/ml), S.epidermidis (MIC >100 ug/ml), S.faecalis (MIC >100 ug/ml), E.

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6 µg/mL

Target

Target Organism S. uberis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

g/ml), M.luteus (MIC >100 ug/ml), P.multocida (MIC >100 ug/ml), S. aureus (MIC 50 ug/ml), S. uberis (MIC 6 ug/ml), S.epidermidis (MIC >100 ug/ml), S.faecalis (MIC >100 ug/ml), E.coli (MIC >100 ug/ml). Up

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µg/mL

Target

Target Organism S.epidermidis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

ug/ml), P.multocida (MIC >100 ug/ml), S. aureus (MIC 50 ug/ml), S. uberis (MIC 6 ug/ml), S.epidermidis (MIC >100 ug/ml), S.faecalis (MIC >100 ug/ml), E.coli (MIC >100 ug/ml). Updated 7/2021, Jan2023 12/2024.

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µg/mL

Target

Target Organism S.faecalis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

g/ml), S. aureus (MIC 50 ug/ml), S. uberis (MIC 6 ug/ml), S.epidermidis (MIC >100 ug/ml), S.faecalis (MIC >100 ug/ml), E.coli (MIC >100 ug/ml). Updated 7/2021, Jan2023 12/2024.

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µg/mL

Target

Target Organism E.coli

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

l), S. uberis (MIC 6 ug/ml), S.epidermidis (MIC >100 ug/ml), S.faecalis (MIC >100 ug/ml), E.coli (MIC >100 ug/ml). Updated 7/2021, Jan2023 12/2024.

Evidence 11 Activity

Activity

Activity Raw

Not Available

Detail Source Activity Anticancer

Target

Cancer Type Not Available

Cell Line Not Available

Tissue Affected Not Available

Assay & Model

Assay Not Available

Testing Time Not Available

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 1998

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µg/mL

Target

Target Organism B.cereus

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Activity against B.cereus (MIC >100 ug/ml), L.lactis (MIC >100 ug/ml), L.innocua (MIC >100 ug/ml), M.luteus (MIC >100 ug/ml), P.mult

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µg/mL

Target

Target Organism L.lactis

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Activity against B.cereus (MIC >100 ug/ml), L.lactis (MIC >100 ug/ml), L.innocua (MIC >100 ug/ml), M.luteus (MIC >100 ug/ml), P.multocida (MIC >100 ug/ml), S.

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µg/mL

Target

Target Organism L.innocua

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Activity against B.cereus (MIC >100 ug/ml), L.lactis (MIC >100 ug/ml), L.innocua (MIC >100 ug/ml), M.luteus (MIC >100 ug/ml), P.multocida (MIC >100 ug/ml), S. aureus (MIC 50 ug/ml), S. ub

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µg/mL

Target

Target Organism M.luteus

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µg/mL

Target

Target Organism P.multocida

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 50 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6 µg/mL

Target

Target Organism S. uberis

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µg/mL

Target

Target Organism S.epidermidis

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µg/mL

Target

Target Organism S.faecalis

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

g/ml), S. aureus (MIC 50 ug/ml), S. uberis (MIC 6 ug/ml), S.epidermidis (MIC >100 ug/ml), S.faecalis (MIC >100 ug/ml), E.coli (MIC >100 ug/ml). Updated 7/2021, Jan2023 12/2024.

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µg/mL

Target

Target Organism E.coli

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

l), S. uberis (MIC 6 ug/ml), S.epidermidis (MIC >100 ug/ml), S.faecalis (MIC >100 ug/ml), E.coli (MIC >100 ug/ml). Updated 7/2021, Jan2023 12/2024.

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >100 µg/mL

Target

Target Organism B.cereus

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Activity against B.cereus (MIC >100 ug/ml), L.lactis (MIC >100 ug/ml), L.innocua (MIC >100 ug/ml), M.luteus (MIC >100 ug/ml), P.mult

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >100 µg/mL

Target

Target Organism L.lactis

Source & Reference

Database Source DRAMP

Other

Evidence Text

Activity against B.cereus (MIC >100 ug/ml), L.lactis (MIC >100 ug/ml), L.innocua (MIC >100 ug/ml), M.luteus (MIC >100 ug/ml), P.multocida (MIC >100 ug/ml), S.

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >100 µg/mL

Target

Target Organism L.innocua

Source & Reference

Database Source DRAMP

Other

Evidence Text

Activity against B.cereus (MIC >100 ug/ml), L.lactis (MIC >100 ug/ml), L.innocua (MIC >100 ug/ml), M.luteus (MIC >100 ug/ml), P.multocida (MIC >100 ug/ml), S. aureus (MIC 50 ug/ml), S. ub

Evidence 25 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >100 µg/mL

Target

Target Organism M.luteus

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 26 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >100 µg/mL

Target

Target Organism P.multocida

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 27 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 50 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 28 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 6 µg/mL

Target

Target Organism S. uberis

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 29 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >100 µg/mL

Target

Target Organism S.epidermidis

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 30 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >100 µg/mL

Target

Target Organism S.faecalis

Source & Reference

Database Source DRAMP

Other

Evidence Text

g/ml), S. aureus (MIC 50 ug/ml), S. uberis (MIC 6 ug/ml), S.epidermidis (MIC >100 ug/ml), S.faecalis (MIC >100 ug/ml), E.coli (MIC >100 ug/ml). Updated 7/2021, Jan2023 12/2024.

Evidence 31 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >100 µg/mL

Target

Target Organism E.coli

Source & Reference

Database Source DRAMP

Other

Evidence Text

l), S. uberis (MIC 6 ug/ml), S.epidermidis (MIC >100 ug/ml), S.faecalis (MIC >100 ug/ml), E.coli (MIC >100 ug/ml). Updated 7/2021, Jan2023 12/2024.

Evidence 32 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement >100 µg/mL

Target

Target Organism B.cereus

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets.

Evidence Text

Activity against B.cereus (MIC >100 ug/ml), L.lactis (MIC >100 ug/ml), L.innocua (MIC >100 ug/ml), M.luteus (MIC >100 ug/ml), P.mult

Evidence 33 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement >100 µg/mL

Target

Target Organism L.lactis

Source & Reference

Database Source DRAMP

Other

Evidence Text

Activity against B.cereus (MIC >100 ug/ml), L.lactis (MIC >100 ug/ml), L.innocua (MIC >100 ug/ml), M.luteus (MIC >100 ug/ml), P.multocida (MIC >100 ug/ml), S.

Evidence 34 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement >100 µg/mL

Target

Target Organism L.innocua

Source & Reference

Database Source DRAMP

Other

Evidence Text

Activity against B.cereus (MIC >100 ug/ml), L.lactis (MIC >100 ug/ml), L.innocua (MIC >100 ug/ml), M.luteus (MIC >100 ug/ml), P.multocida (MIC >100 ug/ml), S. aureus (MIC 50 ug/ml), S. ub

Evidence 35 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement >100 µg/mL

Target

Target Organism M.luteus

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 36 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement >100 µg/mL

Target

Target Organism P.multocida

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 37 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 50 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 38 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 6 µg/mL

Target

Target Organism S. uberis

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 39 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement >100 µg/mL

Target

Target Organism S.epidermidis

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 40 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement >100 µg/mL

Target

Target Organism S.faecalis

Source & Reference

Database Source DRAMP

Other

Evidence Text

g/ml), S. aureus (MIC 50 ug/ml), S. uberis (MIC 6 ug/ml), S.epidermidis (MIC >100 ug/ml), S.faecalis (MIC >100 ug/ml), E.coli (MIC >100 ug/ml). Updated 7/2021, Jan2023 12/2024.

Evidence 41 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement >100 µg/mL

Target

Target Organism E.coli

Source & Reference

Database Source DRAMP

Other

Evidence Text

l), S. uberis (MIC 6 ug/ml), S.epidermidis (MIC >100 ug/ml), S.faecalis (MIC >100 ug/ml), E.coli (MIC >100 ug/ml). Updated 7/2021, Jan2023 12/2024.